Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Bruce A Yankner"'
Autor:
Liviu Aron, Chenxi Qiu, Zhen Kai Ngian, Marianna Liang, Derek Drake, Jaejoon Choi, Marty A. Fernandez, Perle Roche, Emma L. Bunting, Ella K. Lacey, Sara E. Hamplova, Monlan Yuan, Michael S. Wolfe, David A. Bennett, Eunjung A. Lee, Bruce A. Yankner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Many aging individuals accumulate the pathology of Alzheimer’s disease (AD) without evidence of cognitive decline. Here we describe an integrated neurodegeneration checkpoint response to early pathological changes that restricts further di
Externí odkaz:
https://doaj.org/article/e84a41f3caaa44a194226f2627e04640
Autor:
Elaine T. Lim, Yingleong Chan, Pepper Dawes, Xiaoge Guo, Serkan Erdin, Derek J. C. Tai, Songlei Liu, Julia M. Reichert, Mannix J. Burns, Ying Kai Chan, Jessica J. Chiang, Katharina Meyer, Xiaochang Zhang, Christopher A. Walsh, Bruce A. Yankner, Soumya Raychaudhuri, Joel N. Hirschhorn, James F. Gusella, Michael E. Talkowski, George M. Church
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Cerebral organoids can be used to gain insights into neuropsychiatric disorders. Here the authors carry out RNAseq characterization from organoids derived from donors with autism spectrum disorder to identify associated cell type specific driver gene
Externí odkaz:
https://doaj.org/article/95de5f4e0e584e9ba9efd47fbab020ce
Autor:
Katharina Meyer, Heather M. Feldman, Tao Lu, Derek Drake, Elaine T. Lim, King-Hwa Ling, Nicholas A. Bishop, Ying Pan, Jinsoo Seo, Yuan-Ta Lin, Susan C. Su, George M. Church, Li-Huei Tsai, Bruce A. Yankner
Publikováno v:
Cell Reports, Vol 26, Iss 5, Pp 1112-1127.e9 (2019)
Summary: The molecular basis of the earliest neuronal changes that lead to Alzheimer’s disease (AD) is unclear. Here, we analyze neural cells derived from sporadic AD (SAD), APOE4 gene-edited and control induced pluripotent stem cells (iPSCs). We o
Externí odkaz:
https://doaj.org/article/badcc8e4bd05429e89f06087a8cb13bb
Publikováno v:
Curr Opin Neurobiol
The aging brain is shaped by many structural and functional alterations. Recent cross-disciplinary efforts have uncovered powerful and integrated adaptive mechanisms that promote brain health and prevent functional decline during aging. Here, we revi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6a943f56cf898fefce151ff3b81c17
https://doi.org/10.1016/j.conb.2021.09.009
https://doi.org/10.1016/j.conb.2021.09.009
Autor:
Bruce A. Yankner, Liviu Aron, Christophe Legendre, Fabiola Terzi, Guillaume Canaud, Clément Hoguin, Pierre Isnard, Sato Magassa
Publikováno v:
J Am Soc Nephrol
Background Chronic kidney disease is associated with the loss of functional nephrons, leading to increased mechanical and metabolic stress in the remaining cells, particularly for cells constituting the filtration barrier, such as podocytes. The fail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8170eedc24fb40dac9de11b91ef8a8ff
https://doi.org/10.1681/asn.2021020231
https://doi.org/10.1681/asn.2021020231
Autor:
Yiyuan Xia, Hiroshi Qadota, Zhi-Hao Wang, Pai Liu, Xia Liu, Karen X. Ye, Courtney J. Matheny, Ken Berglund, Shan Ping Yu, Derek Drake, David A. Bennett, Xiao-Chuan Wang, Bruce A. Yankner, Guy M. Benian, Keqiang Ye
Publikováno v:
Science Advances. 8
The age-related cognitive decline of normal aging is exacerbated in neurodegenerative diseases including Alzheimer’s disease (AD). However, it remains unclear whether age-related cognitive regulators in AD pathologies contribute to life span. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965a636fee52c847830b4fd4c6b16665
https://doi.org/10.1126/sciadv.abj8658
https://doi.org/10.1126/sciadv.abj8658
Autor:
Monica P. Colaiácovo, Bruce A. Yankner, Joseph M. Zullo, David A. Bennett, William H. Klein, Derek Drake, Patrick O’Hern, Noah Davidsohn, Sameer C. Dhamne, Liviu Aron, Chai An Mao, George M. Church, Alexander Rotenberg
Publikováno v:
Nature
The mechanisms that extend lifespan in humans are poorly understood. Here we show that extended longevity in humans is associated with a distinct transcriptome signature in the cerebral cortex that is characterized by downregulation of genes related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1f4c9e899ecb12eaf11ee13d60691c
https://doi.org/10.1038/s41586-019-1647-8
https://doi.org/10.1038/s41586-019-1647-8
Autor:
Kunal Jindal, Je-Hyuk Lee, Daniel Goodwin, Thomas C. Ferrante, Conor K. Camplisson, George M. Church, Shahar Alon, Eswar Prasad Ramachandran Iyer, Lauren Mifflin, Anne Cheng, Bruce A. Yankner, Richie E. Kohman, Edward S. Boyden, Songlei Liu, King Hwa Ling, Valerie Willocq, Sukanya Punthambaker, Katharina Meyer, John Aach, Jenny M. Tam, Asmamaw T Wassie, Fei Chen, Daniel Fürth, Anubhav Sinha, Andrew C. Pawlowski
Publikováno v:
Nucleic Acids Research
We present barcoded oligonucleotides ligated on RNA amplified for multiplexed and parallel insitu analyses (BOLORAMIS), a reverse transcription-free method for spatially-resolved, targeted, in situ RNA identification of single or multiple targets. BO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b3378a2ccf575769ac6816ac6a070e
https://pubmed.ncbi.nlm.nih.gov/33693773
https://pubmed.ncbi.nlm.nih.gov/33693773
Autor:
Julia M. Reichert, Bruce A. Yankner, Elaine T. Lim, Katharina Meyer, Mannix J. Burns, Serkan Erdin, Ying Kai Chan, Derek J. C. Tai, Joel N. Hirschhorn, Yingleong Chan, Xiaoge Guo, James F. Gusella, Christopher T. Walsh, Michael E. Talkowski, Soumya Raychaudhuri, Xiaochang Zhang, Jessica J. Chiang, George M. Church
Human-derived cerebral organoids demonstrate great promise for identifying cell types and cell type specific molecular processes perturbed by genetic variants associated with neuropsychiatric and neurodevelopmental disorders, which are notoriously ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48f13a662abed2f28d5b3c0d65f4f79b
https://doi.org/10.21203/rs.3.rs-113869/v1
https://doi.org/10.21203/rs.3.rs-113869/v1
Autor:
George M. Church, Derek J. C. Tai, Soumya Raychaudhuri, Katharina Meyers, Xiaoge Guo, Bruce A. Yankner, Michael E. Talkowski, Elaine T. Lim, James F. Gusella, Christopher A. Walsh, Yingleong Chan, Mannix J. Burns, Julia M. Reichert, Joel N. Hirschhorn, Ying Kai Chan, Xiaochang Zhang, Jessica J. Chiang, Serkan Erdin
Neuropsychiatric and neurodevelopmental disorders have been particularly challenging to study using animal models, and recently, human-derived cerebral organoids demonstrate great promise for discovering molecular processes that are important in thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc04d41c7becc3600a47e74ebb8370c9
https://doi.org/10.1101/2020.11.15.375386
https://doi.org/10.1101/2020.11.15.375386