Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Bruce A, Palfey"'
Autor:
Charles Bou-Nader, Frederick W. Stull, Ludovic Pecqueur, Philippe Simon, Vincent Guérineau, Antoine Royant, Marc Fontecave, Murielle Lombard, Bruce A. Palfey, Djemel Hamdane
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
The bacterial thymidylate synthase ThyX catalyzes the reductive methylation of deoxyuridylate (dUMP) into deoxythymidylate (dTMP) and requires both folate and flavin for activity. Here, the authors combine biochemical experiments, spectroscopic measu
Externí odkaz:
https://doaj.org/article/9d2804fa1f2e4892889a444777040660
Autor:
Rebecca L. Switzer, Bruce A. Palfey
Publikováno v:
ACS In Focus ISBN: 9780841299399
ACS In Focus
ACS In Focus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5da45651be33bc108ff17164d3282149
https://doi.org/10.1021/acsinfocus.7e5015
https://doi.org/10.1021/acsinfocus.7e5015
Autor:
Kim D. Janda, Manaswni Dhingra, Margarita A. Tararina, Karen N. Allen, Katie K. Dam, Bruce A. Palfey
Publikováno v:
Biochemistry. 60(4)
In Pseudomonas putida, the flavoprotein nicotine oxidoreductase (NicA2) catalyzes the oxidation of (S)-nicotine to N-methyl-myosmine, which is nonenzymatically hydrolyzed to pseudooxynicotine. Structural analysis reveals a monoamine oxidase (MAO)-lik
Autor:
Bruce A. Palfey, Charles Bou-Nader, Antoine Royant, Ludovic Pecqueur, Philippe Simon, Vincent Guérineau, Frederick Stull, Djemel Hamdane, Murielle Lombard, Marc Fontecave
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12, pp.4542. ⟨10.1038/s41467-021-24756-8⟩
Nature Communications, 2021, 12, pp.4542. ⟨10.1038/s41467-021-24756-8⟩
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
'Nature Communications ', vol: 12, pages: 4542-1-4542-8 (2021)
Nature Communications, Nature Publishing Group, 2021, 12, pp.4542. ⟨10.1038/s41467-021-24756-8⟩
Nature Communications, 2021, 12, pp.4542. ⟨10.1038/s41467-021-24756-8⟩
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
'Nature Communications ', vol: 12, pages: 4542-1-4542-8 (2021)
Folate enzyme cofactors and their derivatives have the unique ability to provide a single carbon unit at different oxidation levels for the de novo synthesis of amino-acids, purines, or thymidylate, an essential DNA nucleotide. How these cofactors me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6abb4e0323bc9955acc523353f09eb4
https://hal.sorbonne-universite.fr/hal-03343627
https://hal.sorbonne-universite.fr/hal-03343627
Autor:
Kyle L. Ferguson, David P. Ballou, Brandon T. Ruotolo, April K Kaneshiro, Bruce A. Palfey, E. Neil G. Marsh, Karl J. Koebke, Chunyi Zhao
Publikováno v:
Biochemistry. 60(2)
Ferulic acid decarboxylase catalyzes the decarboxylation of various substituted phenylacrylic acids to their corresponding styrene derivatives and CO2 using the recently discovered cofactor prenylated FMN (prFMN). The mechanism involves an unusual 1,
Publikováno v:
Journal of the American Chemical Society. 142(4)
Heteroaromatic sulfones react with cysteine via nucleophilic aromatic substitution, providing a mechanistically selective and irreversible scaffold for cysteine conjugation. Here we evaluate a library of heteroaromatic sulfides with different oxidati
Publikováno v:
Trends in Biochemical Sciences. 42:457-469
With approximately 1% of proteins being flavoproteins, flavins are at the heart of a plethora of redox reactions in all areas of biology. Thanks to a series of fascinating recent discoveries, in addition to redox chemistry, covalent catalysis is now
Autor:
Aparna Sapra, Erik R. P. Zuiderweg, Steffen M. Bernard, Janet L. Smith, Bruce A. Palfey, Frederick Stull
Publikováno v:
Biochemistry. 55:3261-3269
Many microorganisms use flavin-dependent thymidylate synthase (FDTS) to synthesize the essential nucleotide 2'-deoxythymidine 5'-monophosphate (dTMP) from 2'-deoxyuridine 5'-monophosphate (dUMP), 5,10-methylenetetrahydrofolate (CH2THF), and NADPH. FD
Flavin binding affinity and initial kinetic characterization of DnmZ, a flavin‐dependent N‐oxygenase
Autor:
Taylor Hardin, Nadia Castillejo, Katherine Huynh, Lucero Guzman, Bruce A. Palfey, Jessica L. Vey
Publikováno v:
The FASEB Journal. 34:1-1