AAV-mediated expression of galactose-1-phosphate uridyltransferase corrects defects of galactose metabolism in classic galactosemia patient fibroblasts.

Autor: Brophy ML; Rare Disease Research Unit, Pfizer, Inc., Cambridge, Massachusetts, USA., Stansfield JC; Early Clinical Development, Pfizer, Inc., Cambridge, Massachusetts, USA., Ahn Y; Target Sciences, Pfizer, Inc., Cambridge, Massachusetts, USA., Cheng SH; Rare Disease Research Unit, Pfizer, Inc., Cambridge, Massachusetts, USA., Murphy JE; Rare Disease Research Unit, Pfizer, Inc., Cambridge, Massachusetts, USA., Bell RD; Rare Disease Research Unit, Pfizer, Inc., Cambridge, Massachusetts, USA.

Publikováno v: Journal of inherited metabolic disease [J Inherit Metab Dis] 2022 May; Vol. 45 (3), pp. 481-492. Date of Electronic Publication: 2022 Jan 23.

Epsin-mediated degradation of IP3R1 fuels atherosclerosis.

Autor: Dong Y; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Lee Y; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Cui K; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., He M; Department of Medicine, University of California, San Diego, San Diego, CA, 92093, USA., Wang B; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Bhattacharjee S; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Zhu B; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Yago T; Cardiovascular Biology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA., Zhang K; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Deng L; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA., Ouyang K; Department of Medicine, University of California, San Diego, San Diego, CA, 92093, USA., Wen A; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Cowan DB; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Song K; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Yu L; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Brophy ML; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Liu X; Center for Vascular and Developmental Biology, Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Chicago, IL, 60611, USA., Wylie-Sears J; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Wu H; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Wong S; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Cui G; Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA., Kawashima Y; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.; Center for Disease Proteomics, Kitasato University School of Science, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0373, Japan., Matsumoto H; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA., Kodera Y; Center for Disease Proteomics, Kitasato University School of Science, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0373, Japan., Wojcikiewicz RJH; Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, 13210, USA., Srivastava S; Department of Medicine, Division of Cardiovascular Medicine, University of Louisville School of Medicine, Louisville, KY, 40202, USA., Bischoff J; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Wang DZ; Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Ley K; La Jolla Institute for Allergy and Immunology, La Jolla, CA, 92037, USA., Chen H; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA. hong.chen@childrens.harvard.edu.

Publikováno v: Nature communications [Nat Commun] 2020 Aug 07; Vol. 11 (1), pp. 3984. Date of Electronic Publication: 2020 Aug 07.

Myeloid-Specific Deletion of Epsins 1 and 2 Reduces Atherosclerosis by Preventing LRP-1 Downregulation.

Autor: Brophy ML; From the Vascular Biology Program and Department of Surgery, Boston Children's Hospital (M.L.B., Y.D., K.S., K.Z., A.W., H.W., Y.L., S.W., L.Y., J.B., H.C.), Harvard Medical School, MA.; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center (M.L.B.)., Dong Y; From the Vascular Biology Program and Department of Surgery, Boston Children's Hospital (M.L.B., Y.D., K.S., K.Z., A.W., H.W., Y.L., S.W., L.Y., J.B., H.C.), Harvard Medical School, MA., Tao H; Atherosclerosis Research Unit, Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (H.T., P.G.Y., M.F.L.)., Yancey PG; Atherosclerosis Research Unit, Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (H.T., P.G.Y., M.F.L.)., Song K; From the Vascular Biology Program and Department of Surgery, Boston Children's Hospital (M.L.B., Y.D., K.S., K.Z., A.W., H.W., Y.L., S.W., L.Y., J.B., H.C.), Harvard Medical School, MA., Zhang K; From the Vascular Biology Program and Department of Surgery, Boston Children's Hospital (M.L.B., Y.D., K.S., K.Z., A.W., H.W., Y.L., S.W., L.Y., J.B., H.C.), Harvard Medical School, MA.; Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China (K.Z.)., Wen A; From the Vascular Biology Program and Department of Surgery, Boston Children's Hospital (M.L.B., Y.D., K.S., K.Z., A.W., H.W., Y.L., S.W., L.Y., J.B., H.C.), Harvard Medical School, MA., Wu H; From the Vascular Biology Program and Department of Surgery, Boston Children's Hospital (M.L.B., Y.D., K.S., K.Z., A.W., H.W., Y.L., S.W., L.Y., J.B., H.C.), Harvard Medical School, MA., Lee Y; From the Vascular Biology Program and Department of Surgery, Boston Children's Hospital (M.L.B., Y.D., K.S., K.Z., A.W., H.W., Y.L., S.W., L.Y., J.B., H.C.), Harvard Medical School, MA., Malovichko MV; Division of Cardiovascular Medicine, Department of Medicine, University of Louisville, KY (M.V.M., S.D.S., S.S.)., Sithu SD; Division of Cardiovascular Medicine, Department of Medicine, University of Louisville, KY (M.V.M., S.D.S., S.S.)., Wong S; From the Vascular Biology Program and Department of Surgery, Boston Children's Hospital (M.L.B., Y.D., K.S., K.Z., A.W., H.W., Y.L., S.W., L.Y., J.B., H.C.), Harvard Medical School, MA., Yu L; From the Vascular Biology Program and Department of Surgery, Boston Children's Hospital (M.L.B., Y.D., K.S., K.Z., A.W., H.W., Y.L., S.W., L.Y., J.B., H.C.), Harvard Medical School, MA., Kocher O; Department of Pathology and Center for Vascular Biology Research, Beth Israel Medical Deaconess Medical Center (O.K.), Harvard Medical School, MA., Bischoff J; From the Vascular Biology Program and Department of Surgery, Boston Children's Hospital (M.L.B., Y.D., K.S., K.Z., A.W., H.W., Y.L., S.W., L.Y., J.B., H.C.), Harvard Medical School, MA., Srivastava S; Division of Cardiovascular Medicine, Department of Medicine, University of Louisville, KY (M.V.M., S.D.S., S.S.)., Linton MF; Atherosclerosis Research Unit, Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (H.T., P.G.Y., M.F.L.)., Ley K; Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA (K.L.)., Chen H; From the Vascular Biology Program and Department of Surgery, Boston Children's Hospital (M.L.B., Y.D., K.S., K.Z., A.W., H.W., Y.L., S.W., L.Y., J.B., H.C.), Harvard Medical School, MA.

