Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukemia

Autor: Law, PJ, Berndt, SI, Speedy, HE, Camp, NJ, Sava, GP, Skibola, CF, Holroyd, A, Joseph, V, Sunter, NJ, Nieters, A, Bea, S, Monnereau, A, Martin-Garcia, D, Goldin, LR, Clot, G, Teras, LR, Quintela, I, Birmann, BM, Jayne, S, Cozen, W, Majid, A, Smedby, KE, Dearden, C, Brooks-Wilson, AR, Hall, AG, Purdue, MP, Mainou-Fowler, T, Vajdic, CM, Jackson, GH, Cocco, P, Marr, H, Zhang, Y, Zheng, T, Giles, GG, Lawrence, C, Call, TG, Liebow, M, Melbye, M, Glimelius, B, Mansouri, L, Glenn, M, Curtin, K, Diver, WR, Link, BK, Conde, L, Bracci, PM, Holly, EA, Jackson, RD, Tinker, LF, Benavente, Y, Boffetta, P, Brennan, P, Maynadie, M, McKay, J, Albanes, D, Weinstein, S, Wang, Z, Caporaso, NE, Morton, LM, Severson, RK, Riboli, E, Vineis, P, Vermeulen, RCH, Southey, MC, Milne, RL, Clavel, J, Topka, S, Spinelli, JJ, Kraft, P, Grazia Ennas, M, Summerfield, G, Ferri, GM, Harris, RJ, Miligi, L, Pettitt, AR, North, KE, Allsup, DJ, Fraumeni, JF, Bailey, JR, Offit, K, Pratt, G, Hjalgrim, H, Pepper, C, Chanock, SJ, Fegan, C, Rosenquist, R, De Sanjose, S, Carracedo, A, Dyer, MJS, Catovsky, D, Campo, E, Cerhan, JR, Allan, JM, Rothman, N, Houlston, R, Slager, S

Several chronic lymphocytic leukemia (CLL) susceptibility loci have been reported, however much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::f020bded01567c48e7dfd01ed27be13d
http://hdl.handle.net/10044/1/43261

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Correction: Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes.

Autor: Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA. berndts@mail.nih.gov., Vijai J; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Benavente Y; Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.; CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain., Camp NJ; Department of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Nieters A; Institute for Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany., Wang Z; Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, USA.; Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Smedby KE; Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Hematology Center, Karolinska University Hospital, Stockholm, Sweden., Kleinstern G; School of Public Health, University of Haifa, Haifa, Israel., Hjalgrim H; Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Haematology, Rigshospitalet, Copenhagen, Denmark.; Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark., Besson C; Centre Hospitalier de Versailles, Le Chesnay, France.; Université Paris-Saclay, UVSQ, Inserm, Équipe 'Exposome et Hérédité', CESP, Villejuif, France., Skibola CF; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA., Morton LM; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA., Brooks-Wilson AR; Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada.; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada., Teras LR; Department of Population Science, American Cancer Society, Atlanta, GA, USA., Breeze C; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA., Arias J; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA., Adami HO; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Institute of Health and Society, Clinical Effectiveness Research Group, University of Oslo, Oslo, Norway., Albanes D; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA., Anderson KC; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Ansell SM; Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA., Bassig B; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA., Becker N; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, Germany., Bhatti P; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Birmann BM; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Boffetta P; Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York, 11794, NY, USA.; Department of Medical and Surgical Sciences, University of Bologna, Bologna, 41026, Italy., Bracci PM; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA., Brennan P; International Agency for Research on Cancer (IARC), Lyon, France., Brown EE; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA., Burdett L; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, MA, USA., Cannon-Albright LA; Department of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA., Chang ET; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.; Center for Health Sciences, Exponent, Inc., Menlo Park, CA, USA., Chiu BCH; Department of Public Health Sciences University of Chicago, Chicago, IL, USA., Chung CC; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA., Clavel J; CRESS, UMR1153, INSERM, Villejuif, France.; Université de Paris-Cité, Villejuif, France., Cocco P; Centre for Occupational and Environmental Health, Division of Population Science, Health Services Research & Primary Care, University of Manchester, Manchester, UK., Colditz G; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA., Conde L; Bill Lyons Informatics Centre, UCL Cancer Institute, University College London, London, UK., Conti DV; Department of Population and Public Health Sciences, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Cox DG; INSERM U1052, Cancer Research Center of Lyon, Centre Léon Bérard, Lyon, France., Curtin K; Department of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Casabonne D; Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.; CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain., De Vivo I; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Diepstra A; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Diver WR; Department of Population Science, American Cancer Society, Atlanta, GA, USA., Dogan A; Departments of Laboratory Medicine and Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Edlund CK; Department of Population and Public Health Sciences, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Foretova L; Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic., Fraumeni JF Jr; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA., Gabbas A; Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, Cagliari, Italy., Ghesquières H; Department of Hematology, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre Benite, France.; CIRI, Centre International de Recherche en Infectiologie, Team Lymphoma Immuno-Biology, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France., Giles GG; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VC, Australia., Glaser S; Cancer Prevention Institute of California, Fremont, CA, USA.; Stanford Cancer Institute, Stanford, CA, USA., Glenn M; Department of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Glimelius B; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Gu J; Department of Epidemiology, MD Anderson Cancer Center, Houston, TX, USA., Habermann TM; Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA., Haiman CA; Department of Population and Public Health Sciences, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Haioun C; Lymphoid Malignancies Unit, Henri Mondor Hospital and University Paris Est, Créteil, France., Hofmann JN; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA., Holford TR; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA., Holly EA; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA., Hutchinson A; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, MA, USA., Izhar A; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Jackson RD; Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, OH, USA., Jarrett RF; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Kaaks R; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, Germany., Kane E; Department of Health Sciences, University of York, York, UK., Kolonel LN; Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA., Kong Y; Information Systems and Decision Sciences, California State University, Fullerton, Fullerton, CA, USA., Kraft P; Department of Epidemiology, Harvard T.H. 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Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA., Onel K; Donald and Barbara Zucker School of Medicine, Hofstra/Northwell, Hempstead, New York, NY, USA., Purdue MP; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA., Rand KA; Department of Population and Public Health Sciences, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Riboli E; School of Public Health, Imperial College London, London, United Kingdom., Riby J; Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA.; Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, CA, USA., Roman E; Department of Health Sciences, University of York, York, UK., Salles G; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sborov DW; Department of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Severson RK; 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Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.; Department of Histopathology, Douglass Hanly Moir Pathology, Sydney, NSW, Australia., Vachon CM; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Vajdic CM; The Kirby Institute, University of New South Wales, Sydney, NSW, Australia., Van Den Berg A; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Van Den Berg DJ; Department of Population and Public Health Sciences, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Vermeulen RCH; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Vineis P; MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Human Genetics Foundation, Turin, Italy., Wang SS; 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Publikováno v: Leukemia [Leukemia] 2023 Oct; Vol. 37 (10), pp. 2142.