Zobrazeno 1 - 10
of 425
pro vyhledávání: '"Bruce A. Freeman"'
Autor:
Valerie B. O’Donnell, Nils H. Schebb, Ginger L. Milne, Michael P. Murphy, Christopher P. Thomas, Dieter Steinhilber, Stacy L. Gelhaus, Hartmut Kühn, Michael H. Gelb, Per-Johan Jakobsson, Ian A. Blair, Robert C. Murphy, Bruce A. Freeman, Alan R. Brash, Garret A. FitzGerald
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-5 (2023)
Externí odkaz:
https://doaj.org/article/be32bdf8db4a483a9d4567d68f0e996c
Autor:
Fabliha A. Chowdhury, Nicole Colussi, Malini Sharma, Katherine C. Wood, Julia Z. Xu, Bruce A. Freeman, Francisco J. Schopfer, Adam C. Straub
Publikováno v:
Redox Biology, Vol 68, Iss , Pp 102941- (2023)
Sickle cell disease (SCD) is a hereditary hematological disease with high morbidity and mortality rates worldwide. Despite being monogenic, SCD patients display a plethora of disease-associated complications including anemia, oxidative stress, steril
Externí odkaz:
https://doaj.org/article/e1bc2e80353f4d6091066d02a5726433
Autor:
Roberto Di Maio, Matthew T. Keeney, Veronika Cechova, Amanda Mortimer, Ahssan Sekandari, Pascal Rowart, J. Timothy Greenamyre, Bruce A. Freeman, Marco Fazzari
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract To date there are no therapeutic strategies that limit the progression of Parkinson’s disease (PD). The mechanisms underlying PD-related nigrostriatal neurodegeneration remain incompletely understood, with multiple factors modulating the c
Externí odkaz:
https://doaj.org/article/5eee1875d5414f4f93c5537ba12898e0
Autor:
Lisa Hong, Dennis C. Braden, Yaoning Zhao, John J. Skoko, Fei Chang, Steven R. Woodcock, Crystall Uvalle, Allison Casey, Katherine Wood, Sonia R. Salvatore, Alparslan Asan, Trey Harkness, Adeola Fagunloye, Mortezaali Razzaghi, Adam Straub, Maria Spies, Daniel D. Brown, Adrian V. Lee, Francisco Schopfer, Bruce A. Freeman, Carola A. Neumann
Publikováno v:
Redox Biology, Vol 66, Iss , Pp 102856- (2023)
Nitro fatty acids (NO2-FAs) are endogenously generated lipid signaling mediators from metabolic and inflammatory reactions between conjugated diene fatty acids and nitric oxide or nitrite-derived reactive species. NO2-FAs undergo reversible Michael a
Externí odkaz:
https://doaj.org/article/74e2d4a459964b33908f0fc33cbe7493
Autor:
Victoria A. Heinrich, Crystal Uvalle, Michelle L. Manni, Kelvin Li, Steven J. Mullett, Sri Ramya Donepudi, Jason Clader, Adam Fitch, Madeline Ellgass, Veronika Cechova, Shulin Qin, Fernando Holguin, Bruce A. Freeman, Barbara A. Methé, Alison Morris, Stacy L. Gelhaus
Publikováno v:
Frontiers in Microbiomes, Vol 2 (2023)
Obesity and associated changes to the gut microbiome worsen airway inflammation and hyperresponsiveness in asthma. Obesogenic host-microbial metabolomes have altered production of metabolites that may influence lung function and inflammatory response
Externí odkaz:
https://doaj.org/article/ca9aa240e77746a392708e4e1d31ec30
Autor:
Michelle L. Manni, Victoria A. Heinrich, Gregory J. Buchan, James P. O’Brien, Crystal Uvalle, Veronika Cechova, Adolf Koudelka, Dharti Ukani, Mohamad Rawas-Qalaji, Tim D. Oury, Renee Hart, Madeline Ellgass, Steven J. Mullett, Merritt L. Fajt, Sally E. Wenzel, Fernando Holguin, Bruce A. Freeman, Stacy G. Wendell
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Bile acid profiles are altered in obese individuals with asthma. Thus, we sought to better understand how obesity-related systemic changes contribute to lung pathophysiology. We also test the therapeutic potential of nitro-oleic acid (NO2-OA
Externí odkaz:
https://doaj.org/article/40111bfc71bc4fc1b5f339c0101d5c5d
Autor:
Adolf Koudelka, Veronika Cechova, Mauricio Rojas, Nilay Mitash, Anna Bondonese, Claudette St. Croix, Mark A. Ross, Bruce A. Freeman
Publikováno v:
Redox Biology, Vol 50, Iss , Pp 102226- (2022)
Tissue fibrosis occurs in response to dysregulated metabolism, pro-inflammatory signaling and tissue repair reactions. For example, lungs exposed to environmental toxins, cancer therapies, chronic inflammation and other stimuli manifest a phenotypic
Externí odkaz:
https://doaj.org/article/35581b9bda244c64a72292eaba451e09
Autor:
Peng Wang, Meaghan E. Killeen, Tina L. Sumpter, Laura K. Ferris, Louis D. Falo, Jr., Bruce A. Freeman, Francisco J. Schopfer, Alicia R. Mathers
Publikováno v:
Redox Biology, Vol 43, Iss , Pp 101987- (2021)
Psoriasis is a chronic inflammatory skin disease with no cure. Although the origin of psoriasis and its underlying pathophysiology remain incompletely understood, inflammation is a central mediator of disease progression. In this regard, electrophili
Externí odkaz:
https://doaj.org/article/4b0d7cf207144e3e87124caa4fa7109b
Autor:
Stephanie L. Daugherty, Jonathan M. Beckel, Kyoungeun A. Kim, Bruce A. Freeman, Jiaxin Liu, Shaoyong Wang, William C. de Groat, Xiulin Zhang
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Activation of TRP channels expressed in urinary bladder afferent nerves and urothelium releases neurotransmitters that influence bladder function. Experiments were undertaken to examine the mechanisms underlying effects of TRPA1 (allyl isothiocyanate
Externí odkaz:
https://doaj.org/article/06b4a14dbd334bba8ae0608b28b63a92
Autor:
Marco Fazzari, Steven R. Woodcock, Pascal Rowart, Karina Ricart, Jack R. Lancaster, Jr., Rakesh Patel, Dario A. Vitturi, Bruce A. Freeman, Francisco J. Schopfer
Publikováno v:
Redox Biology, Vol 41, Iss , Pp 101913- (2021)
Organic nitrate esters, long-recognized therapies for cardiovascular disorders, have not been detected biologically. We characterize in rat stomach unsaturated fatty acid nitration reactions that proceed by generation of nitro-nitrate intermediates (
Externí odkaz:
https://doaj.org/article/6ea57f2bc8e24cff85cf0065be293b6a