Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Bruce Carrington"'
Autor:
Alexander Vugler, James O’Connell, Mai Anh Nguyen, Dietmar Weitz, Thomas Leeuw, Elizabeth Hickford, Alexander Verbitsky, Xiaoyou Ying, Markus Rehberg, Bruce Carrington, Mark Merriman, Andrew Moss, Jean-Marie Nicholas, Phil Stanley, Sara Wright, Tim Bourne, Yann Foricher, Daniel Brookings, Helen Horsley, Matthias Herrmann, Srinivas Rao, Markus Kohlmann, Peter Florian
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Tumor necrosis factor (TNF) is a pleiotropic cytokine belonging to a family of trimeric proteins with both proinflammatory and immunoregulatory functions. TNF is a key mediator in autoimmune diseases and during the last couple of decades several biol
Externí odkaz:
https://doaj.org/article/1ee03f08f53b498dba01c240aad2ca37
Autor:
Daniel J. Lightwood, Rebecca J. Munro, John Porter, David McMillan, Bruce Carrington, Alison Turner, Anthony Scott-Tucker, Elizabeth S. Hickford, Antje Schmidt, David Fox, Alison Maloney, Tom Ceska, Tim Bourne, James O’Connell, Alastair D. G. Lawson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
TNF can be inhibited by small molecules that stabilize the TNF trimer in an asymmetric conformation. Here, the authors develop a monoclonal antibody that selectively binds this inactive form of TNF, enabling both target engagement assessment and stru
Externí odkaz:
https://doaj.org/article/a700e6f6d0e341fa8bbbdf0203d53866
Autor:
David McMillan, Carlos Martinez-Fleites, John Porter, David Fox, Rachel Davis, Prashant Mori, Tom Ceska, Bruce Carrington, Alastair Lawson, Tim Bourne, James O’Connell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Small molecules stabilising a distorted TNF trimer can inhibit TNF signaling, but the underlying mechanism is unclear. Here, the authors characterize the inhibitor-bound TNF-receptor complex structurally and biochemically, showing that the inhibitors
Externí odkaz:
https://doaj.org/article/7b680bc50b1f4b8588a84e2e0adb588a
Autor:
James O’Connell, John Porter, Boris Kroeplien, Tim Norman, Stephen Rapecki, Rachel Davis, David McMillan, Tracy Arakaki, Alex Burgin, David Fox III, Tom Ceska, Fabien Lecomte, Alison Maloney, Alex Vugler, Bruce Carrington, Benjamin P Cossins, Tim Bourne, Alastair Lawson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
While biologics have been successfully applied in TNF antagonist treatments, there are no clinically approved small molecules that target TNF. Here, the authors discover potent small molecule inhibitors of TNF, elucidate their molecular mechanism, an
Externí odkaz:
https://doaj.org/article/cd8aea08c83948d3a69fc5302494dedc
Autor:
Tim Bourne, Prashant Mori, Rachel Davis, Tom Ceska, Alastair D. G. Lawson, O'connell James Philip, Bruce Carrington, John Robert Porter, David A. Fox, Carlos Martinez-Fleites, David McMillan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Tumour necrosis factor (TNF) is a trimeric protein which signals through two membrane receptors, TNFR1 and TNFR2. Previously, we identified small molecules that inhibit human TNF by stabilising a distorted trimer and reduce the number of receptors bo
Autor:
Bruce Carrington, Geoffrey Short
Publikováno v:
Children and their Primary Schools ISBN: 9781315863672
Children and their Primary Schools
Children and their Primary Schools
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bc14014e39c137b8b2886b75814ea1f
https://doi.org/10.4324/9781315863672-15
https://doi.org/10.4324/9781315863672-15
Autor:
Alison Maloney, John Robert Porter, O'connell James Philip, Bruce Carrington, Alison Turner, David A. Fox, Tom Ceska, David McMillan, Anthony Scott-Tucker, Antje Schmidt, Daniel John Lightwood, Tim Bourne, Rebecca Munro, Alastair D. G. Lawson, Elizabeth S. Hickford
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications
Nature Communications
We have recently described the development of a series of small-molecule inhibitors of human tumour necrosis factor (TNF) that stabilise an open, asymmetric, signalling-deficient form of the soluble TNF trimer. Here, we describe the generation, chara
Autor:
Jean M. H. van den Elsen, Bruce Carrington, Neesha Dedi, Xiaofeng Liu, Alastair D. G. Lawson, Sam Heywood, Jeffery Kennedy, Alex Macpherson, Oliver Durrant
Publikováno v:
The Journal of Biological Chemistry
Macpherson, A, Liu, X, Dedi, N, Kennedy, J, Carrington, B, Durrant, O, Heywood, S, van den Elsen, J & Lawson, A D G 2018, ' The rational design of affinity attenuated OmCI for the purification of Complement C5 ', The Journal of biological chemistry, vol. 293, no. 36, pp. 14112-14121 . https://doi.org/10.1074/jbc.RA118.004043
Macpherson, A, Liu, X, Dedi, N, Kennedy, J, Carrington, B, Durrant, O, Heywood, S, van den Elsen, J & Lawson, A D G 2018, ' The rational design of affinity attenuated OmCI for the purification of Complement C5 ', The Journal of biological chemistry, vol. 293, no. 36, pp. 14112-14121 . https://doi.org/10.1074/jbc.RA118.004043
Complement component C5 is the target of the monoclonal antibody Eculizumab, and the focus of a sustained drug discovery effort to prevent complement-induced inflammation in a range of autoimmune diseases. The immune evasion protein OmCI binds to, an
Autor:
David A. Fox, Bruce Carrington, Rachel Davis, Alex Vugler, John Robert Porter, Timothy John Norman, Benjamin P. Cossins, Boris Kroeplien, Fabien Claude Lecomte, David McMillan, Alastair D. G. Lawson, Alex B. Burgin, Tim Bourne, Stephen Edward Rapecki, Tom Ceska, O'connell James Philip, Alison Maloney, Tracy Arakaki
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Tumour necrosis factor (TNF) is a cytokine belonging to a family of trimeric proteins; it has been shown to be a key mediator in autoimmune diseases such as rheumatoid arthritis and Crohn’s disease. While TNF is the target of several successful bio
Autor:
Bruce Carrington, Edward Wood
Publikováno v:
The Caribbean in Europe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96d933c4a13bc9452375247d0816bec7
https://doi.org/10.4324/9781315035079-11
https://doi.org/10.4324/9781315035079-11