Turmeric curcumin inhibits entry of all hepatitis c virus genotypres into human liver cells

Autor: Kusuma, A., Colpitts, C. C., Schang, L. M., Rachmawati, H., Frentzen, A., Pfaender, S., Behrendt, P., Brown, RJP, Bankwitz, D., Steinmann, Jörg, Ott, M., Meuleman, P., Pietschmann, T., Steinmann, E.

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MicroRNAs modulate SARS-CoV-2 infection of primary human hepatocytes by regulating the entry factors ACE2 and TMPRSS2.

Autor: Khanal R; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.; Research Group Liver Regeneration & RNA Therapeutics, REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany., Heinen N; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany., Bogomolova A; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.; Research Group Liver Regeneration & RNA Therapeutics, REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany., Meister TL; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.; Institute for Infection Research and Vaccine Development (IIRVD), Centre for Internal Medicine, University Medical Centre Hamburg-Eppendorf (UKE), Hamburg, Germany.; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany., Herrmann ST; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.; Research Unit Emerging Viruses, Leibniz Institute of Virology (LIV), Hamburg, Germany., Westhoven S; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.; Research Unit Emerging Viruses, Leibniz Institute of Virology (LIV), Hamburg, Germany., Nocke MK; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany., Todt D; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.; European Virus Bioinformatics Center (EVBC), Jena, Germany., Jockenhövel F; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany., Klein IM; Tissue Bank of the German Center for Infection Research (DZIF), Partner Site Heidelberg, Heidelberg, Germany.; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Hartmann L; Tissue Bank of the German Center for Infection Research (DZIF), Partner Site Heidelberg, Heidelberg, Germany.; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Vondran FWR; Department of General, Visceral, Pediatric and Transplant Surgery, University Hospital RWTH Aachen, Aachen, Germany., Steinmann E; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany., Zimmer G; Institute of Virology and Immunology, Bern, Switzerland.; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland., Ott M; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany., Brown RJP; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany., Sharma AD; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.; Research Group Liver Regeneration & RNA Therapeutics, REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany., Pfaender S; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.; Research Unit Emerging Viruses, Leibniz Institute of Virology (LIV), Hamburg, Germany.; University of Lübeck, Lübeck, Germany.

Publikováno v: Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2024 Nov; Vol. 44 (11), pp. 2983-2995. Date of Electronic Publication: 2024 Aug 22.

Productive infection of primary human hepatocytes with SARS-CoV-2 induces antiviral and proinflammatory responses.

Autor: Heinen N; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany., Khanal R; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.; Research Group RNA Therapeutics & Liver Regeneration, REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany, Hannover Medical School, Hannover, Germany., Westhoven S; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany., Klöhn M; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany., Herrmann ST; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany., Herrmann M; Division of Veterinary Medicine, Paul-Ehrlich-Institute, Langen, Germany., Tuoc T; Department of Human Genetics, Ruhr University Bochum, Bochum, Germany., Ulmke PA; Department of Human Genetics, Ruhr University Bochum, Bochum, Germany., Nguyen HD; Department of Human Genetics, Ruhr University Bochum, Bochum, Germany., Nguyen HP; Department of Human Genetics, Ruhr University Bochum, Bochum, Germany., Steinmann E; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.; German Centre for Infection Research (DZIF), External Partner Site, Bochum, Germany, Bochum, Germany., Todt D; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.; European Virus Bioinformatics Center (EVBC), Jena, Germany., Brown RJP; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany stephanie.pfaender@rub.de sharma.amar@mh-hannover.de richard.brown@ruhr-uni-bochum.de.; Division of Veterinary Medicine, Paul-Ehrlich-Institute, Langen, Germany., Sharma AD; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany stephanie.pfaender@rub.de sharma.amar@mh-hannover.de richard.brown@ruhr-uni-bochum.de.; Research Group RNA Therapeutics & Liver Regeneration, REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany, Hannover Medical School, Hannover, Germany., Pfaender S; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany stephanie.pfaender@rub.de sharma.amar@mh-hannover.de richard.brown@ruhr-uni-bochum.de.

Publikováno v: Gut [Gut] 2024 Sep 09; Vol. 73 (10), pp. e14. Date of Electronic Publication: 2024 Sep 09.

TMPRSS2-mediated SARS-CoV-2 uptake boosts innate immune activation, enhances cytopathology, and drives convergent virus evolution.

Autor: Qu B; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany.; European Virus Bioinformatics Center, 07743 Jena, Germany., Miskey C; Division of Medical Biotechnology, Paul-Ehrlich-Institut, 63225 Langen, Germany., Gömer A; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany., Kleinert RDV; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany., Ibanez SC; Electron Microscopy of Pathogens, Paul-Ehrlich-Institut, 63225 Langen, Germany., Eberle R; Electron Microscopy of Pathogens, Paul-Ehrlich-Institut, 63225 Langen, Germany., Ebenig A; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany., Postmus D; Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.; Institute of Virology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany., Nocke MK; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany., Herrmann M; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany., Itotia TK; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany.; Department of Physical Sciences, Chuka University, 60400 Chuka, Kenya., Herrmann ST; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany., Heinen N; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany., Höck S; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany., Hastert FD; Division of Virology, Paul-Ehrlich-Institut, 63225 Langen, Germany., von Rhein C; Division of Virology, Paul-Ehrlich-Institut, 63225 Langen, Germany., Schürmann C; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany., Li X; Department of Cardiology, Medical University Hospital, 69120 Heidelberg, Germany., van Zandbergen G; Division of Immunology, Paul-Ehrlich-Institut, 63225 Langen, Germany.; Institute for Immunology, University Medical Center of the Johannes Gutenberg University of Mainz, 55131 Mainz, Germany.; Research Center for Immunotherapy, University Medical Center, Johannes Gutenberg-University Mainz, 55131 Mainz, Germany., Widera M; Institute for Medical Virology, University Hospital Frankfurt, Goethe University Frankfurt, 60596 Frankfurt am Main, Germany., Ciesek S; Institute for Medical Virology, University Hospital Frankfurt, Goethe University Frankfurt, 60596 Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology, 60596 Frankfurt am Main, Germany.; German Center for Infection Research, 38124 Braunschweig, Germany., Schnierle BS; Division of Virology, Paul-Ehrlich-Institut, 63225 Langen, Germany., Tarr AW; School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham NG7 2UH, United Kingdom.; School of Life Sciences and National Institute for Health and Care Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom., Steinmann E; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany., Goffinet C; Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.; Institute of Virology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany., Pfaender S; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany.; Research Unit Emerging Viruses, Leibniz Institute of Virology, 20251 Hamburg, Germany.; University of Lübeck, 23562 Lübeck, Germany., Locker JK; Electron Microscopy of Pathogens, Paul-Ehrlich-Institut, 63225 Langen, Germany.; Justus Liebig University Geissen, 35390 Giessen, Germany., Mühlebach MD; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany.; German Center for Infection Research, 63225 Giessen-Marburg-Langen, Germany., Todt D; European Virus Bioinformatics Center, 07743 Jena, Germany.; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany., Brown RJP; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany.; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jun 04; Vol. 121 (23), pp. e2407437121. Date of Electronic Publication: 2024 May 30.