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Inhibition of GCK-IV kinases dissociates cell death and axon regeneration in CNS neurons

Autor: Patel, Amit K, Broyer, Risa M, Lee, Cassidy D, Lu, Tianlun, Louie, Mikaela J, La Torre, Anna, Al-Ali, Hassan, Vu, Mai T, Mitchell, Katherine L, Wahlin, Karl J, Berlinicke, Cynthia A, Jaskula-Ranga, Vinod, Hu, Yang, Duan, Xin, Vilar, Santiago, Bixby, John L, Weinreb, Robert N, Lemmon, Vance P, Zack, Donald J, Welsbie, Derek S

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 52

Axon injury is a hallmark of many neurodegenerative diseases, often resulting in neuronal cell death and functional impairment. Dual leucine zipper kinase (DLK) has emerged as a key mediator of this process. However, while DLK inhibition is robustly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7468ff36683eb68cffdd33d1f22a738f
https://escholarship.org/uc/item/46q3851f

Spatial organization of mRNA regulation and metabolic activity

Autor: Broyer, Risa Maruyama

Publikováno v: Broyer, Risa Maruyama. (2016). Spatial organization of mRNA regulation and metabolic activity. UC San Diego: Biology. Retrieved from: http://www.escholarship.org/uc/item/11t4j2p2

Organization of biological processes is a central principle of cell biology. However, until recently, the context of this organization has largely centered on membrane-bound organelles and their internal biochemistry. Recent discoveries of intracellu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::37484710edcae2e14a5782db9e3e9dea
http://www.escholarship.org/uc/item/11t4j2p2

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A quantitative screen for metabolic enzyme structures reveals patterns of assembly across the yeast metabolic network.

Autor: Noree C; Howard Hughes Medical Institute Summer Institute, Marine Biological Laboratory, Woods Hole, MA 02543.; Institute of Molecular Biosciences, Mahidol University, Phuttamonthon, Nakhon Pathom 73170, Thailand., Begovich K; Howard Hughes Medical Institute Summer Institute, Marine Biological Laboratory, Woods Hole, MA 02543.; Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093., Samilo D; Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093., Broyer R; Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093., Monfort E; Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093., Wilhelm JE; Howard Hughes Medical Institute Summer Institute, Marine Biological Laboratory, Woods Hole, MA 02543.; Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093.

Publikováno v: Molecular biology of the cell [Mol Biol Cell] 2019 Oct 01; Vol. 30 (21), pp. 2721-2736. Date of Electronic Publication: 2019 Sep 04.