Publikováno v: Circulation research [Circ Res] 2019 Feb 15; Vol. 124 (4), pp. e6-e19.

Endothelial epsins as regulators and potential therapeutic targets of tumor angiogenesis.

Autor: Song K; Vascular Biology Program, Karp Family Research Laboratory, Department of Surgery, Boston Children's Hospital, Harvard Medical School, 12.214, 300 Longwood Avenue, Boston, MA, 02115, USA., Wu H; Vascular Biology Program, Karp Family Research Laboratory, Department of Surgery, Boston Children's Hospital, Harvard Medical School, 12.214, 300 Longwood Avenue, Boston, MA, 02115, USA., Rahman HN; Vascular Biology Program, Karp Family Research Laboratory, Department of Surgery, Boston Children's Hospital, Harvard Medical School, 12.214, 300 Longwood Avenue, Boston, MA, 02115, USA., Dong Y; Vascular Biology Program, Karp Family Research Laboratory, Department of Surgery, Boston Children's Hospital, Harvard Medical School, 12.214, 300 Longwood Avenue, Boston, MA, 02115, USA., Wen A; Vascular Biology Program, Karp Family Research Laboratory, Department of Surgery, Boston Children's Hospital, Harvard Medical School, 12.214, 300 Longwood Avenue, Boston, MA, 02115, USA., Brophy ML; Vascular Biology Program, Karp Family Research Laboratory, Department of Surgery, Boston Children's Hospital, Harvard Medical School, 12.214, 300 Longwood Avenue, Boston, MA, 02115, USA., Wong S; Vascular Biology Program, Karp Family Research Laboratory, Department of Surgery, Boston Children's Hospital, Harvard Medical School, 12.214, 300 Longwood Avenue, Boston, MA, 02115, USA., Kwak S; Vascular Biology Program, Karp Family Research Laboratory, Department of Surgery, Boston Children's Hospital, Harvard Medical School, 12.214, 300 Longwood Avenue, Boston, MA, 02115, USA., Bielenberg DR; Vascular Biology Program, Karp Family Research Laboratory, Department of Surgery, Boston Children's Hospital, Harvard Medical School, 12.214, 300 Longwood Avenue, Boston, MA, 02115, USA., Chen H; Vascular Biology Program, Karp Family Research Laboratory, Department of Surgery, Boston Children's Hospital, Harvard Medical School, 12.214, 300 Longwood Avenue, Boston, MA, 02115, USA. hong.chen@childrens.harvard.edu.

Publikováno v: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2017 Feb; Vol. 74 (3), pp. 393-398. Date of Electronic Publication: 2016 Aug 29.

Role of endoplasmic reticulum stress signalling in diabetic endothelial dysfunction and atherosclerosis.

Autor: Dong Y; Vascular Biology Program, Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Fernandes C; Department of Biosciences, Rice University, Houston, TX, USA., Liu Y; Department of Internal Medicine, Charles R. Drew University of Medicine and Science, University of California-Los Angeles School of Medicine, Los Angeles, CA, USA., Wu Y; Department of Internal Medicine, Charles R. Drew University of Medicine and Science, University of California-Los Angeles School of Medicine, Los Angeles, CA, USA., Wu H; Vascular Biology Program, Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Brophy ML; Vascular Biology Program, Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Deng L; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Song K; Vascular Biology Program, Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Wen A; Vascular Biology Program, Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Wong S; Vascular Biology Program, Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Yan D; Department of Biology, Jinan University, Guangzhou, China., Towner R; Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma, OK, USA., Chen H; Vascular Biology Program, Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA hong.chen@childrens.harvard.edu.

Publikováno v: Diabetes & vascular disease research [Diab Vasc Dis Res] 2017 Jan; Vol. 14 (1), pp. 14-23. Date of Electronic Publication: 2016 Oct 20.