Zobrazeno 1 - 10
of 451
pro vyhledávání: '"Bruce A Shapiro"'
Autor:
My-Tra Le, Wojciech K Kasprzak, Taejin Kim, Feng Gao, Megan YL Young, Xuefeng Yuan, Bruce A Shapiro, Joonil Seog, Anne E Simon
Publikováno v:
eLife, Vol 6 (2017)
Turnip crinkle virus contains a T-shaped, ribosome-binding, translation enhancer (TSS) in its 3’UTR that serves as a hub for interactions throughout the region. The viral RNA-dependent RNA polymerase (RdRp) causes the TSS/surrounding region to unde
Externí odkaz:
https://doaj.org/article/8c74356cd4e8482fa9a774dd09782c15
Autor:
Saleh Tamim, Dat T Vo, Philip J Uren, Mei Qiao, Eckart Bindewald, Wojciech K Kasprzak, Bruce A Shapiro, Helder I Nakaya, Suzanne C Burns, Patricia R Araujo, Ichiro Nakano, Agnes J Radek, Scott Kuersten, Andrew D Smith, Luiz O F Penalva
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85591 (2014)
miR-137 plays critical roles in the nervous system and tumor development; an increase in its expression is required for neuronal differentiation while its reduction is implicated in gliomagenesis. To evaluate the potential of miR-137 in glioblastoma
Externí odkaz:
https://doaj.org/article/07dfca16fddd4fbc9d890bfd951dd082
Autor:
Taejin Kim, Kirill A. Afonin, Mathias Viard, Alexey Y Koyfman, Selene Sparks, Eliahu Heldman, Sarina Grinberg, Charles Linder, Robert P Blumenthal, Bruce A Shapiro
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
Specific small interfering RNAs (siRNAs) designed to silence different oncogenic pathways can be used for cancer therapy. However, non-modified naked siRNAs have short half-lives in blood serum and encounter difficulties in crossing biological membra
Externí odkaz:
https://doaj.org/article/d85cc7457486442b920c8a084c31aba4
Autor:
Christine Vogel, Raquel de Sousa Abreu, Daijin Ko, Shu‐Yun Le, Bruce A Shapiro, Suzanne C Burns, Devraj Sandhu, Daniel R Boutz, Edward M Marcotte, Luiz O Penalva
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp n/a-n/a (2010)
Transcription, mRNA decay, translation and protein degradation are essential processes during eukaryotic gene expression, but their relative global contributions to steady‐state protein concentrations in multi‐cellular eukaryotes are largely unkn
Externí odkaz:
https://doaj.org/article/dc169829b87448dca54dcc55130b453c
Autor:
Yih-Horng Shiao, Sorin T Lupascu, Yuhan D Gu, Wojciech Kasprzak, Christopher J Hwang, Janet R Fields, Robert M Leighty, Octavio Quiñones, Bruce A Shapiro, W Gregory Alvord, Lucy M Anderson
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7505 (2009)
Ribosomal RNA (rRNA) is a central regulator of cell growth and may control cancer development. A cis noncoding rRNA (nc-rRNA) upstream from the 45S rRNA transcription start site has recently been implicated in control of rRNA transcription in mouse f
Externí odkaz:
https://doaj.org/article/8f2e7461c53b47b7b36b8ffa0babccbc
Autor:
Arti N Santhanam, Eckart Bindewald, Vinagolu K Rajasekhar, Ola Larsson, Nahum Sonenberg, Nancy H Colburn, Bruce A Shapiro
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4868 (2009)
Eukaryotic cap-dependent mRNA translation is mediated by the initiation factor eIF4E, which binds mRNAs and stimulates efficient translation initiation. eIF4E is often overexpressed in human cancers. To elucidate the molecular signature of eIF4E targ
Externí odkaz:
https://doaj.org/article/62e38b4c79bb44c0848a386f18814a93
Publikováno v:
British Journal of Haematology. 200:377-380
Despite recent developmental screening guidelines, rates of neurodevelopmental disorders (NDDs) remain lower than expected in children with sickle cell disease (SCD). A retrospective chart review identified 276 eligible patients; 214 charts were avai
Autor:
Bruce S, Shapiro, Melody A, Rasouli, Kajal, Verma, Ankita, Raman, Forest C, Garner, Martha, Aguirre, Leah, Kaye, Carrie, Bedient
Publikováno v:
Fertility and Sterility. 117:1170-1176
To identify relationships between the size of punctured ovarian follicles and subsequent embryology outcomes.Prospective observational cohort study.Private fertility center.One hundred fifty-seven oocyte retrievals performed during the study period.T
Autor:
Lukasz T. Olenginski, Wojciech K. Kasprzak, Solomon K. Attionu, Bruce A. Shapiro, Theodore K. Dayie
Publikováno v:
Molecules
Volume 28
Issue 4
Pages: 1803
Volume 28
Issue 4
Pages: 1803
The global burden imposed by hepatitis B virus (HBV) infection necessitates the discovery and design of novel antiviral drugs to complement existing treatments. One attractive and underexploited therapeutic target is ε, an ~85-nucleotide (nt) cis-ac
Publikováno v:
Nucleic Acids Research. 50:1601-1619
Canonical eukaryotic mRNA translation requires 5′cap recognition by initiation factor 4E (eIF4E). In contrast, many positive-strand RNA virus genomes lack a 5′cap and promote translation by non-canonical mechanisms. Among plant viruses, PTEs are