Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Bruce A. Pappas"'
Publikováno v:
Brain Research. 1373:79-90
Previous work in our laboratory indicated that cholinergic denervation by intraventricular infusion of 192-IgG-saporin on postnatal day 7 (N192S) reduced the number of cells in the dentate gyrus expressing doublecortin, a marker for immature neurobla
Publikováno v:
Brain Research. 1252:172-182
Intraventricular injections of 192 IgG saporin in 7-day-old rat severely reduced hippocampal cholinergic innervation as reflected by both decreased acetylcholinesterase staining and immunoreactivity for the p75 neurotrophin receptor. It was determine
Publikováno v:
Journal of Pineal Research. 44:149-156
Melatonin attenuates the short-term consequences of brain ischemia in several animal models. However, there is scant information regarding its efficacy for improving the long-term outcome. To further address that issue, we subjected gerbils to 5-min
Autor:
M. De Butte, Bruce A. Pappas
Publikováno v:
Neurobiology of Aging. 28:306-313
This experiment determined if the loss of endogenous melatonin via pinealectomy affected rat CA1 and CA3 pyramidal neuron numbers over a 20-month span. Since pinealectomy eliminates many neurohormones, some rats received daily melatonin supplementati
Autor:
Julia C. Wallace, Frederick Kelcz, Bruce A. Pappas, Teresa Fortin, Greg O. Cron, Giles E. Santyr, W. Dale Stevens, Ruth C. Wilkins
Publikováno v:
Magnetic Resonance Imaging. 23:619-627
The arterial input function (AIF) is important for quantitative MR imaging perfusion experiments employing Gd contrast agents. This study compared the accuracy of T-2*-weighted magnitude and phase imaging for noninvasive measurement of the AIF in the
Autor:
K. Mantione, Teresa Fortin, Bruce A. Pappas, M.R. Emmerling, V. Prevot, J C de la Torre, M.D. Watson, George B. Stefano
Publikováno v:
Neurological Research. 25:635-641
Chronic brain hypoperfusion (CBH) using permanent occlusion of both common carotid arteries in an aging rat model, has been shown to mimic human mild cognitive impairment (MCI), an acknowledged high risk condition that often converts to Alzheimer's d
Autor:
Bruce A. Pappas, Nicole Sherren
Publikováno v:
Neuroscience & Biobehavioral Reviews. 27:365-376
The cholinergic immunotoxin 192 IgG-saporin can be used to effect selective, substantial and permanent lesions of basal forebrain neurons in the neonatal rat. Human neurodevelopmental disorders such as Rett and Down syndromes are characterized by ear
Autor:
Teresa Fortin, W. Dale Stevens, Steffany A. L. Bennett, Bruce A. Pappas, Christopher M. Davidson
Publikováno v:
Brain Research. 859:96-103
Adult rats underwent permanent bilateral occlusion of the common carotid arteries (2VO) to determine the effect of chronic cerebral ischemia on vision and retina. They were monitored post-surgically for the presence of the pupillary reflex to light.
Publikováno v:
Neurobiology of Aging. 21:11-17
Choline acetyltransferase activity and cognitive domain scores of Alzheimer’s patients. Item scores from the Mattis Dementia Rating Scale (MDRS) and the Mini-Mental State Examination (MMSE) from 389 patients with probable Alzheimer’s disease were
Publikováno v:
Developmental Brain Research. 114:49-62
The consequences of neonatal cholinergic lesions were examined in male and female rats. Rats were injected intraventricularly with 600 ng of 192 IgG-saporin at 7 days of age and examined behaviorally and histologically at 21, 45 and 90 days of age. 1