Zobrazeno 1 - 10
of 300
pro vyhledávání: '"Bruce A. Lessey"'
Autor:
Katherine B. Zutautas, Danielle J. Sisnett, Jessica E. Miller, Harshavardhan Lingegowda, Timothy Childs, Olga Bougie, Bruce A. Lessey, Chandrakant Tayade
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Endometriosis is an estrogen dominant, chronic inflammatory disease characterized by the growth of endometrial-like tissue outside of the uterus. The most common symptoms experienced by patients include manifestations of chronic pelvic pain- such as
Externí odkaz:
https://doaj.org/article/e2c1b51bd74747c2b33e61c0c0f5e971
Autor:
Jung-Yoon Yoo, Tae Hoon Kim, Jung-Ho Shin, Ryan M. Marquardt, Ulrich Müller, Asgerally T. Fazleabas, Steven L. Young, Bruce A. Lessey, Ho-Geun Yoon, Jae-Wook Jeong
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Female subfertility is highly associated with endometriosis. Here the authors show that progesterone-induced MIG-6 is reduced in endometrium of infertile women and non-human primates with endometriosis, and in a mouse model find that Erbb2 is the key
Externí odkaz:
https://doaj.org/article/e6ab3ae470b54ec4bb3069af1fbe2756
Autor:
Alison M. Sansone, Brooke V. Hisrich, R. Brandt Young, William F. Abel, Zachary Bowens, Bailey B. Blair, Avery T. Funkhouser, David P. Schammel, Lisa J. Green, Bruce A. Lessey, Anna V. Blenda
Publikováno v:
Current Issues in Molecular Biology, Vol 43, Iss 3, Pp 1350-1360 (2021)
(1) Background: Endometriosis is characterized by the presence of endometrial glands and stroma outside of the uterus and is often associated with severe pelvic pain and infertility. Our study explored the utilization of B-Cell Lymphoma 6 (BCL6) and
Externí odkaz:
https://doaj.org/article/b79dce0903f44663a80c1dd44ded9760
Autor:
Alison McCallion, Yasmin Nasirzadeh, Harshavardhan Lingegowda, Jessica E. Miller, Kasra Khalaj, SooHyun Ahn, Stephany P. Monsanto, Mallikarjun Bidarimath, Danielle J. Sisnett, Andrew W. Craig, Steven L. Young, Bruce A. Lessey, Madhuri Koti, Chandrakant Tayade
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Endometriosis is an estrogen dependent, chronic inflammatory disease characterized by the growth of endometrial lining outside of the uterus. Mast cells have emerged as key players in regulating not only allergic responses but also other mechanisms s
Externí odkaz:
https://doaj.org/article/c66825c49fe44b01b9956b2821788a31
Autor:
Jessica E. Miller, Harshavardhan Lingegowda, Lindsey K. Symons, Olga Bougie, Steven L. Young, Bruce A. Lessey, Madhuri Koti, Chandrakant Tayade
Publikováno v:
JCI Insight, Vol 6, Iss 23 (2021)
Chronic inflammation and localized alterations in immune cell function are suspected to contribute to the progression of endometriosis and its associated symptoms. In particular, the alarmin IL-33 is elevated in the plasma, peritoneal fluid, and endo
Externí odkaz:
https://doaj.org/article/eeb9d1a38e644ceb8e820883b45d1e20
Autor:
Xiaoqiu Wang, Xilong Li, Tianyuan Wang, San-Pin Wu, Jae-Wook Jeong, Tae Hoon Kim, Steven L. Young, Bruce A. Lessey, Rainer B. Lanz, John P. Lydon, Francesco J. DeMayo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The transcription factor SOX17 is important for uterine gland formation, fertility, and embryo implantation in mouse. Here the authors show that SOX17 is upstream of Indian hedgehog to regulate mouse uterine receptivity, and their analysis of uterine
Externí odkaz:
https://doaj.org/article/c127c07db61c403ebeb300e9a82a357d
Autor:
Jung-Yoon Yoo, Tae Hoon Kim, Asgerally T. Fazleabas, Wilder A. Palomino, Soo Hyun Ahn, Chandrakant Tayade, David P. Schammel, Steven L. Young, Jae-Wook Jeong, Bruce A. Lessey
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Endometriosis is an inflammatory condition that is associated with progesterone resistance and cell proliferation, resulting in pain, infertility and pregnancy loss. We previously demonstrated phosphorylation of STAT3 in eutopic endometrium
Externí odkaz:
https://doaj.org/article/8511e65b6d0145d4b9e1880673eb0c3f
Autor:
Kasra Khalaj, Soo Hyun Ahn, Mallikarjun Bidarimath, Yasmin Nasirzadeh, Sukhbir S. Singh, Asgerally T. Fazleabas, Steven L. Young, Bruce A. Lessey, Madhuri Koti, Chandrakant Tayade
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Endometriosis, a major reproductive pathology affecting 8–10% of women is characterized by chronic inflammation and immune dysfunction. Human antigen R (HuR) and Tristetraprolin (TTP) are RNA binding proteins that competitively bind to cyt
Externí odkaz:
https://doaj.org/article/7624af9b99e044b28c2c2981b2563cdf
Autor:
Brooke V. Hisrich, R. Brant Young, Alison M. Sansone, Zachary Bowens, Lisa J. Green, Bruce A. Lessey, Anna V. Blenda
Publikováno v:
Biomolecules, Vol 10, Iss 2, p 230 (2020)
Galectins are a family of β-galactoside-binding proteins that contribute to multiple cellular functions, including immune surveillance and apoptosis. Human galectins are also important regulators of inflammation, making them a research target for va
Externí odkaz:
https://doaj.org/article/a68dad8d96b44c228980ed84444cf5e2
Postmenopausal Deep Infiltrating Endometriosis of the Colon: Rare Location and Novel Medical Therapy
Publikováno v:
Case Reports in Gastrointestinal Medicine, Vol 2018 (2018)
We report an uncommon case of deep infiltrating endometriosis of the colon presenting as iron deficiency anemia nine years after hysterectomy with bilateral salpingo-oophorectomy. The endometrial implant was found at the hepatic flexure, an exceeding
Externí odkaz:
https://doaj.org/article/360cd501a78c46098125a16bb18a0cff