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Dose optimization in surgical prophylaxis: sub-inhibitory dosing of vancomycin increases rates of biofilm formation and the rates of surgical site infection.

Autor: Brothers, Kimberly M.¹ (AUTHOR), Parker, Dana M.¹ (AUTHOR), Taguchi, Masashi^1,2 (AUTHOR), Ma, Dongzhu¹ (AUTHOR), Mandell, Jonathan B.¹ (AUTHOR), Thurlow, Lance L.³ (AUTHOR), Byrapogu, Venkata C.¹ (AUTHOR), Urish, Kenneth L.^1,4 (AUTHOR) ken.urish@pitt.edu

Publikováno v: Scientific Reports. 3/21/2023, Vol. 13 Issue 1, p1-9. 9p.

Engineered peptide PLG0206 overcomes limitations of a challenging antimicrobial drug class.

Autor: Huang, David B.¹ (AUTHOR) david.huang@peptilogics.com, Brothers, Kimberly M.² (AUTHOR), Mandell, Jonathan B.² (AUTHOR), Taguchi, Masashi^2,3 (AUTHOR), Alexander, Peter G.² (AUTHOR), Parker, Dana M.² (AUTHOR), Shinabarger, Dean⁴ (AUTHOR), Pillar, Chris⁴ (AUTHOR), Morrissey, Ian⁵ (AUTHOR), Hawser, Stephen⁵ (AUTHOR), Ghahramani, Parviz⁶ (AUTHOR), Dobbins, Despina¹ (AUTHOR), Pachuda, Nicholas¹ (AUTHOR), Montelaro, Ronald⁷ (AUTHOR), Steckbeck, Jonathan D.¹ (AUTHOR), Urish, Kenneth L.^2,8,9 (AUTHOR) david.huang@peptilogics.com

Publikováno v: PLoS ONE. 9/16/2022, Vol. 17 Issue 9, p1-19. 19p.

SlpE is a calcium-dependent cytotoxic metalloprotease associated with clinical isolates of Serratia marcescens

Autor: Stella, Nicholas A., Callaghan, Jake D., Zhang, Liang, Brothers, Kimberly M., Kowalski, Regis P., Huang, Jean J., Thibodeau, Patrick H., Shanks, Robert M.Q.

Publikováno v: In Research in Microbiology July-August 2017 168(6):567-574

Blowing epithelial cell bubbles with GumB: ShlA-family pore-forming toxins induce blebbing and rapid cellular death in corneal epithelial cells.

Autor: Brothers, Kimberly M.^1,2, Callaghan, Jake D.^1,2, Stella, Nicholas A.^1,2, Bachinsky, Julianna M.^1,2, AlHigaylan, Mohammed^1,2, Lehner, Kara L.^1,2, Franks, Jonathan M.³, Lathrop, Kira L.¹, Collins, Elliot⁴, Schmitt, Deanna M.⁴, Horzempa, Joseph⁴, Shanks, Robert M. Q.^1,2 shanksrm@upmc.edu

Publikováno v: PLoS Pathogens. 6/20/2019, Vol. 15 Issue 6, p1-31. 31p.