Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Bruce, NG"'
Autor:
Bruce Ng, Tanesha Cash-Mason, Yi Wang, Jessica Seitzer, Julja Burchard, Duncan Brown, Vadim Dudkin, Joseph Davide, Vasant Jadhav, Laura Sepp-Lorenzino, Pedro J. Cejas
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 16, Iss , Pp 194-205 (2019)
Clinical application of siRNA-based therapeutics outside of the liver has been hindered by the inefficient delivery of siRNA effector molecules into extra-hepatic organs and cells of interest. To understand the parameters that enable RNAi activity in
Externí odkaz:
https://doaj.org/article/6ad8ee93c61c45c1a058a2bb051c2398
Proof-of-concept Studies for siRNA-mediated Gene Silencing for Coagulation Factors in Rat and Rabbit
Autor:
Zhu Chen, Bin Luo, Tian-Quan Cai, Anil Thankappan, Yiming Xu, Weizhen Wu, Jillian DiMuzio, Traci Lifsted, Marty DiPietro, Jyoti Disa, Bruce Ng, Karen Leander, Seth Clark, Lizbeth Hoos, Yuchen Zhou, Nina Jochnowitz, Christine Jachec, Peter Szczerba, Marian E Gindy, Walter Strapps, Laura Sepp-Lorenzino, Dietmar A Seiffert, Laura Lubbers, Marija Tadin-Strapps
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)
The present study aimed at establishing feasibility of delivering short interfering RNA (siRNA) to target the coagulation cascade in rat and rabbit, two commonly used species for studying thrombosis and hemostasis. siRNAs that produced over 90% mRNA
Externí odkaz:
https://doaj.org/article/da51b10ff9c64e0ebedcb655dbab5e3c
Autor:
Ute Frevert, Sabine Engelmann, Sergine Zougbédé, Jörg Stange, Bruce Ng, Kai Matuschewski, Leonard Liebes, Herman Yee
Publikováno v:
PLoS Biology, Vol 3, Iss 6, p e192 (2005)
Plasmodium sporozoite invasion of liver cells has been an extremely elusive event to study. In the prevailing model, sporozoites enter the liver by passing through Kupffer cells, but this model was based solely on incidental observations in fixed spe
Externí odkaz:
https://doaj.org/article/4c44ca39fc3e405a80a2de4aeb57510f
Autor:
Wang, H, Liddell, CA, Coates, MM, Mooney, MD, Levitz, CE, Schumacher, AE, Apfel, H, Iannarone, M, Phillips, B, Lofgren, KT, Sandar, L, Dorrington, RE, Rakovac, I, Jacobs, TA, Liang, X, Zhou, M, Zhu, J, Yang, G, Wang, Y, Liu, S, Li, Y, Ozgoren, AA, Abera, SF, Abubakar, I, Achoki, T, Adelekan, A, Ademi, Z, Alemu, ZA, Allen, PJ, AlMazroa, MA, Alvarez, E, Amankwaa, AA, Amare, AT, Ammar, W, Anwari, P, Cunningham, SA, Asad, MM, Assadi, R, Banerjee, A, Basu, S, Bedi, N, Bekele, T, Bell, ML, Bhutta, Z, Blore, JD, Basara, BB, Boufous, S, Breitborde, N, Bruce, NG, Bui, LN, Carapetis, JR, Cárdenas, R, Carpenter, DO, Caso, V, Castro, RE, Catalá-Lopéz, F, Cavlin, A, Che, X, Chiang, PP, Chowdhury, R, Christophi, CA, Chuang, TW, Cirillo, M, da Costa Leite, I, Courville, KJ, Dandona, L, Dandona, R, Davis, A, Dayama, A, Deribe, K, Dharmaratne, SD, Dherani, MK, Dilmen, U, Ding, EL, Edmond, KM, Ermakov, SP, Farzadfar, F, Fereshtehnejad, SM, Fijabi, DO, Foigt, N, Forouzanfar, MH, Garcia, AC, Geleijnse, JM, Gessner, BD, Goginashvili, K, Gona, P, Goto, A, Gouda, HN, Green, MA, Greenwell, KF, Gugnani, HC, Gupta, R, Hamadeh, RR, Hammami, M, Harb, HL, Hay, Simon, Hedayati, MT, Hosgood, HD, Hoy, DG, Idrisov, BT, Islami, F, Ismayilova, S, Jha, Vivekanand, Jiang, G, Jonas, JB, Juel, K, Kabagambe, EK, Kazi, DS, Kengne, AP, Kereselidze, M, Khader, YS, Khalifa, SE, Khang, YH, Kim, D, Kinfu, Y, Kinge, JM, Kokubo, Y, Kosen, S, Defo, BK, Kumar, GA, Kumar, K, Kumar, RB, Lai, T, Lan, Q, Larsson, A, Lee, JT, Leinsalu, M, Lim, SS, Lipshultz, SE, Logroscino, G, Lotufo, PA, Lunevicius, R, Lyons, RA, Ma, S, Mahdi, AA, Marzan, MB, Mashal, MT, Mazorodze, TT, McGrath, JJ, Memish, ZA, Mendoza, W, Mensah, GA, Meretoja, A, Miller, TR, Mills, EJ, Mohammad, KA, Mokdad, AH, Monasta, L, Montico, M, Moore, AR, Moschandreas, Joanna, Msemburi, WT, Mueller, UO, Muszynska, MM, Naghavi, M, Naidoo, KS, Narayan, KM, Nejjari, C, Ng, M, de Dieu Ngirabega, J, Nieuwenhuijsen, MJ, Nyakarahuka, L, Ohkubo, T, Omer, SB, Caicedo, AJ, Pillay-van Wyk, V, Pope, D, Pourmalek, F, Prabhakaran, D, Rahman, SU, Rana, SM, Reilly, RQ, Rojas-Rueda, D, Ronfani, L, Rushton, L, Saeedi, MY, Salomon, JA, Sampson, U, Santos, IS, Sawhney, M, Schmidt, JC, Shakh-Nazarova, M, She, J, Sheikhbahaei, S, Shibuya, K, Shin, HH, Shishani, K, Shiue, I, Sigfusdottir, ID, Singh, JA, Skirbekk, V, Sliwa, K, Soshnikov, SS, Sposato, LA, Stathopoulou, VK, Stroumpoulis, K, Tabb, KM, Talongwa, RT, Teixeira, CM, Terkawi, AS, Thomson, AJ, Thorne-Lyman, AL, Toyoshima, H, Dimbuene, ZT, Uwaliraye, P, Uzun, SB, Vasankari, TJ, Vasconcelos, AM, Vlassov, VV, Vollset, SE, Waller, S, Wan, X, Weichenthal, S, Weiderpass, E, Weintraub, RG, Westerman, R, Wilkinson, JD, Williams, HC, Yang, YC, Yentur, GK, Yip, P, Yonemoto, N, Younis, M, Yu, C, Jin, KY, El Sayed Zaki, M, Zhu, S, Vos, T, Lopez, AD, Murray, CJ
