Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Bruce A. Hirayama"'
Autor:
Chiara Ghezzi, Bruce A. Hirayama, Jorge R. Barrio, Vladimir Kepe, Jie Liu, Monica Sala-Rabanal, Ernest M. Wright
Publikováno v:
The Journal of Physiology. 596:2473-2489
Author(s): Sala-Rabanal, Monica; Ghezzi, Chiara; Hirayama, Bruce A; Kepe, Vladimir; Liu, Jie; Barrio, Jorge R; Wright, Ernest M | Abstract: KEY POINTS:The goal was to determine the importance of the sodium-glucose cotransporter SGLT1 and the glucose
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 46
Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 46
Significance Site-directed fluorometry was used to understand conformational changes of the Na+/glucose symporter. SGLT1 functions by a mechanism where the substrate-binding site alternates between the two faces of the membrane, but little is known a
Autor:
David R. Powell, Amy S. Yu, Nagichettiar Satyamurthy, Sung-Cheng Huang, Bruce A. Hirayama, Jie Liu, Jorge R. Barrio, Claudio Scafoglio, Vladimir Kepe, Ernest M. Wright, Chiara Ghezzi
Publikováno v:
Ghezzi, C; Yu, AS; Hirayama, BA; Kepe, V; Liu, J; Scafoglio, C; et al.(2017). Dapagliflozin Binds Specifically to Sodium-Glucose Cotransporter 2 in the Proximal Renal Tubule. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 28(3), 802-810. doi: 10.1681/ASN.2016050510. UCLA: Retrieved from: http://www.escholarship.org/uc/item/2840m508
Journal of the American Society of Nephrology : JASN, vol 28, iss 3
Journal of the American Society of Nephrology : JASN, vol 28, iss 3
Kidneys contribute to glucose homeostasis by reabsorbing filtered glucose in the proximal tubules via sodium-glucose cotransporters (SGLTs). Reabsorption is primarily handled by SGLT2, and SGLT2-specific inhibitors, including dapagliflozin, canaglifl
Autor:
David R. Powell, Sung-Cheng Huang, Bruce A. Hirayama, Hermann Koepsell, Amy S. Yu, Bernard Thorens, Vladimir Kepe, Chiara Ghezzi, Jorge R. Barrio, Jie Liu, Monica Sala-Rabanal, Ernest M. Wright
Publikováno v:
The Journal of Physiology. 594:4425-4438
Glucose transporters are central players in glucose homeostasis. There are two major classes of glucose transporters in the body, the passive facilitative glucose transporters (GLUTs) and the secondary active sodium-coupled glucose transporters (SGLT
Publikováno v:
Biochemistry. 51:9480-9487
In the LeuT family of sodium solute symporters, 13-17% of the residues in transmembrane domains are aromatic. The unique properties of aromatic amino acids allow them to play specialized roles in proteins, but their function in membrane transporters
Autor:
Bruce A. Hirayama, Jeff Abramson, Monica Sala-Rabanal, Donald D. F. Loo, Ernest M. Wright, Vincent Chaptal
Publikováno v:
American Journal of Physiology-Cell Physiology. 302:C1293-C1305
The Na+-glucose cotransporter hSGLT1 is a member of a class of membrane proteins that harness Na+electrochemical gradients to drive uphill solute transport. Although hSGLT1 belongs to one gene family (SLC5), recent structural studies of bacterial Na+
Autor:
Charles S. Hummel, Vladimir Kepe, Ernest M. Wright, Chuan Lu, Chiari Ghezzi, Bruce A. Hirayama, Jorge R. Barrio, Jie Liu, Donald D. F. Loo
Publikováno v:
Am J Physiol Cell Physiol.
Human Na+-d-glucose cotransporter (hSGLT) inhibitors constitute the newest class of diabetes drugs, blocking up to 50% of renal glucose reabsorption in vivo. These drugs have potential for widespread use in the diabetes epidemic, but how they work at
Publikováno v:
American Journal of Physiology-Renal Physiology. 294:F1422-F1432
The human proton/oligopeptide cotransporters hPEPT1 and hPEPT2 have been targeted to enhance the bioavailability of drugs and prodrugs. Previously, we established the mechanisms of drug transport by hPEPT1. Here, we extend these studies to hPEPT2. Ma
Publikováno v:
Journal of Membrane Biology. 223:87-106
Drugs are transported by cotransporters with widely different turnover rates. We have examined the underlying mechanism using, as a model system, glucose and indican (indoxyl-beta-D-glucopyranoside) transport by human Na+/glucose cotransporter (hSGLT
Publikováno v:
Journal of Internal Medicine. 261:32-43
Secondary active glucose transport occurs by at least four members of the SLC5 gene family. This review considers the structure and function of two premier members, SGLT1 and SGLT2, and their role in intestinal glucose absorption and renal glucose re