LION/web: a web-based ontology enrichment tool for lipidomic data analysis

Autor: Molenaar, M.R., Jeucken, A., Wassenaar, T.A., van der Lest, Chris H A, Brouwers, J.F.H.M., Helms, J.B.

A major challenge for lipidomic analyses is the handling of the large amounts of data and the translation of results to interpret the involvement of lipids in biological systems. We built a new lipid ontology (LION) that associates >50,000 lipid spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______101::45584b33c8c42a6b202f95c52808f5f3
https://dspace.library.uu.nl/handle/1874/387355

A Comprehensive Functional Characterization of Escherichia coli Lipid Genes

Autor: Jeucken, Aike, Molenaar, M.R., van de Lest, C.H.A., Jansen, J.W.A., Helms, J.B., Brouwers, J.F.H.M., dB&C FR-RMSC RMSC, Sub Biochemie Algemeen, LS Equine Muscoskeletal Biology, LS Veterinaire biochemie, Sub MS-faciliteit, dB&C FR-RMSC FR, Dep Biochemie en Celbiologie

Publikováno v: Cell Reports, Vol 27, Iss 5, Pp 1597-1606.e2 (2019)
Cell Reports, 27(5), 1597. Elsevier Saunders

Summary: Lipid membranes are the border between living cells and their environments. The membrane’s lipid composition defines fluidity, thickness, and protein activity and is controlled by the intricate actions of lipid gene-encoded enzymes. Howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96fa9628d7d1725d89a137a47a943695
https://pubmed.ncbi.nlm.nih.gov/31042483

The binding of phosphatidylcholine to the phosphatidylcholine transfer protein: affinity and role in folding

Autor: de Brouwer, A.P.M ^{a, *}, Bouma, B ^b, van Tiel, C.M ^a, Heerma, W ^c, Brouwers, J.F.H.M ^d, Bevers, L.E ^a, Westerman, J ^a, Roelofsen, B ^a, Wirtz, K.W.A ^a

Publikováno v: In Chemistry and Physics of Lipids 2001 112(2):109-119

Transportomics: screening for substrates of ABC transporters in body fluids using vesicular transport assays

Autor: Krumpochova, P, Sapthu, S., Brouwers, J.F.H.M., de Haas, M., de Vos, R., Borst, P., van de Wetering, K., Biology of Reproductive Cells, Membrane Enzymology, Sub Membrane Enzymology begr. 01-06-12, Dep Biochemie en Celbiologie

Publikováno v: FASEB Journal, 26, 738. FASEB
Krumpochova, P, Sapthu, S, Brouwers, J F, de Haas, M, de Vos, R, Borst, P & van de Wetering, K 2012, ' Transportomics: screening for substrates of ABC transporters in body fluids using vesicular transport assays ', FASEB Journal, no. 26, pp. 738-747 . https://doi.org/10.1096/fj.11-195743
FASEB Journal, 26(2), 738-747
FASEB Journal, 738-747. FASEB
ISSUE=26;STARTPAGE=738;ENDPAGE=747;ISSN=0892-6638;TITLE=FASEB Journal
FASEB journal, 26(2), 738-747. FASEB
FASEB Journal 26 (2012) 2

The ATP-binding cassette (ABC) genes encode the largest family of transmembrane proteins. ABC transporters translocate a wide variety of substrates across membranes, but their physiological function is often incompletely understood. We describe a new

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab8e53385c0cdd2b48e9cfd2e425cfe
https://dspace.library.uu.nl/handle/1874/276729

The yeast acyltransferase Sct1p regulates fatty acid desaturation by competing with the desaturase Ole1p

Autor: De Smet, C.H., Vittone, E., Scherer, M., Houweling, M., Liebisch, G., Brouwers, J.F.H.M., de Kroon, Toon

The degree of fatty acid unsaturation, that is, the ratio of unsaturated versus saturated fatty acyl chains, determines membrane fluidity. Regulation of expression of the fatty acid desaturase Ole1p was hitherto the only known mechanism governing the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______101::c514a018455bb12f9cc0c5b5aac6a59e
https://dspace.library.uu.nl/handle/1874/277020