Mitochondria as Nutritional Targets to Maintain Muscle Health and Physical Function During Ageing.

Autor: Broome SC; Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC, 3000, Australia. sophie.broome@acu.edu.au., Whitfield J; Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC, 3000, Australia., Karagounis LG; Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC, 3000, Australia.; Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland., Hawley JA; Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC, 3000, Australia.

Publikováno v: Sports medicine (Auckland, N.Z.) [Sports Med] 2024 Sep; Vol. 54 (9), pp. 2291-2309. Date of Electronic Publication: 2024 Jul 26.

Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice.

Autor: Hedges CP; Discipline of Nutrition, School of Medical Sciences, University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand., Shetty B; Discipline of Nutrition, School of Medical Sciences, University of Auckland, Auckland, New Zealand., Broome SC; Discipline of Nutrition, School of Medical Sciences, University of Auckland, Auckland, New Zealand., MacRae C; Discipline of Nutrition, School of Medical Sciences, University of Auckland, Auckland, New Zealand., Koutsifeli P; Department of Physiology, School of Medical Sciences, University of Auckland, Auckland, New Zealand., Buckels EJ; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.; Molecular Medicine and Pathology, School of Medical Sciences, University of Auckland, Auckland, New Zealand., MacIndoe C; Department of Physiology, School of Medical Sciences, University of Auckland, Auckland, New Zealand., Boix J; Centre for Brain Research, University of Auckland, Auckland, New Zealand., Tsiloulis T; Discipline of Nutrition, School of Medical Sciences, University of Auckland, Auckland, New Zealand., Matthews BG; Molecular Medicine and Pathology, School of Medical Sciences, University of Auckland, Auckland, New Zealand., Sinha S; Department of Pathology, Waikato Hospital, Hamilton, New Zealand., Arendse M; Department of Pathology, Waikato Hospital, Hamilton, New Zealand., Jaiswal JK; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand., Mellor KM; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.; Department of Physiology, School of Medical Sciences, University of Auckland, Auckland, New Zealand., Hickey AJR; Applied Surgery and Metabolism Laboratory, School of Biological Sciences, University of Auckland, Auckland, New Zealand., Shepherd PR; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.; Molecular Medicine and Pathology, School of Medical Sciences, University of Auckland, Auckland, New Zealand., Merry TL; Discipline of Nutrition, School of Medical Sciences, University of Auckland, Auckland, New Zealand. t.merry@auckland.ac.nz.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand. t.merry@auckland.ac.nz.

Publikováno v: Nature aging [Nat Aging] 2023 Feb; Vol. 3 (2), pp. 162-172. Date of Electronic Publication: 2023 Jan 23.

MitoQ supplementation augments acute exercise-induced increases in muscle PGC1α mRNA and improves training-induced increases in peak power independent of mitochondrial content and function in untrained middle-aged men.

Autor: Broome SC; Discipline of Nutrition, School of Medical Sciences, University of Auckland, Auckland, New Zealand. Electronic address: s.broome@auckland.ac.nz., Pham T; Discipline of Nutrition, School of Medical Sciences, University of Auckland, Auckland, New Zealand; Auckland Bioengineering Institute, Faculty of Science, The University of Auckland, Auckland, New Zealand., Braakhuis AJ; Discipline of Nutrition, School of Medical Sciences, University of Auckland, Auckland, New Zealand., Narang R; School of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand., Wang HW; School of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand; School of Biological Sciences, Faculty of Science, The University of Auckland, Auckland, New Zealand., Hickey AJR; School of Biological Sciences, Faculty of Science, The University of Auckland, Auckland, New Zealand., Mitchell CJ; School of Kinesiology, University of British Columbia, Vancouver, Canada., Merry TL; Discipline of Nutrition, School of Medical Sciences, University of Auckland, Auckland, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.

Publikováno v: Redox biology [Redox Biol] 2022 Jul; Vol. 53, pp. 102341. Date of Electronic Publication: 2022 May 20.

Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance.

Autor: Xirouchaki CE; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia., Jia Y; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia., McGrath MJ; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia., Greatorex S; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia., Tran M; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia., Merry TL; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.; Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand., Hong D; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia., Eramo MJ; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia., Broome SC; Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand., Woodhead JST; Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand., D'souza RF; Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand., Gallagher J; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia., Salimova E; Monash Biomedical Imaging, Monash University, Clayton, Victoria 3800, Australia., Huang C; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.; Monash Proteomics and Metabolomics Facility, Monash University, Clayton, Victoria 3800, Australia., Schittenhelm RB; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.; Monash Proteomics and Metabolomics Facility, Monash University, Clayton, Victoria 3800, Australia., Sadoshima J; Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark, NJ 07103, USA., Watt MJ; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.; Department of Physiology, Monash University, Clayton, Victoria 3800, Australia., Mitchell CA; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia., Tiganis T; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.; Monash Metabolic Phenotyping Facility, Monash University, Clayton, Victoria 3800, Australia.

Publikováno v: Science advances [Sci Adv] 2021 Dec 17; Vol. 7 (51), pp. eabl4988. Date of Electronic Publication: 2021 Dec 15.

β-Catenin is required for optimal exercise- and contraction-stimulated skeletal muscle glucose uptake.

Autor: Masson SWC; Discipline of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand., Woodhead JST; Discipline of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand., D'Souza RF; Discipline of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand., Broome SC; Discipline of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., MacRae C; Discipline of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Cho HC; Discipline of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Atiola RD; Discipline of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Futi T; Discipline of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Dent JR; Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Shepherd PR; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.; Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Merry TL; Discipline of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.

Publikováno v: The Journal of physiology [J Physiol] 2021 Aug; Vol. 599 (16), pp. 3897-3912. Date of Electronic Publication: 2021 Jul 12.