Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Brown, Aidan I"'
Autor:
Kim, Junyeong L., Brown, Aidan I.
The endoplasmic reticulum (ER) is a network of sheet-like and tubular structures that spans much of a cell and contains molecules undergoing diffusive searches for targets, such as unfolded proteins searching for chaperones and recently-folded protei
Externí odkaz:
http://arxiv.org/abs/2402.03059
Autor:
Kischuck, Liam T, Brown, Aidan I
The endoplasmic reticulum (ER), a cellular organelle that forms a cell-spanning network of tubes and sheets, is an important location of protein synthesis and folding. When the ER experiences sustained unfolded protein stress, IRE1 proteins embedded
Externí odkaz:
http://arxiv.org/abs/2305.00971
Autor:
Konno, Tasuku, Parutto, Pierre, Crapart, Cécile C., Davì, Valentina, Bailey, David M.D., Awadelkareem, Mosab Ali, Hockings, Colin, Brown, Aidan I., Xiang, Katherine M., Agrawal, Anamika, Chambers, Joseph E., Vander Werp, Molly J., Koning, Katherine M., Elfari, Louis Mounir, Steen, Sam, Metzakopian, Emmanouil, Westrate, Laura M., Koslover, Elena F., Avezov, Edward
Publikováno v:
In Cell Reports 23 July 2024 43(7)
Autor:
Scott, Zubenelgenubi C., Brown, Aidan I., Mogre, Saurabh S., Westrate, Laura M., Koslover, Elena F.
Several organelles in eukaryotic cells, including mitochondria and the endoplasmic reticulum, form interconnected tubule networks extending throughout the cell. These tubular networks host many biochemical pathways that rely on proteins diffusively s
Externí odkaz:
http://arxiv.org/abs/2103.05065
Autor:
Brown, Aidan I, Koslover, Elena F
Newly-translated glycoproteins in the endoplasmic reticulum (ER) often undergo cycles of chaperone binding and release in order to assist in folding. Quality control is required to distinguish between proteins that have completed native folding, thos
Externí odkaz:
http://arxiv.org/abs/2008.05608
Autor:
Brown, Aidan I, Sivak, David A
Publikováno v:
Chemical Reviews, 120, 1, 434-459 (2020)
Biomolecular machines are protein complexes that convert between different forms of free energy. They are utilized in nature to accomplish many cellular tasks. As isothermal nonequilibrium stochastic objects at low Reynolds number, they face a distin
Externí odkaz:
http://arxiv.org/abs/1909.09180
We investigate diffusive search on planar networks, motivated by tubular organelle networks in cell biology that contain molecules searching for reaction partners and binding sites. Exact calculation of the diffusive mean first-passage time on a spat
Externí odkaz:
http://arxiv.org/abs/1905.05320
Publikováno v:
Phys. Rev. E 99, 062127 (2019)
Biomolecular machines transduce free energy from one form to another to fulfill many important roles inside cells, with dissipation required to achieve directed progress. We investigate how to break time-reversal symmetry at a given dissipation cost
Externí odkaz:
http://arxiv.org/abs/1812.07637
Autor:
Brown, Aidan I, Sivak, David A
Publikováno v:
Europhys. Lett. 126 (4), 40004 (2019)
Biomolecular motors use free energy to drive a variety of cellular tasks, including the transport of cargo, such as vesicles and organelles. We find that the widely-used `constant-force' approximation for the effect of cargo on motor dynamics leads t
Externí odkaz:
http://arxiv.org/abs/1805.08917
Autor:
Brown, Aidan I, Sivak, David A
Publikováno v:
J Phys Chem B 122(4), 1387-1393, 2018
Biomolecular machines transduce between different forms of energy. These machines make directed progress and increase their speed by consuming free energy, typically in the form of nonequilibrium chemical concentrations. Machine dynamics are often mo
Externí odkaz:
http://arxiv.org/abs/1710.10327