Heparan Sulfate Synthesized by Ext1 Regulates Receptor Tyrosine Kinase Signaling and Promotes Resistance to EGFR Inhibitors in GBM

Autor: Ohkawa, Yuki, Wade, Anna, Lindberg, Olle R, Chen, Katharine Y, Tran, Vy M, Brown, Spencer J, Kumar, Anupam, Kalita, Mausam, James, C David, Phillips, Joanna J

Publikováno v: Molecular cancer research : MCR, vol 19, iss 1

Signaling from multiple receptor tyrosine kinases (RTK) contributes to therapeutic resistance in glioblastoma (GBM). Heparan sulfate (HS), present on cell surfaces and in the extracellular matrix, regulates cell signaling via several mechanisms. To i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::2f92febf9115d87d43f625a0c3b67665
https://escholarship.org/uc/item/7936z38n

Heparan Sulfate Synthesized by Ext1 Regulates Receptor Tyrosine Kinase Signaling and Promotes Resistance to EGFR Inhibitors in GBM.

Autor: Ohkawa Y; Department of Neurological Surgery, Brain Tumor Center, University of California, San Francisco, San Francisco, California., Wade A; Department of Neurological Surgery, Brain Tumor Center, University of California, San Francisco, San Francisco, California., Lindberg OR; Department of Neurological Surgery, Brain Tumor Center, University of California, San Francisco, San Francisco, California., Chen KY; Department of Neurological Surgery, Brain Tumor Center, University of California, San Francisco, San Francisco, California., Tran VM; Department of Neurological Surgery, Brain Tumor Center, University of California, San Francisco, San Francisco, California., Brown SJ; Departments of Bioengineering and Medicinal Chemistry, University of Utah, Salt Lake City, Utah., Kumar A; Department of Neurological Surgery, Brain Tumor Center, University of California, San Francisco, San Francisco, California., Kalita M; Department of Neurological Surgery, Brain Tumor Center, University of California, San Francisco, San Francisco, California., James CD; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois., Phillips JJ; Department of Neurological Surgery, Brain Tumor Center, University of California, San Francisco, San Francisco, California. Joanna.phillips@ucsf.edu.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.; Division of Neuropathology, Department of Pathology, University of California, San Francisco, San Francisco, California.

Publikováno v: Molecular cancer research : MCR [Mol Cancer Res] 2021 Jan; Vol. 19 (1), pp. 150-161. Date of Electronic Publication: 2020 Oct 07.