Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Brooks G. Robinson"'
Autor:
Brooks G. Robinson, James R. Bunzow, Jonathan B. Grimm, Luke D. Lavis, Joshua T. Dudman, Jennifer Brown, Kim A. Neve, John T. Williams
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Dendritic release of dopamine activates dopamine D2 autoreceptors, which are inhibitory G protein-coupled receptors (GPCRs), to decrease the excitability of dopamine neurons. This study used tagged D2 receptors to identify the localization a
Externí odkaz:
https://doaj.org/article/cd52b855e0284c209df9fce0fd4cbae8
RIM is essential for stimulated but not spontaneous somatodendritic dopamine release in the midbrain
Autor:
Brooks G Robinson, Xintong Cai, Jiexin Wang, James R Bunzow, John T Williams, Pascal S Kaeser
Publikováno v:
eLife, Vol 8 (2019)
Action potentials trigger neurotransmitter release at active zones, specialized release sites in axons. Many neurons also secrete neurotransmitters or neuromodulators from their somata and dendrites. However, it is unclear whether somatodendritic rel
Externí odkaz:
https://doaj.org/article/d43753a1786341ae86e468de7555a641
Autor:
Susan R. Sesack, John T. Williams, Mason Trinkle, Savas Hetelekides, Judith Joyce Balcita-Pedicino, Brooks G. Robinson, Sue A. Aicher, Santiago De La Torre, James R. Bunzow, Joseph J. Lebowitz
Publikováno v:
Brain Struct Funct
G-Protein coupled D2 autoreceptors expressed on dopamine neurons (D2Rs) inhibit transmitter release and cell firing at axonal endings and somatodendritic compartments. Mechanistic details of somatodendritic dopamine release remain unresolved, partly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::182424b56c38689576e9d7e1ccd56bd8
https://doi.org/10.1007/s00429-021-02432-3
https://doi.org/10.1007/s00429-021-02432-3
Autor:
Brooks G Robinson, Alec F Condon, Daniela Radl, Emiliana Borrelli, John T Williams, Kim A Neve
Publikováno v:
eLife, Vol 6 (2017)
The dopamine D2 receptor has two splice variants, D2S (Short) and D2L (Long). In dopamine neurons, both variants can act as autoreceptors to regulate neuronal excitability and dopamine release, but the roles of each variant are incompletely character
Externí odkaz:
https://doaj.org/article/6247159021874db79607b5d47e0e255b
Autor:
Marlous C M van der Weijden, Dineke S. Verbeek, Michelle L Kielhold, John T. Williams, Kai Yu Ma, Kim A. Neve, Dayana Rodriguez-Contreras, Alec F. Condon, Claudia Dufke, Cathérine C.S. Delnooz, Brooks G. Robinson, Gilles N. Stormezand, Marina A. J. Tijssen
Publikováno v:
Movement Disorders, 36(3), 729-739. Wiley
Movement Disorders
Movement Disorders
Background We describe a 4-generation Dutch pedigree with a unique dominantly inherited clinical phenotype of a combined progressive chorea and cervical dystonia carrying a novel heterozygous dopamine D2 receptor (DRD2) variant. Objectives The object
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3aceca6a6bcfabd5c159cee522bcb7
https://doi.org/10.1002/mds.28385
https://doi.org/10.1002/mds.28385
Autor:
Stephanie C Gantz, Brooks G Robinson, David C Buck, James R Bunzow, Rachael L Neve, John T Williams, Kim A Neve
Publikováno v:
eLife, Vol 4 (2015)
D2 autoreceptors regulate dopamine release throughout the brain. Two isoforms of the D2 receptor, D2S and D2L, are expressed in midbrain dopamine neurons. Differential roles of these isoforms as autoreceptors are poorly understood. By virally express
Externí odkaz:
https://doaj.org/article/8ad20fd828744c2a90d9e5d99be6908d
Publikováno v:
Cell reports, vol 36, iss 5
Cell reports
Cell reports
SUMMARY Neuromodulation mediated by synaptically released endogenous transmitters acting in G-protein-coupled receptors (GPCRs) is slow primarily because of multistep downstream signaling. What is less well understood is the spatial and temporal kine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc1fdc9500f9943642b8443f827a7bf
https://escholarship.org/uc/item/85p4n2n5
https://escholarship.org/uc/item/85p4n2n5
Autor:
Brooks G Robinson, Sukant Khurana, Jascha B Pohl, Wen-ke Li, Alfredo Ghezzi, Amanda M Cady, Kristina Najjar, Michael M Hatch, Ruchita R Shah, Amar Bhat, Omar Hariri, Kareem B Haroun, Melvin C Young, Kathryn Fife, Jeff Hooten, Tuan Tran, Daniel Goan, Foram Desai, Farhan Husain, Ryan M Godinez, Jeffrey C Sun, Jonathan Corpuz, Jacxelyn Moran, Allen C Zhong, William Y Chen, Nigel S Atkinson
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37394 (2012)
Drosophila melanogaster has proven to be a useful model system for the genetic analysis of ethanol-associated behaviors. However, past studies have focused on the response of the adult fly to large, and often sedating, doses of ethanol. The pharmacol
Externí odkaz:
https://doaj.org/article/f53db8d35c1548d4878dd247cceb889a
Autor:
Kim A. Neve, John T. Williams, Brooks G. Robinson, Daniela Radl, Alec F. Condon, Emiliana Borrelli
Publikováno v:
Robinson, BG; Condon, AF; Radl, D; Borrelli, E; Williams, JT; & Neve, KA. (2017). Cocaine-induced adaptation of dopamine D2S, but not D2L autoreceptors. ELIFE, 6. doi: 10.7554/eLife.31924. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0rw2979g
eLife, Vol 6 (2017)
eLife
eLife, Vol 6 (2017)
eLife
The dopamine D2 receptor has two splice variants, D2S (Short) and D2L (Long). In dopamine neurons, both variants can act as autoreceptors to regulate neuronal excitability and dopamine release, but the roles of each variant are incompletely character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c136a751500af046509d6c88f7b7a4e3
https://escholarship.org/uc/item/0rw2979g
https://escholarship.org/uc/item/0rw2979g