Radiation nanomedicines for cancer treatment: a scientific journey and view of the landscape.

Autor: Reilly, Raymond M., Georgiou, Constantine J., Brown, Madeline K., Cai, Zhongli

Publikováno v: EJNMMI Radiopharmacy & Chemistry; 5/4/2024, Vol. 9 Issue 1, p1-47, 47p

Convection-enhanced delivery of [ ¹⁷⁷ Lu]Lu-labeled gold nanoparticles combined with anti-PD1 checkpoint immunotherapy improves the survival of immunocompetent C57BL/6J mice with orthotopic GL261 murine glioma tumors.

Autor: Georgiou CJ; Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada., Brown MK; Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada., Cai Z; Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada., Alshafai L; Department of Medical Imaging, University of Toronto, Toronto, ON, Canada; Joint Department of Medical Imaging, Division of Neuroradiology, Mount Sinai Hospital and University Health Network, Toronto, ON, Canada., Gao A; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Laboratory Medicine Program, University Health Network, Toronto, ON, Canada., Rutka JT; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada., Winnik MA; Department of Chemistry, University of Toronto, Toronto, ON, Canada., Reilly RM; Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada; Department of Medical Imaging, University of Toronto, Toronto, ON, Canada; Laboratory Medicine Program, University Health Network, Toronto, ON, Canada. Electronic address: raymond.reilly@utoronto.ca.

Publikováno v: Nuclear medicine and biology [Nucl Med Biol] 2024 Nov 09; Vol. 140-141, pp. 108970. Date of Electronic Publication: 2024 Nov 09.