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LC–MS/MS-based quantification of efflux transporter proteins at the BBB

Autor: Gomez-Zepeda, David, Taghi, Meryam, Smirnova, Maria, Sergent, Philippe, Liu, Wang-Qing, Chhuon, Cerina, Vidal, Michel, Picard, Martin, Thioulouse, Elizabeth, Broutin, Isabelle, Guerrera, Ida-Chiara, Scherrmann, Jean-Michel, Parmentier, Yannick, Decleves, Xavier, Menet, Marie-Claude

Publikováno v: In Journal of Pharmaceutical and Biomedical Analysis 5 February 2019 164:496-508

MexAB-OprM Efflux Pump Interaction with the Peptidoglycan of Escherichia coli and Pseudomonas aeruginosa

Autor: Ma, Miao, Lustig, Margaux, Salem, Michèle, Mengin-Lecreulx, Dominique, Phan, Gilles, Broutin, Isabelle

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2021, 22 (10), pp.5328. ⟨10.3390/ijms22105328⟩
International Journal of Molecular Sciences, Vol 22, Iss 5328, p 5328 (2021)
International Journal of Molecular Sciences, MDPI, 2021, 22 (10), pp.5328. ⟨10.3390/ijms22105328⟩
Volume 22
Issue 10

International audience; One of the major families of membrane proteins found in prokaryote genome corresponds to the transporters. Among them, the resistance-nodulation-cell division (RND) transporters are highly studied, as being responsible for one

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60aea63cedfe76f4517b889e89a84635
https://www.repository.cam.ac.uk/handle/1810/322777

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Studying dynamics without explicit dynamics: a structure-based study of the export mechanism by AcrB

Autor: Simsir, Méliné, Broutin, Isabelle, Mus-Veteau, Isabelle, Cazals, Frédéric

RND family proteins are transmembrane proteins identified as large spectrum drug transporters. A prototypical case in this superfamily, responsible for antibiotic resistance in selected gram negative bacteria, is AcrB. AcrB forms a trimer, which uses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::666dfea10f0e4a4b935df9cd81d2ed03
https://hal.inria.fr/hal-02532366/file/acrb.pdf