Deep behavioural phenotyping reveals divergent trajectories of ageing and quantifies health state inC. elegans

Autor: Renée I. Seinstra, Baskaner B, Patrick Laurent, Nollen Eaa, William R Schafer, Brown Aex, Celine N. Martineau

Neurodegenerative diseases may be the cause or the consequence of an acceleration of physiological ageing. Evidence for this concept is lacking due to practical limitations of human studies. Here, we compared the processes of physiological and pathol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2369c71c9172b2c358d42aba5a0118c
https://doi.org/10.1101/555847

Collective feeding in C-elegans

Autor: Schumacher, LJ, Ding, S, Brown, AEX, Endres, RG

Publikováno v: 19th IUPAB Congress / 11th EBSA Congress
S74

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::2a9b0c6a8952483d0ed207ffedca897f
http://hdl.handle.net/10044/1/68780

Rebalancing the motor circuit restores movement in a Caenorhabditis elegans model for TDP-43 toxicity.

Autor: Koopman M; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Güngördü L; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Janssen L; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Seinstra RI; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Richmond JE; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA., Okerlund N; Howard Hughes Medical Institute and School of Biological Science, The University of Utah, Salt Lake City, UT, USA., Wardenaar R; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Islam P; MRC London Institute of Medical Sciences, London, UK; Institute of Clinical Sciences, Imperial College London, London, UK., Hogewerf W; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Brown AEX; MRC London Institute of Medical Sciences, London, UK; Institute of Clinical Sciences, Imperial College London, London, UK., Jorgensen EM; Howard Hughes Medical Institute and School of Biological Science, The University of Utah, Salt Lake City, UT, USA., Nollen EAA; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Electronic address: e.a.a.nollen@umcg.nl.

Publikováno v: Cell reports [Cell Rep] 2024 May 28; Vol. 43 (5), pp. 114204. Date of Electronic Publication: 2024 May 14.

Brain monoamine vesicular transport disease caused by homozygous SLC18A2 variants: A study in 42 affected individuals.

