Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Bruce A. Littlefield"'
Publikováno v:
Cancers, Vol 14, Iss 18, p 4532 (2022)
Eribulin, a natural product-based microtubule targeting agent with cytotoxic and noncytotoxic mechanisms, is FDA approved for certain patients with advanced breast cancer and liposarcoma. To investigate the feasibility of developing drug-specific pre
Externí odkaz:
https://doaj.org/article/05213d6000aa48cd8647a3efd2c043db
Autor:
Chiara Bellio, Marta Emperador, Pol Castellano, Albert Gris-Oliver, Francesc Canals, Alex Sánchez-Pla, Esther Zamora, Joaquín Arribas, Cristina Saura, Violeta Serra, Josep Tabernero, Bruce A. Littlefield, Josep Villanueva
Publikováno v:
Cancers, Vol 14, Iss 10, p 2562 (2022)
Drug tolerant persister (DTP) cells enter into a reversible slow-cycling state after drug treatment. We performed proteomic characterization of the breast cancer (BC) DTP cell secretome after eribulin treatment. We showed that the growth differentiat
Externí odkaz:
https://doaj.org/article/a17618a9934b465d9492e07724de6193
Autor:
Patrick Schöffski, Bruce A. Littlefield, Diether Lambrechts, Amy Weaver, Elodie Modave, Bram Boeckx, Agnieszka Wozniak
Example of CNA profiles obtained in LMS. Copy-number plots: x-axis represents the position on the full genome (chromosome numbers are indicated). Red dots represent normalized read count for bins of 50Kb (log R value). Y-values around 0 represent cop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b898f8f66da61f4d38b033139c02234
https://doi.org/10.1158/1078-0432.22478406
https://doi.org/10.1158/1078-0432.22478406
Autor:
Barbara S. Slusher, Michael Polydefkis, Guido Cavaletti, Stuart C. Feinstein, Mary A. Jordan, Leslie Wilson, Christopher DesJardins, Sean Eckley, Krista Condon, Kenichi Nomoto, Bruce A. Littlefield, Brett M. Cook, Sara Semperboni, Eleonora Pozzi, Paola Alberti, Elisa Ballarini, Virginia Rodriguez-Menendez, Valentina A. Carozzi, Ying Liu, Ying Wu, James J. Vornov, Krystyna M. Wozniak
File contains description of supplementary methods used for sciatic nerve immunofluorescence data generation and quantification with Supplementary Fig 1 showing how raw fluorescence intensity values were normalized in order to compare levels of acety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c8fe14a2eaf120d0d4176f58a513a6
https://doi.org/10.1158/0008-5472.22417085
https://doi.org/10.1158/0008-5472.22417085
Autor:
Bruce A. Littlefield, Daniel Romo, Yuan Wang, Roch Boivin, Hong Du, Huiming Zhang, Yimin Jiang, Jue-Lon Shie, Zhihong Chen, Lana Parent, Natalie Twine, Sergei Agoulnik, Joanne Marsh, Nanding Zhao, Murray Towle, Junke Liu, Karen TenDyke, Lori Rudolph-Owen, Qunli Xu, Galina Kuznetsov
We report here that des-methyl, des-amino pateamine A (DMDA-PatA), a structurally simplified analogue of the marine natural product pateamine A, has potent antiproliferative activity against a wide variety of human cancer cell lines while showing rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d511a2972fe43cbe29e1cae8600cf49
https://doi.org/10.1158/1535-7163.c.6532254.v1
https://doi.org/10.1158/1535-7163.c.6532254.v1
Autor:
Patrick Schöffski, Bruce A. Littlefield, Diether Lambrechts, Amy Weaver, Elodie Modave, Bram Boeckx, Agnieszka Wozniak
Significant focal events detected in leiomyosarcoma from EISAI 309 trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a9b1a7f0e20c26a362795cceafb33f
https://doi.org/10.1158/1078-0432.22478403.v1
https://doi.org/10.1158/1078-0432.22478403.v1
Autor:
Patrick Schöffski, Bruce A. Littlefield, Diether Lambrechts, Amy Weaver, Elodie Modave, Bram Boeckx, Agnieszka Wozniak
Purpose:A randomized phase III study evaluated the efficacy of eribulin versus dacarbazine in patients with advanced liposarcoma and leiomyosarcoma. Improved overall survival (OS) led to approval of eribulin for liposarcoma, but not for leiomyosarcom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dbcb048ecd3d1b08dddd0409c6effe8
https://doi.org/10.1158/1078-0432.c.6529947
https://doi.org/10.1158/1078-0432.c.6529947
Autor:
Bruce A. Littlefield, Daniel Romo, Yuan Wang, Roch Boivin, Hong Du, Huiming Zhang, Yimin Jiang, Jue-Lon Shie, Zhihong Chen, Lana Parent, Natalie Twine, Sergei Agoulnik, Joanne Marsh, Nanding Zhao, Murray Towle, Junke Liu, Karen TenDyke, Lori Rudolph-Owen, Qunli Xu, Galina Kuznetsov
Supplementary Data from Potent in vitro and in vivo anticancer activities of des-methyl, des-amino pateamine A, a synthetic analogue of marine natural product pateamine A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a57b34d6639a87d9ea2a61f352ba72
https://doi.org/10.1158/1535-7163.22486140
https://doi.org/10.1158/1535-7163.22486140
Autor:
Barbara S. Slusher, Michael Polydefkis, Guido Cavaletti, Stuart C. Feinstein, Mary A. Jordan, Leslie Wilson, Christopher DesJardins, Sean Eckley, Krista Condon, Kenichi Nomoto, Bruce A. Littlefield, Brett M. Cook, Sara Semperboni, Eleonora Pozzi, Paola Alberti, Elisa Ballarini, Virginia Rodriguez-Menendez, Valentina A. Carozzi, Ying Liu, Ying Wu, James J. Vornov, Krystyna M. Wozniak
Chemotherapy-induced peripheral neuropathy (CIPN) is a major cause of disability in cancer survivors. CIPN investigations in preclinical model systems have focused on either behaviors or acute changes in nerve conduction velocity (NCV) and amplitude,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ede1532c2b073e39e9d7c1ef288c76
https://doi.org/10.1158/0008-5472.c.6509738
https://doi.org/10.1158/0008-5472.c.6509738
Autor:
Barbara S. Slusher, Bruce A. Littlefield, Murray J. Towle, Satoru Hosokawa, Kazuhiro Hayakawa, Guido Cavaletti, Valentina Carozzi, Ying Wu, Rena G. Lapidus, Kenichi Nomoto, Krystyna M. Wozniak
Supplementary Figures 1-2 from Comparison of Neuropathy-Inducing Effects of Eribulin Mesylate, Paclitaxel, and Ixabepilone in Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::642054b413d52e50a1b379ba1a9e2809
https://doi.org/10.1158/0008-5472.22393887.v1
https://doi.org/10.1158/0008-5472.22393887.v1