Inter-chromosomal contacts demarcate genome topology along a spatial gradient.

Autor: Mokhtaridoost M; Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON, M5G 0A4, Canada., Chalmers JJ; Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON, M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada., Soleimanpoor M; Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON, M5G 0A4, Canada., McMurray BJ; Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON, M5G 0A4, Canada., Lato DF; Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON, M5G 0A4, Canada., Nguyen SC; Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Musienko V; Jena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Am Klinikum 1, 07747, Jena, Germany., Nash JO; Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON, M5G 0A4, Canada.; Laboratory of Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Espeso-Gil S; Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON, M5G 0A4, Canada., Ahmed S; Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON, M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada., Delfosse K; Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON, M5G 0A4, Canada., Browning JWL; Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON, M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada., Barutcu AR; Donnelly Centre, University of Toronto, Toronto, ON, M5S 3E1, Canada., Wilson MD; Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON, M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada., Liehr T; Jena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Am Klinikum 1, 07747, Jena, Germany., Shlien A; Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON, M5G 0A4, Canada.; Laboratory of Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Aref S; Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, M5S3G8, Canada., Joyce EF; Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Weise A; Jena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Am Klinikum 1, 07747, Jena, Germany., Maass PG; Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON, M5G 0A4, Canada. philipp.maass@sickkids.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada. philipp.maass@sickkids.ca.

Publikováno v: Nature communications [Nat Commun] 2024 Nov 13; Vol. 15 (1), pp. 9813. Date of Electronic Publication: 2024 Nov 13.

A noncoding single-nucleotide polymorphism at 8q24 drives IDH1 -mutant glioma formation.

Autor: Yanchus C; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Drucker KL; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Kollmeyer TM; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Tsai R; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Winick-Ng W; Max-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, 13092 Berlin, Germany., Liang M; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Malik A; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Pawling J; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., De Lorenzo SB; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Ali A; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Decker PA; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Kosel ML; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Panda A; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Al-Zahrani KN; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Jiang L; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Browning JWL; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Lowden C; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Geuenich M; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Hernandez JJ; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Gosio JT; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Ahmed M; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Loganathan SK; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Berman J; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Trcka D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Michealraj KA; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Fortin J; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada., Carson B; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Hollingsworth EW; Department of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA., Jacinto S; Department of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA., Mazrooei P; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Zhou L; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada., Elia A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada., Lupien M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada., He HH; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Murphy DJ; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1BD, Scotland, UK.; Cancer Research UK Beatson Institute, Glasgow G61 1BD, Scotland, UK., Wang L; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Abyzov A; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Dennis JW; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Maass PG; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Campbell K; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Wilson MD; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Lachance DH; Departments of Neurology and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Wrensch M; Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA., Wiencke J; Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA., Mak T; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Pennacchio LA; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94710, USA.; Comparative Biochemistry Program, University of California, Berkeley, CA 94720, USA.; US Department of Energy Joint Genome Institute, Berkeley, CA 94720, USA., Dickel DE; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94710, USA., Visel A; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94710, USA.; US Department of Energy Joint Genome Institute, Berkeley, CA 94720, USA.; School of Natural Sciences, University of California, Merced, CA 95343, USA., Wrana J; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Taylor MD; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Zadeh G; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Dirks P; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Eckel-Passow JE; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Attisano L; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.; Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada., Pombo A; Max-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, 13092 Berlin, Germany.; Institute of Biology, Humboldt University of Berlin, 10115 Berlin, Germany., Ida CM; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Kvon EZ; Department of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA., Jenkins RB; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Schramek D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.

Publikováno v: Science (New York, N.Y.) [Science] 2022 Oct 07; Vol. 378 (6615), pp. 68-78. Date of Electronic Publication: 2022 Oct 06.

Rapid Decrease in KRT14 and TP53 mRNA Expression in the Buccal Mucosa of Patients Receiving Total-Body Irradiation for Allogeneic Stem Cell Transplantation.

Autor: Chmara J; a   Department of Biology and., Browning JWL; a   Department of Biology and., Atkins H; c   Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Canada; and.; d   Ottawa Hospital Research Institute, Ottawa, Canada., Sabloff M; c   Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Canada; and.; d   Ottawa Hospital Research Institute, Ottawa, Canada., McKay BC; a   Department of Biology and.; b   Institute of Biochemistry, Carleton University, Ottawa, Canada.

Publikováno v: Radiation research [Radiat Res] 2018 Feb; Vol. 189 (2), pp. 213-218. Date of Electronic Publication: 2017 Dec 12.