Novel Bacteroides Vulgatus strain protects against gluten-induced break of human celiac gut epithelial homeostasis: a pre-clinical proof-of-concept study.

Autor: Tran T; Mucosal Immunology and Biology Research Center, Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Senger S; Center for Scientific Review, National Institutes of Health, Bethesda, MD, USA., Baldassarre M; NICU, University of Bari, Bari, Italy., Brosnan RA; Mucosal Immunology and Biology Research Center, Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Cristofori F; Pediatric Unit 'Bruno Trambusti', Osp Pediatrico Giovanni XXIII, University of Bari, Bari, Italy., Crocco M; Department of Pediatrics, IRCCS Ospedale Giannina Gaslini, Genova, Italy., De Santis S; Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Department of Pathology, Case Western University School of Medicine, Cleveland, OH, USA., Elli L; Celiac Disease Referral Center, Ospedale Maggiore Policlinico, Milan, Italy., Faherty CS; Mucosal Immunology and Biology Research Center, Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Francavilla R; Pediatric Unit 'Bruno Trambusti', Osp Pediatrico Giovanni XXIII, University of Bari, Bari, Italy., Goodchild-Michelman I; Mucosal Immunology and Biology Research Center, Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Kenyon VA; Mucosal Immunology and Biology Research Center, Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Leonard MM; Mucosal Immunology and Biology Research Center, Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Mass General for Children, Boston, MA, USA., Lima RS; Mucosal Immunology and Biology Research Center, Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Malerba F; Department of Pediatrics, IRCCS Ospedale Giannina Gaslini, Genova, Italy., Montuori M; Pediatric Gastroenterology Unit, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy., Morelli A; Pediatric Training Program, University of Salerno School of Medicine, Salerno, Italy., Norsa L; Pediatric Hepatology Gastroenterology and Transplant Unit, Ospedale Papa Giovanni XXIII Bergamo, Bergamo, Italy., Passaro T; Celiac Disease Referral Center, 'San Giovanni di Dio e Ruggi d'Aragona' University Hospital, Pole of Cava de' Tirreni, Salerno, Italy., Piemontese P; NICU, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy., Reed JC; Mucosal Immunology and Biology Research Center, Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Mass General for Children, Boston, MA, USA., Sansotta N; Pediatric Hepatology Gastroenterology and Transplant Unit, Ospedale Papa Giovanni XXIII Bergamo, Bergamo, Italy., Valitutti F; Pediatric Gastroenterology and Liver Unit, Santobono-Pausilipon Children's Hospital, Naples, Italy.; European Biomedical Research Institute of Salerno, Salerno, Italy., Zomorrodi AR; Mucosal Immunology and Biology Research Center, Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Fasano A; Mucosal Immunology and Biology Research Center, Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. afasano@mgh.harvard.edu.; Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Mass General for Children, Boston, MA, USA. afasano@mgh.harvard.edu.; European Biomedical Research Institute of Salerno, Salerno, Italy. afasano@mgh.harvard.edu.

Publikováno v: Pediatric research [Pediatr Res] 2024 Apr; Vol. 95 (5), pp. 1254-1264. Date of Electronic Publication: 2024 Jan 04.