The state-of-the-art of N-of-1 therapies and the IRDiRC N-of-1 development roadmap.

Autor: Jonker AH; HTSR, TechMed Centre, University of Twente, Enschede, The Netherlands., Tataru EA; French National Institute of Health and Medical Research (INSERM), Paris, France.; International Rare Diseases Research Consortium (IRDiRC), Paris, France., Graessner H; Centre for Rare Diseases, University Hospital Tübingen, Tübingen, Germany., Dimmock D; Creyon Bio, San Diego, CA, USA., Jaffe A; School of Clinical Medicine, University of New South Wales, Faculty of Medicine, Sydney, New South Wales, Australia., Baynam G; Rare Care Centre, Perth Children's Hospital, Perth, Western Australia, Australia.; University of Western Australia, Faculty of Health and Medical Sciences, Division of Paediatrics and Telethon Kids Institute, Perth, Western Australia, Australia.; University of Notre Dame, Medical Faculty, Sydney, New South Wales, Australia., Davies J; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; NIHR Blood and Transplant Research Unit in Precision Cellular Therapeutics, University of Oxford, Oxford, UK., Mitkus S; Patient Services, Global Genes, Aliso Viejo, CA, USA., Iliach O; Regulatory Strategy and Policy, Certara, Toronto, Ontario, Canada.; Canadian Organization for Rare Disorders (CORD), Toronto, Ontario, Canada., Horgan R; Cure Rare Disease, Woodbridge, CT, USA., Augustine EF; Clinical Trials Unit, Kennedy Krieger Institute, Baltimore, MD, USA., Bateman-House A; Division of Medical Ethics, Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA., Pasmooij AMG; Science Department, Dutch Medicines Evaluation Board, Utrecht, the Netherlands.; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands., Yu T; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA., Synofzik M; Research Division Translational Genomics of Neurodegenerative Diseases, Hertie-Institute of Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Division of Translational Genomics of Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Tübingen, Germany., Douville J; ASO Discovery and Development, n-Lorem Foundation, Carlsbad, CA, USA., Lapteva L; Division of Clinical Evaluation Pharmacology and Toxicology, Food and Drug Administration, Silver Spring, MD, USA., Brooks PJ; National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA., O'Connor D; Regulatory Policy & Early Access, The Association of the British Pharmaceutical Industry (ABPI), London, UK., Aartsma-Rus A; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. A.M.Aartsma-Rus@lumc.nl.

Publikováno v: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2024 Nov 04. Date of Electronic Publication: 2024 Nov 04.

Establishing minimal clinically important differences and patient acceptable symptom state thresholds following birmingham hip resurfacing.

Autor: Pasqualini I; Department of Orthopaedic Surgery, Orthopedic and Rheumatology Institute, Cleveland Clinic, 9500 Euclid Ave, A41, Cleveland, OH, 44195, USA., Huffman N; Department of Orthopaedic Surgery, Orthopedic and Rheumatology Institute, Cleveland Clinic, 9500 Euclid Ave, A41, Cleveland, OH, 44195, USA., Emara AK; Department of Orthopaedic Surgery, Orthopedic and Rheumatology Institute, Cleveland Clinic, 9500 Euclid Ave, A41, Cleveland, OH, 44195, USA., Klika AK; Department of Orthopaedic Surgery, Orthopedic and Rheumatology Institute, Cleveland Clinic, 9500 Euclid Ave, A41, Cleveland, OH, 44195, USA., McLaughlin JP; Department of Orthopaedic Surgery, Orthopedic and Rheumatology Institute, Cleveland Clinic, 9500 Euclid Ave, A41, Cleveland, OH, 44195, USA., Mesko N; Department of Orthopaedic Surgery, Orthopedic and Rheumatology Institute, Cleveland Clinic, 9500 Euclid Ave, A41, Cleveland, OH, 44195, USA., Brooks PJ; Department of Orthopaedic Surgery, Orthopedic and Rheumatology Institute, Cleveland Clinic, 9500 Euclid Ave, A41, Cleveland, OH, 44195, USA., Piuzzi NS; Department of Orthopaedic Surgery, Orthopedic and Rheumatology Institute, Cleveland Clinic, 9500 Euclid Ave, A41, Cleveland, OH, 44195, USA. piuzzin@ccf.org.; Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH, USA. piuzzin@ccf.org.

Publikováno v: Archives of orthopaedic and trauma surgery [Arch Orthop Trauma Surg] 2024 Aug; Vol. 144 (8), pp. 3729-3737. Date of Electronic Publication: 2024 Jul 09.

Coaching leaders toward favorable trajectories of burnout and engagement.

Autor: Brooks PJ; Institut d'Investigació en Psicologia dels Recursos Humans, del Desenvolupament Organitzacional, i de la Qualitat de Vida Laboral (Idocal), Universitat de València, Valencia, Spain., Ripoll P; Institut d'Investigació en Psicologia dels Recursos Humans, del Desenvolupament Organitzacional, i de la Qualitat de Vida Laboral (Idocal), Universitat de València, Valencia, Spain., Sánchez C; INTELEMA, Valencia, Spain., Torres M; INTELEMA, Valencia, Spain.

Publikováno v: Frontiers in psychology [Front Psychol] 2023 Dec 04; Vol. 14, pp. 1259672. Date of Electronic Publication: 2023 Dec 04 (Print Publication: 2023).

Metal-on-metal (MoM) hip implants and pregnancy: are MoM implants good for mom?-a systematic review.

Autor: Samuel LT; Department of Orthopaedic Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA., Rabin JM; Department of Orthopaedic Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA., Arnold NR; Department of Orthopaedic Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA., Munim M; Department of Orthopaedic Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA., Brooks PJ; Department of Orthopaedic Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA., Mont MA; Department of Orthopaedic Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA.; Department of Orthopaedic Surgery, Lenox Hill Hospital, Northwell Health, New York, NY, USA.

Publikováno v: Annals of translational medicine [Ann Transl Med] 2023 Aug 30; Vol. 11 (10), pp. 363. Date of Electronic Publication: 2019 Aug 07.

Hip resurfacing arthroplasty as an alternative to total hip arthroplasty in patients aged under 40 years.

Autor: Ramkumar PN; Hip Preservation Service, Hospital for Special Surgery, New York, New York, USA.; Long Beach Orthopaedic Institute, Long Beach, California, USA., Shaikh HJF; Department of Orthopaedic Surgery, Rochester, University of Rochester Medical Center, Rochester, New York, USA., Woo JJ; Department of Orthopaedic Surgery, Brown University, Warren Alpert School of Medicine, Providence, Rhode Island, USA., Haeberle HS; Hip Preservation Service, Hospital for Special Surgery, New York, New York, USA., Pang M; Department of Orthopaedic Surgery, Harvard Medical School, Cambridge, Massachusetts, USA., Brooks PJ; Cleveland Clinic Florida, Weston, Florida, USA.

Publikováno v: Bone & joint open [Bone Jt Open] 2023 Jun 01; Vol. 4 (6), pp. 408-415. Date of Electronic Publication: 2023 Jun 01.