Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Brooke W. Walton-Strong"'
Autor:
Kristina K. Wolf, David J. Greenblatt, Steven A. Wrighton, Nadia Gorman, Brooke W. Walton-Strong, Frank J. Gonzalez, Qin Hao, Jacqueline F. Sinclair, Sheryl G. Wood, Elizabeth H. Jeffery, Peter R. Sinclair, Su X. Duan, Michael H. Court, Jenna L. Allard, Vsevolod E. Kostrubsky, Juliana G. Szakacs, Jane A. Hunt, Lisa L. von Moltke
Publikováno v:
Drug Metabolism and Disposition. 35:1223-1231
CYP2E1 is widely accepted as the sole form of cytochrome P450 responsible for alcohol-mediated increases in acetaminophen (APAP) hepatotoxicity. However, we previously found that alcohol [ethanol and isopentanol (EIP)] causes increases in APAP hepato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b40d44c01a5b83daca75eb458c75f9
https://doi.org/10.1124/dmd.107.014738
https://doi.org/10.1124/dmd.107.014738
Autor:
Kristina K, Wolf, Sheryl G, Wood, Jane A, Hunt, Brooke W, Walton-Strong, Kazuto, Yasuda, Lubin, Lan, Su X, Duan, Qin, Hao, Steven A, Wrighton, Elizabeth H, Jeffery, Ronald M, Evans, Juliana G, Szakacs, Lisa L, von Moltke, David J, Greenblatt, Michael H, Court, Erin G, Schuetz, Peter R, Sinclair, Jacqueline F, Sinclair
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 33(12)
The pregnane X receptor (PXR) is a transcriptional regulator of xenobiotic metabolizing enzymes, including cytochrome P450 3A (CYP3A), and transporters. Pretreatment of mice and rats with inducers of CYP3A increases acetaminophen (APAP) hepatotoxicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::876235da1054668e2b6ea093e4aabc3a
https://pubmed.ncbi.nlm.nih.gov/16141365
https://pubmed.ncbi.nlm.nih.gov/16141365
Autor:
Kristina K. Wolf, Jacqueline F. Sinclair, Elizabeth H. Jeffery, Juliana G. Szakacs, Lu-Bin Lan, Steven A. Wrighton, Peter R. Sinclair, David J. Greenblatt, Brooke W. Walton-Strong, Su X. Duan, Lisa L. von Moltke, Jane A. Hunt, Kazuto Yasuda, Sheryl G. Wood, Ronald M. Evans, Michael H. Court, Qin Hao, Erin G. Schuetz
Publikováno v:
Drug Metabolism and Disposition.
The pregnane X receptor (PXR) is a transcriptional regulator of xenobiotic metabolizing enzymes, including cytochrome P450 3A (CYP3A), and transporters. Pretreatment of mice and rats with inducers of CYP3A increases acetaminophen (APAP) hepatotoxicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::254702920382d5c14ce9cf14458de2f8
https://doi.org/10.1124/dmd.105.005256
https://doi.org/10.1124/dmd.105.005256