Alkaline cation-exchange chromatography for the reduction of aggregate and a mis-formed disulfide variant in a bispecific antibody purification process.

Autor: Hall T; Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285-0001 USA. Electronic address: hall_troii@lilly.com., Wilson JJ; Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285-0001 USA. Electronic address: wilson_joseph_j@lilly.com., Brownlee TJ; Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285-0001 USA. Electronic address: brownlee_tammy_j@lilly.com., Swartling JR; Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285-0001 USA. Electronic address: swartling_james_r@lilly.com., Langan SE; Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285-0001 USA. Electronic address: langan_sarah_e@lilly.com., Lambooy PK; Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285-0001 USA. Electronic address: lambooy_peter_k@lilly.com.

Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2015 Jan 15; Vol. 975, pp. 1-8. Date of Electronic Publication: 2014 Nov 08.