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A photoswitchable GPCR-based opsin for presynaptic inhibition

Autor: Copits, Bryan A, Gowrishankar, Raaj, O’Neill, Patrick R, Li, Jun-Nan, Girven, Kasey S, Yoo, Judy J, Meshik, Xenia, Parker, Kyle E, Spangler, Skylar M, Elerding, Abigail J, Brown, Bobbie J, Shirley, Sofia E, Ma, Kelly K L, Vasquez, Alexis M, Stander, M Christine, Kalyanaraman, Vani, Vogt, Sherri K, Samineni, Vijay K, Patriarchi, Tommaso, Tian, Lin, Gautam, N, Sunahara, Roger K, Gereau, Robert W, Bruchas, Michael R

Publikováno v: Neuron, vol 109, iss 11

Optical manipulations of genetically defined cell types have generated significant insights into the dynamics of neural circuits. While optogenetic activation has been relatively straightforward, rapid and reversible synaptic inhibition has proven mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f608e4fb97a4857a82a05d65a3750e3e

A bistable inhibitory OptoGPCR for multiplexed optogenetic control of neural circuits.

Autor: Wietek J; Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel., Nozownik A; Center for Molecular Neurobiology, Hamburg, Germany.; Present address: Paris Brain Institute, Institut du Cerveau (ICM), CNRS UMR 7225, INSERM U1127, Sorbonne Université, Paris, France., Pulin M; Center for Molecular Neurobiology, Hamburg, Germany.; Present address: Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Saraf-Sinik I; Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel., Matosevich N; Sagol school of neuroscience, Tel Aviv University, Tel Aviv, Israel., Malan D; Institut für Physiologie I, Universität Bonn, Bonn, Germany., Brown BJ; Washington University Pain Center, Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA., Dine J; Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel.; Present address: Boehringer Ingelheim Pharma GmbH & Co. KG; CNS Diseases, Biberach an der Riss, Germany., Levy R; Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel., Litvin A; Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel., Regev N; Department of Physiology and Pharmacology, Tel Aviv University, Tel Aviv, Israel., Subramaniam S; Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel., Bitton E; Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel., Benjamin A; Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel., Copits BA; Washington University Pain Center, Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA., Sasse P; Institut für Physiologie I, Universität Bonn, Bonn, Germany., Rost BR; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Neuroscience Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany., Schmitz D; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Neuroscience Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Bernstein Center for Computational Neuroscience, Berlin, Germany.; Einstein Center for Neurosciences Berlin, Berlin, Germany.; Max-Delbrück Center for Molecular Medicine, Berlin, Germany., Soba P; Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; LIMES-Institute, University of Bonn, Bonn, Germany., Nir Y; Sagol school of neuroscience, Tel Aviv University, Tel Aviv, Israel.; Department of Physiology and Pharmacology, Tel Aviv University, Tel Aviv, Israel.; Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel., Wiegert JS; Center for Molecular Neurobiology, Hamburg, Germany.; Present address: MCTN, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany., Yizhar O; Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jul 02. Date of Electronic Publication: 2023 Jul 02.