Remarkable financial and political efforts have been focused on the reduction of child mortality during the past few decades. Timely measurements of levels and trends in under-5 mortality are important to assess progress towards the Millennium Develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d1c1082405691cf912a22ebc72b64c14
https://doi.org/10.1016/s0140-6736(14)60497-9
https://doi.org/10.1016/s0140-6736(14)60497-9
Autor:
Andrea Matter, Laura Sepp-Lorenzino, Guo-Jun Zhang, Ye Zhang, South Victoria J, Bruce Ng, Weikang Tao, Joseph P. Davide, Mingmei Cai
Publikováno v:
Molecular Therapy. 18:1657-1666
Mouse models with liver-specific expression of firefly luciferase were developed that enable a noninvasive and longitudinal assessment of small-interfering RNA (siRNA)–mediated gene silencing in hepatocytes of live animals via bioluminescence imagi
Autor:
Bruce Ng, Madhu Mazumdar, Leonard Liebes, Dean F. Bajorin, Iman Osman, Anna C. Pavlick, David Polsky, Richard L. Shapiro, Peter C. Brooks, Russell S. Berman, Anthony M.P. Montgomery, Melanie Warycha, Jan Zakrzewski, Paul J. Christos
Publikováno v:
Clinical Cancer Research. 14:6253-6258
Purpose: Extracellular matrix remodeling during tumor growth plays an important role in angiogenesis. Our preclinical data suggest that a newly identified cryptic epitope (HU177) within collagen type IV regulates endothelial and melanoma cell adhesio
Autor:
Balmes, John, Pope, D, Diaz, E, Smith-Sivertsen, T, Lie, RT, Bakke, P, Balmes, JR, Smith, KR, Bruce, NG
Publikováno v:
Balmes, John; Pope, D; Diaz, E; Smith-Sivertsen, T; Lie, RT; Bakke, P; et al.(2015). Exposure to household air pollution from wood combustion and association with respiratory symptoms and lung function in nonsmoking women: Results from the RESPIRE trial, Guatemala. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/6bv9z0v0
© 2015 Public Health Services, US Dept of Health and Human Services. All rights reserved.Background: With 40% of the world’s population relying on solid fuel, household air pollution (HAP) represents a major preventable risk factor for COPD (chron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::6ab33c2d4afa95d2642c1ea731b070d3
http://www.escholarship.org/uc/item/6bv9z0v0
http://www.escholarship.org/uc/item/6bv9z0v0
Autor:
Leonard Liebes, Peter C. Brooks, Bruce Ng, Shannon M. MacDonald, Jennifer M. Roth, Silvia C. Formenti, Desiree Policarpio, Anat Zelmanovich, Abebe Akalu
Publikováno v:
The American Journal of Pathology. 166:901-911
Cellular interaction with the extracellular matrix is thought to be a critical event in controlling angiogenesis and tumor growth. In our previous studies, genetically distinct noncollagenous (NC) domains of type-IV collagen were shown to interact wi
Autor:
Silvia C. Formenti, Sandra Demaria, Leonard Liebes, Bruce Ng, James S. Babb, Noriko Kawashima, M. Devitt
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 58:862-870
Purpose Ionizing radiation can reduce tumor growth outside the field of radiation, known as the abscopal effect. Although it has been reported in multiple malignancies, the abscopal effect remains a rare and poorly understood event. Ionizing radiatio
Proof-of-concept Studies for siRNA-mediated Gene Silencing for Coagulation Factors in Rat and Rabbit
Autor:
Laura Sepp-Lorenzino, Anil Thankappan, Yuchen Zhou, Traci Q. Lifsted, Jillian DiMuzio, Karen R. Leander, Marija Tadin-Strapps, Laura S. Lubbers, Lizbeth Hoos, Zhu Chen, Bruce Ng, Peter Szczerba, Marian E. Gindy, Seth Clark, Weizhen Wu, Bin Luo, Nina Jochnowitz, Dietmar Seiffert, Jyoti Disa, Tian-Quan Cai, Marty DiPietro, Yiming Xu, Walter Strapps, Christine Jachec
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)
Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)
The present study aimed at establishing feasibility of delivering short interfering RNA (siRNA) to target the coagulation cascade in rat and rabbit, two commonly used species for studying thrombosis and hemostasis. siRNAs that produced over 90% mRNA