Autor: Saida K; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Maroofian R; Department of Neuromuscular Disorders, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom., Sengoku T; Department of Biochemistry, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Mitani T; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX., Pagnamenta AT; NIHR Oxford Biomedical Research Centre, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Marafi D; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; Department of Pediatrics, Faculty of Medicine, Kuwait University, Safat, Kuwait., Zaki MS; Department of Clinical Genetics, Human Genetics and Genome Research Institute, National Research Centre, Cairo, Egypt., O'Brien TJ; MRC London Institute of Medical Sciences, London, United Kingdom; Faculty of Medicine, Institute of Clinical Sciences, Imperial College London, London, United Kingdom., Karimiani EG; Molecular and Clinical Sciences Research Institute, St. George's, University of London, London, United Kingdom; Innovative Medical Research Center, Mashhad Branch, Islamic Azad University, Mashhad, Iran., Kaiyrzhanov R; Department of Neuromuscular Disorders, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom., Takizawa M; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Ohori S; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Leong HY; Genetics Department, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia., Akay G; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX., Galehdari H; Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran., Zamani M; Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran., Romy R; Molecular and Clinical Sciences Research Institute, St. George's, University of London, London, United Kingdom., Carroll CJ; Molecular and Clinical Sciences Research Institute, St. George's, University of London, London, United Kingdom., Toosi MB; Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Ashrafzadeh F; Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Imannezhad S; Department of Pediatric Neurology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Malek H; Department of Medical Genetics, Next Generation Genetic Polyclinic, Mashhad, Iran., Ahangari N; Department of Medical Genetics, Next Generation Genetic Polyclinic, Mashhad, Iran., Tomoum H; Department of Pediatrics, Ain Shams University, Cairo, Egypt., Gowda VK; Department of Pediatric Neurology, Indira Gandhi Institute of Child Health, Bangalore, India., Srinivasan VM; Department of Pediatric Neurology, Indira Gandhi Institute of Child Health, Bangalore, India., Murphy D; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom., Dominik N; Department of Neuromuscular Disorders, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom., Elbendary HM; Department of Clinical Genetics, Human Genetics and Genome Research Institute, National Research Centre, Cairo, Egypt., Rafat K; Department of Clinical Genetics, Human Genetics and Genome Research Institute, National Research Centre, Cairo, Egypt., Yilmaz S; Division of Pediatric Neurology, Department of Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey., Kanmaz S; Division of Pediatric Neurology, Department of Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey., Serin M; Division of Pediatric Neurology, Department of Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey., Krishnakumar D; North West Thames Regional Genetics Service, Northwick Park Hospital, London, United Kingdom., Gardham A; North West Thames Regional Genetics Service, Northwick Park Hospital, London, United Kingdom., Maw A; Department of Paediatric Neurology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom., Rao TS; Department of Paediatrics, Luton and Dunstable University Hospital, Luton, United Kingdom., Alsubhi S; Division of Pediatric Neurology, Departments of Pediatrics, McGill University, Montreal, Quebec, Canada., Srour M; Division of Pediatric Neurology, Departments of Pediatrics, McGill University, Montreal, Quebec, Canada; Research Institute of the McGill University Health Center (MUHC), Montreal, Quebec, Canada., Buhas D; Division of Medical Genetics, Department of Specialized Medicine, McGill University Health Center (MUHC), Montreal, Quebec, Canada; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Jewett T; Department of Pediatrics, Section on Medical Genetics, Wake Forest University School of Medicine, Winston-Salem, NC., Goldberg RE; Department of Pediatrics, Section on Medical Genetics, Wake Forest University School of Medicine, Winston-Salem, NC., Shamseldin H; Department of Translational Genomics, Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia., Frengen E; Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway., Misceo D; Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway., Strømme P; Division of Pediatric and Adolescent Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway., Magliocco Ceroni JR; Genetic Unit, Instituto da Crianca, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil., Kim CA; Genetic Unit, Instituto da Crianca, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil., Yesil G; Department of Medical Genetics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey., Sengenc E; Department of Pediatric Neurology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey., Guler S; Department of Child Neurology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey., Hull M; Texas Children's Hospital, Houston, TX., Parnes M; Texas Children's Hospital, Houston, TX., Aktas D; Damagen Genetic Diagnostic Center, Ankara, Turkey., Anlar B; Department of Pediatric Neurology, Hacettepe University Faculty of Medicine, Ankara, Turkey., Bayram Y; Division of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Pehlivan D; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; Texas Children's Hospital, Houston, TX; Division of Pediatric Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Houston, TX., Posey JE; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX., Alavi S; Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran., Madani Manshadi SA; Meybod Genetic Research Center, Meybod, Yazd, Iran., Alzaidan H; Department of Medical Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia., Al-Owain M; Department of Medical Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia., Alabdi L; Department of Translational Genomics, Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia., Abdulwahab F; Department of Translational Genomics, Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia., Sekiguchi F; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Hamanaka K; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Fujita A; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Uchiyama Y; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan; Department of Rare Disease Genomics, Yokohama City University Hospital, Yokohama, Japan., Mizuguchi T; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Miyatake S; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan; Clinical Genetics Department, Yokohama City University Hospital, Yokohama, Japan., Miyake N; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan; Department of Human Genetics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Elshafie RM; Kuwait Medical Genetic Centre, Ministry of Health, Kuwait., Salayev K; Department of Neurology, Azerbaijan Medical University, Baku, Azerbaijan., Guliyeva U; MediClub Hospital, Baku, Azerbaijan., Alkuraya FS; Department of Translational Genomics, Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Department of Anatomy and Cell Biology, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Gleeson JG; Department of Neurosciences, University of California San Diego, San Diego, CA; Rady Children's Institute for Genomic Medicine, San Diego, CA., Monaghan KG; GeneDx, Gaithersburg, MD., Langley KG; GeneDx, Gaithersburg, MD., Yang H; GeneDx, Gaithersburg, MD., Motavaf M; Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Safari S; Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Alipour M; Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran., Ogata K; Department of Biochemistry, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Brown AEX; MRC London Institute of Medical Sciences, London, United Kingdom; Faculty of Medicine, Institute of Clinical Sciences, Imperial College London, London, United Kingdom., Lupski JR; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; Texas Children's Hospital, Houston, TX; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX; Department of Pediatrics, Baylor College of Medicine, Houston, TX., Houlden H; Department of Neuromuscular Disorders, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom., Matsumoto N; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan. Electronic address: naomat@yokohama-cu.ac.jp.

Publikováno v: Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2023 Jan; Vol. 25 (1), pp. 90-102. Date of Electronic Publication: 2022 Oct 31.

Megapixel camera arrays enable high-resolution animal tracking in multiwell plates.

Autor: Barlow IL; Institute of Clinical Sciences, Imperial College London, London, UK.; MRC London Institute of Medical Sciences, London, UK., Feriani L; Institute of Clinical Sciences, Imperial College London, London, UK.; MRC London Institute of Medical Sciences, London, UK., Minga E; Institute of Clinical Sciences, Imperial College London, London, UK.; MRC London Institute of Medical Sciences, London, UK., McDermott-Rouse A; Institute of Clinical Sciences, Imperial College London, London, UK.; MRC London Institute of Medical Sciences, London, UK., O'Brien TJ; Institute of Clinical Sciences, Imperial College London, London, UK.; MRC London Institute of Medical Sciences, London, UK., Liu Z; Institute of Clinical Sciences, Imperial College London, London, UK.; MRC London Institute of Medical Sciences, London, UK.; Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden., Hofbauer M; Loopbio GmbH, Vienna, Austria., Stowers JR; Loopbio GmbH, Vienna, Austria., Andersen EC; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA., Ding SS; Institute of Clinical Sciences, Imperial College London, London, UK.; MRC London Institute of Medical Sciences, London, UK.; Max Planck Institute of Animal Behavior, Konstanz, Germany., Brown AEX; Institute of Clinical Sciences, Imperial College London, London, UK. andre.brown@imperial.ac.uk.; MRC London Institute of Medical Sciences, London, UK. andre.brown@imperial.ac.uk.

Publikováno v: Communications biology [Commun Biol] 2022 Mar 23; Vol. 5 (1), pp. 253. Date of Electronic Publication: 2022 Mar 23.