Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Brubaker JD"'
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Davis AJ; Blueprint Medicines Corporation, Cambridge, MA 02139, USA., Brooijmans N; Blueprint Medicines Corporation, Cambridge, MA 02139, USA., Brubaker JD; Blueprint Medicines Corporation, Cambridge, MA 02139, USA., Stevison F; Blueprint Medicines Corporation, Cambridge, MA 02139, USA., LaBranche TP; Blueprint Medicines Corporation, Cambridge, MA 02139, USA., Albayya F; Blueprint Medicines Corporation, Cambridge, MA 02139, USA., Fleming P; Blueprint Medicines Corporation, Cambridge, MA 02139, USA., Hodous BL; Blueprint Medicines Corporation, Cambridge, MA 02139, USA., Kim JL; Blueprint Medicines Corporation, Cambridge, MA 02139, USA., Kim S; Blueprint Medicines Corporation, Cambridge, MA 02139, USA., Lobbardi R; Blueprint Medicines Corporation, Cambridge, MA 02139, USA., Palmer M; Blueprint Medicines Corporation, Cambridge, MA 02139, USA., Sheets MP; Blueprint Medicines Corporation, Cambridge, MA 02139, USA., Vassiliadis J; Blueprint Medicines Corporation, Cambridge, MA 02139, USA., Wang R; Blueprint Medicines Corporation, Cambridge, MA 02139, USA., Williams BD; Blueprint Medicines Corporation, Cambridge, MA 02139, USA., Wilson D; Blueprint Medicines Corporation, Cambridge, MA 02139, USA., Xu L; Blueprint Medicines Corporation, Cambridge, MA 02139, USA., Zhu XJ; Blueprint Medicines Corporation, Cambridge, MA 02139, USA., Bouchard K; Alexion Pharmaceuticals, Boston, MA 02210, USA., Hunter JW; Alexion Pharmaceuticals, Boston, MA 02210, USA., Graul C; Invicro, Boston, MA 02210, USA., Greenblatt E; Invicro, Boston, MA 02210, USA., Hussein A; Invicro, Boston, MA 02210, USA., Lyon M; Invicro, Boston, MA 02210, USA., Russo J; Invicro, Boston, MA 02210, USA., Stewart R; Invicro, Boston, MA 02210, USA., Dorsch M; Blueprint Medicines Corporation, Cambridge, MA 02139, USA., Guzi TJ; Blueprint Medicines Corporation, Cambridge, MA 02139, USA., Kadambi V; Blueprint Medicines Corporation, Cambridge, MA 02139, USA., Lengauer C; Blueprint Medicines Corporation, Cambridge, MA 02139, USA., Garner AP; Blueprint Medicines Corporation, Cambridge, MA 02139, USA.
Publikováno v:
Science translational medicine [Sci Transl Med] 2024 May 29; Vol. 16 (749), pp. eabp8334. Date of Electronic Publication: 2024 May 29.
Autor:
Eno MS; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Brubaker JD; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Campbell JE; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., De Savi C; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Guzi TJ; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Williams BD; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Wilson D; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Wilson K; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Brooijmans N; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Kim J; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Özen A; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Perola E; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Hsieh J; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Brown V; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Fetalvero K; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Garner A; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Zhang Z; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Stevison F; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Woessner R; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Singh J; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Timsit Y; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Kinkema C; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Medendorp C; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Lee C; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Albayya F; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Zalutskaya A; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Schalm S; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States., Dineen TA; Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2022 Jul 28; Vol. 65 (14), pp. 9662-9677. Date of Electronic Publication: 2022 Jul 15.
Autor:
Subbiah V; Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Gainor JF; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts., Rahal R; Blueprint Medicines Corporation, Cambridge, Massachusetts., Brubaker JD; Blueprint Medicines Corporation, Cambridge, Massachusetts., Kim JL; Blueprint Medicines Corporation, Cambridge, Massachusetts., Maynard M; Blueprint Medicines Corporation, Cambridge, Massachusetts., Hu W; Blueprint Medicines Corporation, Cambridge, Massachusetts., Cao Q; Blueprint Medicines Corporation, Cambridge, Massachusetts., Sheets MP; Blueprint Medicines Corporation, Cambridge, Massachusetts., Wilson D; Blueprint Medicines Corporation, Cambridge, Massachusetts., Wilson KJ; Blueprint Medicines Corporation, Cambridge, Massachusetts., DiPietro L; Blueprint Medicines Corporation, Cambridge, Massachusetts., Fleming P; Blueprint Medicines Corporation, Cambridge, Massachusetts., Palmer M; Blueprint Medicines Corporation, Cambridge, Massachusetts., Hu MI; Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, Texas., Wirth L; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts., Brose MS; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania., Ou SI; Chao Family Comprehensive Cancer Center, University of California Irvine Medical Center, Irvine, California., Taylor M; The Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Garralda E; Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Miller S; Blueprint Medicines Corporation, Cambridge, Massachusetts., Wolf B; Blueprint Medicines Corporation, Cambridge, Massachusetts., Lengauer C; Blueprint Medicines Corporation, Cambridge, Massachusetts., Guzi T; Blueprint Medicines Corporation, Cambridge, Massachusetts., Evans EK; Blueprint Medicines Corporation, Cambridge, Massachusetts. eevans@blueprintmedicines.com.
Publikováno v:
Cancer discovery [Cancer Discov] 2018 Jul; Vol. 8 (7), pp. 836-849. Date of Electronic Publication: 2018 Apr 15.
