A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones

Autor: Rauckhorst, Adam J. ^{1, 2, 3}, Sheldon, Ryan D. ^{1, 9}, Pape, Daniel J. ¹, Ahmed, Adnan ¹, Falls-Hubert, Kelly C. ¹, Merrill, Ronald A. ¹, Brown, Reid F. ^{1, 3}, Deshmukh, Kshitij ¹, Vallim, Thomas A. ⁷, Deja, Stanislaw ⁸, Burgess, Shawn C. ⁸, Taylor, Eric B. ^{1, 2, 3, 4, 5, 6, 10, ∗}

Publikováno v: In Cell Metabolism 7 January 2025 37(1):255-273

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones.

Autor: Rauckhorst AJ; Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA; Fraternal Order of Eagles Diabetes Research Center (FOEDRC), University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA; FOEDRC Metabolomics Core Research Facility, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA., Sheldon RD; Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA., Pape DJ; Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA., Ahmed A; Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA., Falls-Hubert KC; Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA., Merrill RA; Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA., Brown RF; Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA; FOEDRC Metabolomics Core Research Facility, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA., Deshmukh K; Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA., Vallim TA; Department of Biological Chemistry, University of California, Los Angeles (UCLA), David Geffen School of Medicine, Los Angeles, CA 90095, USA., Deja S; Center for Human Nutrition, University of Texas Southwestern, Dallas, TX 75390, USA., Burgess SC; Center for Human Nutrition, University of Texas Southwestern, Dallas, TX 75390, USA., Taylor EB; Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA; Fraternal Order of Eagles Diabetes Research Center (FOEDRC), University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA; FOEDRC Metabolomics Core Research Facility, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA; Holden Comprehensive Cancer Center, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA; Pappajohn Biomedical Institute, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA. Electronic address: eric-taylor@uiowa.edu.

Publikováno v: Cell metabolism [Cell Metab] 2024 Oct 25. Date of Electronic Publication: 2024 Oct 25.