Physiologically‐based pharmacokinetic modeling of remdesivir and its metabolites in pregnant women with COVID‐19

Autor: Xiaomei I. Liu, André Dallmann, Kristina Brooks, Brookie M. Best, Diana F. Clarke, Mark Mirochnick, John N. van denAnker, Edmund V. Capparelli, Jeremiah D. Momper

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 2, Pp 148-153 (2023)

Abstract Pregnant individuals are at high risk for severe illness from COVID‐19, and there is an urgent need to identify safe and effective therapeutics for this population. Remdesivir (RDV) is a SARS‐CoV‐2 nucleotide analog RNA polymerase inhi

Externí odkaz: https://doaj.org/article/d52f04c0444447639aa5582982613a39

Characterization of Plasma Protein Alterations in Pregnant and Postpartum Individuals Living With HIV to Support Physiologically-Based Pharmacokinetic Model Development

Autor: Sherry Zhao, Mary Gockenbach, Manuela Grimstein, Hari Cheryl Sachs, Mark Mirochnick, Kimberly Struble, Yodit Belew, Jian Wang, Edmund V. Capparelli, Brookie M. Best, Tamara Johnson, Jeremiah D. Momper, Anil R. Maharaj

Publikováno v: Frontiers in Pediatrics, Vol 9 (2021)

Background: Alterations in plasma protein concentrations in pregnant and postpartum individuals can influence antiretroviral (ARV) pharmacokinetics. Physiologically-based pharmacokinetic (PBPK) models can serve to inform drug dosing decisions in unde

Externí odkaz: https://doaj.org/article/255de7edd5bf4599bab6e29d0798c310

Maraviroc Population Pharmacokinetics Within the First 6 Weeks of Life

Autor: Marlon, Liyanage, Mina, Nikanjam, Lynn, McFadyen, Manoli, Vourvahis, Luise, Rogg, John, Moye, Ellen G, Chadwick, Patrick, Jean-Philippe, Mark, Mirochnick, Kyle, Whitson, Sarah, Bradford, Edmund V, Capparelli, Brookie M, Best

Publikováno v: Pediatric Infectious Disease Journal. 41:885-890

Treatment and prophylaxis options for neonatal HIV are limited. This study aimed to develop a population pharmacokinetic model to characterize the disposition of maraviroc in neonates to inform dosing regimens and expand available options.Using marav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2b75de34830d5d6dde44b52a11d6af
https://doi.org/10.1097/inf.0000000000003665

Efficacy and safety of three antiretroviral therapy regimens started in pregnancy up to 50 weeks post partum: a multicentre, open-label, randomised, controlled, phase 3 trial

Autor: Lameck Chinula, Lauren Ziemba, Sean Brummel, Katie McCarthy, Anne Coletti, Chelsea Krotje, Benjamin Johnston, Kevin Knowles, Sikhulile Moyo, Lynda Stranix-Chibanda, Risa Hoffman, Paul E Sax, Jeffrey Stringer, Nahida Chakhtoura, Patrick Jean-Philippe, Violet Korutaro, Haseena Cassim, Lee Fairlie, Gaerolwe Masheto, Ceejay Boyce, Lisa M Frenkel, K Rivet Amico, Lynette Purdue, Roger Shapiro, Blandina Theophil Mmbaga, Faeezah Patel, Jean van Wyk, James F Rooney, Judith S Currier, Shahin Lockman, Brookie M. Best, Cheryl D Blanchette, Renee Browning, Nagawa Jaliaah, Mark Mirochnick, William A. Murtaugh, Emmanuel Patras, Frances Whalen, Jeremiah D. Momper, Ponego L. Ponatshego, Lesedi Tirelo, Boitshepo J. Seme, Georginah O. Modise, Mpho S. Raesi, Marian E. Budu, Moakanyi Ramogodiri, Ricardo H. Oliveira, Cristina B Hofe, Thalita Fernandes de Abreu, Lorena M. Pestanha, Esaú João, Leon C. Sidi, Trevon Fuller, Maria L.S Cruz, Jorge Pinto, Flãvia Ferreira, Mãrio Correa Jr, Juliana Romeiro, Jose H. Pilotto, Luis E.B.C Fernandes, Luiz F. Moreira, Ivete M. Gomes, Shilpa Naik, Neetal Nevrekar, Vidya Mave, Aarti Kinikar, Elizea Horne, Hamisha Soma-Kasiram, Avy Violari, Sisinyana R. Mathiba, Mandisa Nyati, Gerhard Theron, Jeanne de Jager, Magdel Rossouw, Lindie Rossouw, Sherika Hanley, Alicia C. Desmond, Rosemary Gazu, Vani Govender, Amphan Chalermchockcharoenkit, Manopchai Thamkhantho, Peerawong Werarak, Supattra Rungmaitree, Jullapong Achalapong, Lukkana Sitiritkawin, Tim R. Cressey, Pra-ornsuda Sukrakanchana, Linda Aurpibul, Fuanglada Tongprasert, Chintana Khamrong, Sopida Kiattivej, Deo Wabwire, Enid Kabugo, Joel Maena, Frances Nakayiwa, Victoria Ndyanabangi, Beatrice Nagaddya, Rogers Sekabira, Justus Ashaba, Charles D. Mitchell, Adriana Drada, Grace A. Alvarez, Gwendolyn B. Scott, Mobeen Rathore, Saniyyah Mahmoudi, Adnan Shabbir, Nizar Maraqa, Patricia F. Mandima, Mercy Mutambanengwe, Suzen Maonera, Gift Chareka, Teacler Nematadzira, Vongai Chanaiwa, Taguma A. Matubu, Kevin Tamirepi, Sukunena Maturure, Tsungai Mhembere, Tichaona Vhembo, Tinashe Chidemo

Publikováno v: The Lancet HIV.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66eb7b2db986b5be5e1b778954e2df3d
https://doi.org/10.1016/s2352-3018(23)00061-9

Interactions between etonogestrel-releasing contraceptive implant and 3 antiretroviral regimens

Autor: Regis Kreitchmann, Jiajia Wang, Nahida Chakhtoura, Alice Stek, Edmund V. Capparelli, Ahizechukwu C. Eke, David Shapiro, Mark Mirochnick, Brookie M. Best, Impaact P s Protocol Team

Publikováno v: Contraception. 105:67-74

ObjectivesLong-acting reversible contraceptives are effective contraceptives for women with HIV, but there are limited data on etonogestrel implant and antiretroviral therapy pharmacokinetic drug-drug interactions. We evaluated etonogestrel/antiretro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d02a6e8b33a468a77bbd61948f4e4cb
https://doi.org/10.1016/j.contraception.2021.08.006