Autor:
Smith GF; AstraZeneca, 35 Gatehouse Drive, Waltham, MA 02451, United States. Electronic address: Graham.smith@astrazeneca.com., Altman MD; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Andresen B; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Baker J; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Brubaker JD; Blueprint Medicines, 38 Sidney St Suite 200, Cambridge, MA 02139, United States., Chen H; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Chen Y; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Childers M; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Donofrio A; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Ferguson H; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Fischer C; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Fischmann TO; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Gibeau C; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Hicks A; Oncorus, 50 Hampshire St. Suite 401, Cambridge, MA 02139, United States., Jin S; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Kattar S; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Kleinschek MA; Theravance Biopharma US, Inc., 901 Gateway Boulevard, South San Francisco, CA 94080, United States., Leccese E; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Lesburg C; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Li C; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Lim J; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States. Electronic address: jongwon_lim@merck.com., Liu D; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Maclean JKF; Redx Pharma, Block 33, Mereside, Alderley Park, Macclesfield SK10 4TG, United Kingdom., Mansoor F; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Moy LY; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Mulrooney EF; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Necheva AS; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Presland J; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Rakhilina L; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Yang R; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Torres L; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Zhang-Hoover J; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Northrup A; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, United States.
Publikováno v:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Jun 15; Vol. 27 (12), pp. 2721-2726. Date of Electronic Publication: 2017 Apr 18.
Autor:
Lim J; Department of Chemistry, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, United States. Electronic address: jongwon_lim@merck.com., Altman MD; Department of Chemistry Modeling and Informatics, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Baker J; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Brubaker JD; Department of Chemistry, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Chen H; Department of In Vitro Pharmacology, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Chen Y; Department of In Vitro Pharmacology, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Kleinschek MA; Department of Immunology, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Li C; Department of Chemistry, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Liu D; Department of Chemistry, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Maclean JK; Department of Chemistry Modeling and Informatics, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Mulrooney EF; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Presland J; Department of In Vitro Pharmacology, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Rakhilina L; Department of In Vitro Pharmacology, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Smith GF; Department of Chemistry, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, United States., Yang R; Department of In Vitro Pharmacology, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, United States.
Publikováno v:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Nov 15; Vol. 25 (22), pp. 5384-8. Date of Electronic Publication: 2015 Sep 11.
Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4.
Autor:
Lim J; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, Drug Metabolism and Pharmacokinetics, In Vitro Pharmacology, In Vivo Pharmacology, and Structural Chemistry, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Altman MD; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, Drug Metabolism and Pharmacokinetics, In Vitro Pharmacology, In Vivo Pharmacology, and Structural Chemistry, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Baker J; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, Drug Metabolism and Pharmacokinetics, In Vitro Pharmacology, In Vivo Pharmacology, and Structural Chemistry, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Brubaker JD; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, Drug Metabolism and Pharmacokinetics, In Vitro Pharmacology, In Vivo Pharmacology, and Structural Chemistry, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Chen H; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, Drug Metabolism and Pharmacokinetics, In Vitro Pharmacology, In Vivo Pharmacology, and Structural Chemistry, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Chen Y; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, Drug Metabolism and Pharmacokinetics, In Vitro Pharmacology, In Vivo Pharmacology, and Structural Chemistry, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Fischmann T; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, Drug Metabolism and Pharmacokinetics, In Vitro Pharmacology, In Vivo Pharmacology, and Structural Chemistry, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Gibeau C; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, Drug Metabolism and Pharmacokinetics, In Vitro Pharmacology, In Vivo Pharmacology, and Structural Chemistry, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Kleinschek MA; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, Drug Metabolism and Pharmacokinetics, In Vitro Pharmacology, In Vivo Pharmacology, and Structural Chemistry, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Leccese E; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, Drug Metabolism and Pharmacokinetics, In Vitro Pharmacology, In Vivo Pharmacology, and Structural Chemistry, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Lesburg C; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, Drug Metabolism and Pharmacokinetics, In Vitro Pharmacology, In Vivo Pharmacology, and Structural Chemistry, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Maclean JK; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, Drug Metabolism and Pharmacokinetics, In Vitro Pharmacology, In Vivo Pharmacology, and Structural Chemistry, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Moy LY; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, Drug Metabolism and Pharmacokinetics, In Vitro Pharmacology, In Vivo Pharmacology, and Structural Chemistry, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Mulrooney EF; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, Drug Metabolism and Pharmacokinetics, In Vitro Pharmacology, In Vivo Pharmacology, and Structural Chemistry, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Presland J; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, Drug Metabolism and Pharmacokinetics, In Vitro Pharmacology, In Vivo Pharmacology, and Structural Chemistry, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Rakhilina L; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, Drug Metabolism and Pharmacokinetics, In Vitro Pharmacology, In Vivo Pharmacology, and Structural Chemistry, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Smith GF; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, Drug Metabolism and Pharmacokinetics, In Vitro Pharmacology, In Vivo Pharmacology, and Structural Chemistry, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Steinhuebel D; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, Drug Metabolism and Pharmacokinetics, In Vitro Pharmacology, In Vivo Pharmacology, and Structural Chemistry, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Yang R; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, Drug Metabolism and Pharmacokinetics, In Vitro Pharmacology, In Vivo Pharmacology, and Structural Chemistry, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
Publikováno v:
ACS medicinal chemistry letters [ACS Med Chem Lett] 2015 Apr 20; Vol. 6 (6), pp. 683-8. Date of Electronic Publication: 2015 Apr 20 (Print Publication: 2015).
Autor:
Hamzik PJ; Department of Chemistry, Merck and Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA., Brubaker JD
Publikováno v:
Organic letters [Org Lett] 2010 Mar 05; Vol. 12 (5), pp. 1116-9.