Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2

Autor: Walls, Alexandra C., Fiala, Brooke, Schäfer, Alexandra, Wrenn, Samuel, Pham, Minh N., Murphy, Michael, Tse, Longping V., Shehata, Laila, O’Connor, Megan A., Chen, Chengbo, Navarro, Mary Jane, Miranda, Marcos C., Pettie, Deleah, Ravichandran, Rashmi, Kraft, John C., Ogohara, Cassandra, Palser, Anne, Chalk, Sara, Lee, E-Chiang, Guerriero, Kathryn, Kepl, Elizabeth, Chow, Cameron M., Sydeman, Claire, Hodge, Edgar A., Brown, Brieann, Fuller, Jim T., Dinnon, Kenneth H., III, Gralinski, Lisa E., Leist, Sarah R., Gully, Kendra L., Lewis, Thomas B., Guttman, Miklos, Chu, Helen Y., Lee, Kelly K., Fuller, Deborah H., Baric, Ralph S., Kellam, Paul, Carter, Lauren, Pepper, Marion, Sheahan, Timothy P., Veesler, David, King, Neil P.

Publikováno v: In Cell 25 November 2020 183(5):1367-1382

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Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2.

Autor: Walls AC; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Fiala B; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Schäfer A; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Wrenn S; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Pham MN; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Murphy M; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Tse LV; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Shehata L; Department of Immunology, University of Washington, Seattle, WA 98109, USA., O'Connor MA; Department of Microbiology, University of Washington, Seattle, WA 98109, USA.; Washington National Primate Research Center, Seattle, WA 98121, USA., Chen C; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.; Biological Physics Structure and Design Program, University of Washington, Seattle, WA 91895, USA., Navarro MJ; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Miranda MC; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Pettie D; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Ravichandran R; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Kraft JC; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Ogohara C; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Palser A; Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom., Chalk S; Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom., Lee EC; Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom., Kepl E; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Chow CM; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Sydeman C; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Hodge EA; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA., Brown B; Department of Microbiology, University of Washington, Seattle, WA 98109, USA.; Washington National Primate Research Center, Seattle, WA 98121, USA., Fuller JT; Department of Microbiology, University of Washington, Seattle, WA 98109, USA., Dinnon KH 3rd; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Gralinski LE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Leist SR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Gully KL; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Lewis TB; Department of Microbiology, University of Washington, Seattle, WA 98109, USA.; Washington National Primate Research Center, Seattle, WA 98121, USA., Guttman M; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA., Chu HY; Department of Medicine, University of Washington, Seattle, WA 98109, USA., Lee KK; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.; Biological Physics Structure and Design Program, University of Washington, Seattle, WA 91895, USA., Fuller DH; Department of Microbiology, University of Washington, Seattle, WA 98109, USA.; Washington National Primate Research Center, Seattle, WA 98121, USA.; Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA., Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Kellam P; Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.; Department of Infectious Disease, Imperial College London, United Kingdom., Carter L; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Pepper M; Department of Immunology, University of Washington, Seattle, WA 98109, USA., Sheahan TP; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Veesler D; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., King NP; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2020 Aug 12. Date of Electronic Publication: 2020 Aug 12.