Zobrazeno 1 - 10
of 246
pro vyhledávání: '"Bruce A Sullenger"'
Autor:
Lingye Chen, Lyra B. Olson, Ibtehaj A. Naqvi, Bruce A. Sullenger, Loretta G. Que, Thomas N. Denny, Bryan D. Kraft
Publikováno v:
BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-8 (2024)
Abstract Background Severe COVID-19 carries a high morbidity and mortality. Previous studies have shown an association between COVID-19 severity and SARS-CoV-2 viral load (VL). We sought to measure VL in multiple compartments (urine, plasma, lower re
Externí odkaz:
https://doaj.org/article/8a7d334a2f224a689d615104e20f3409
Autor:
Haixiang Yu, Shekhar Kumar, James W. Frederiksen, Vladimir N. Kolyadko, George Pitoc, Juliana Layzer, Amy Yan, Rachel Rempel, Samuel Francis, Sriram Krishnaswamy, Bruce A. Sullenger
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Potent and selective inhibition of the structurally homologous proteases of coagulation poses challenges for drug development. Hematophagous organisms frequently accomplish this by fashioning peptide inhibitors combining exosite and active s
Externí odkaz:
https://doaj.org/article/7a6f52c557ba4dfcb62c6ee0bf629bf7
Autor:
Jing Mi, Partha Ray, Jenny Liu, Chien-Tsun Kuan, Jennifer Xu, David Hsu, Bruce A Sullenger, Rebekah R White, Bryan M Clary
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
The ability to selectively target disease-related tissues with molecules is critical to the design of effective therapeutic and diagnostic reagents. Recognizing the differences between the in vivo environment and in vitro conditions, we employed an i
Externí odkaz:
https://doaj.org/article/636358dbe79741cb834010759a1ec9d5
Autor:
Jonathan W Kotula, Jinpeng Sun, Margie Li, Elizabeth D Pratico, Mark P Fereshteh, Douglas P Ahrens, Bruce A Sullenger, Jeffrey J Kovacs
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93441 (2014)
β-arrestins, ubiquitous cellular scaffolding proteins that act as signaling mediators of numerous critical cellular pathways, are attractive therapeutic targets because they promote tumorigenesis in several tumor models. However, targeting scaffoldi
Externí odkaz:
https://doaj.org/article/7ce1189f7327432ca44eeedd8f568bb1
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69413 (2013)
Toll-like receptor (TLR) family members, 3, 7 and 9 are key components in initiation and progression of autoimmune disorders such as systemic lupus erythematosus (SLE). These TLRs are often referred to as nucleic acid-sensing TLRs based on their abil
Externí odkaz:
https://doaj.org/article/b936275ddb4b4c46aa767d79f461438e
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40862 (2012)
Antibodies to DNA (anti-DNA) are the serological hallmark of systemic lupus erythematosus (SLE) and can mediate disease pathogenesis by the formation of immune complexes. Since blocking immune complex formation can attenuate disease manifestations, t
Externí odkaz:
https://doaj.org/article/04a52858cab94b828ce2937d1eff4c45
Autor:
Bryan D. Kraft, Simon Verhulst, Tsung-Po Lai, Bruce A. Sullenger, Yunfei Wang, Wes Rountree, Lingye Chen, Christopher W. Woods, Thomas N. Denny, Abraham Aviv
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Lymphocyte telomere length (TL) is highly variable and shortens with age. Short telomeres may impede TL-dependent T-cell clonal expansion with viral infection. As SARS-CoV-2 infection can induce prolonged and severe T-cell lymphopenia, infected adult
Externí odkaz:
https://doaj.org/article/bd2de7c301b943aabb522de074b07aac
Autor:
Bethany Powell Gray, Linsley Kelly, Kady-Ann Steen-Burrell, Juliana M. Layzer, Rachel E. Rempel, Shahid M. Nimjee, Brian C. Cooley, Alice F. Tarantal, Bruce A. Sullenger
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 440-451 (2023)
Pathological blood clotting, or thrombosis, limits vital blood flow to organs; such deprivation can lead to catastrophic events including myocardial infarction, pulmonary embolism, and ischemic stroke. Prompt restoration of blood flow greatly improve
Externí odkaz:
https://doaj.org/article/1ee17a94201144fc8700f739b611a006
Autor:
Francesco Puzzo, Chuanling Zhang, Bethany Powell Gray, Feijie Zhang, Bruce A. Sullenger, Mark A. Kay
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 383-397 (2023)
Adeno-associated viruses (AAVs) are commonly used for in vivo gene therapy. Nevertheless, the wide tropism that characterizes these vectors limits specific targeting to a particular cell type or tissue. Here, we developed new chemically modified AAV
Externí odkaz:
https://doaj.org/article/2cb14785ab9043a29a90dad688519651
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102348- (2023)
Summary: Cell isolation from complex mixtures is a key step in many clinical and research applications, but standard isolation methods may affect the cell’s biology and are difficult to reverse. Here, we present a method to isolate and restore cell
Externí odkaz:
https://doaj.org/article/c2eb9f52ea394b57b6bb6eb24749dfe3