Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Brooke Swearingen"'
Autor:
Milica Perosevic, MD, Maria Martinez-Lage, MD, Brooke Swearingen, MD, Nicholas A. Tritos, MD, DSc
Publikováno v:
AACE Clinical Case Reports, Vol 8, Iss 2, Pp 85-88 (2022)
Background/Objective: CHEK2 is a cell-cycle checkpoint kinase and is part of the ATM-CHEK2-p53 cascade, which is protective against carcinogenesis. We describe a germline CHEK2 mutation in a patient with acromegaly and other tumors. Case Report: We p
Externí odkaz:
https://doaj.org/article/d43986464358489bb16df90a7ef7f631
Autor:
Jie Zhou, Yaomin Hu, Wende Zhu, Chuansheng Nie, Wenxiu Zhao, Alexander T. Faje, Kay E. Labelle, Brooke Swearingen, Hang Lee, E. Tessa Hedley-Whyte, Xun Zhang, Pamela S. Jones, Karen K. Miller, Anne Klibanski, Yunli Zhou, Roy J. Soberman
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
IntroductionAngiogenesis in pituitary tumors is not fully understood, and a better understanding could help inform new pharmacologic therapies, particularly for aggressive pituitary tumors.Materials and Methods219 human pituitary tumors and 12 normal
Externí odkaz:
https://doaj.org/article/47bb963aef744161bbbf0c8bfbe4471c
Autor:
Wenxiu Zhao, Xiaobin Jiang, Karrin Weisenthal, Jun Ma, Erin M. Botticelli, Yunli Zhou, E. Tessa Hedley-Whyte, Baiyao Wang, Brooke Swearingen, Roy J. Soberman, Anne Klibanski, Xun Zhang
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Epigenetic modification of chromatin is involved in non-malignant pituitary neoplasia by causing abnormal expression of tumor suppressors and oncogenes. These changes are potentially reversible, suggesting the possibility of targeting tumor cells by
Externí odkaz:
https://doaj.org/article/a51b38507b564d47a8b6de4809019a77
Autor:
Melanie Schorr, MD, Xun Zhang, PhD, Wenxiu Zhao, PhD, Parisa Abedi, MD, Kate E. Lines, PhD, Essa Te Hedley-Whyte, MD, Brooke Swearingen, MD, Anne Klibanski, MD, Karen K. Miller, MD, Rajesh V. Thakker, MD, FRS, Lisa B. Nachtigall, MD
Publikováno v:
AACE Clinical Case Reports, Vol 5, Iss 5, Pp e276-e281 (2019)
ABSTRACT: Objective: To report the first case of 2 synchronous pituitary adenomas, 1 corticotroph and 1 somatotroph, with distinct molecular lineages confirmed by differential hormone and S-100 protein expression. Methods: A case report followed by a
Externí odkaz:
https://doaj.org/article/74131b701c514b6ca37dc79711dd4abd
Publikováno v:
Case Reports in Ophthalmology, Vol 3, Iss 2, Pp 190-195 (2012)
Pituicytomas are rare neoplasms of the sellar region. We report a case of vision loss and a junctional scotoma in a 43-year-old woman caused by compression of the optic chiasm by a pituitary tumor. The morphological and immunohistochemical characteri
Externí odkaz:
https://doaj.org/article/3927dad5b802481eb392274dbae5394c
Autor:
Amy J. Wisdom, M. Aiven Dyer, Nora K. Horick, Beow. Y. Yeap, Karen K. Miller, Brooke Swearingen, Jay S. Loeffler, Helen A. Shih
Purpose The quality of life (QoL) impact of multidisciplinary treatment for patients with nonfunctioning pituitary macroadenomas (NFPMA) is unclear. We sought to investigate associations between patient factors, clinical data, and patient-reported Qo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e48b8c4668d3d26d0d99526492d2e1a4
https://doi.org/10.21203/rs.3.rs-2904379/v1
https://doi.org/10.21203/rs.3.rs-2904379/v1
Autor:
Pamela S. Jones, Brooke Swearingen
Publikováno v:
Pituitary. 25:713-717
Autor:
Allison Kimball, Laura E. Dichtel, Kevin C. J. Yuen, Whitney W. Woodmansee, Melanie S. Haines, Lisa B. Nachtigall, Brooke Swearingen, Pamela Jones, Nicholas A. Tritos, Julie L. Sharpless, Ursula B. Kaiser, Anu Gerweck, Karen K. Miller
Publikováno v:
Pituitary
PURPOSE: To assess long-term quality of life (QoL) in patients with sustained biochemical control of acromegaly, comparing those receiving vs not receiving pharmacotherapy (primary analysis); to assess change in QoL over time (secondary analysis). ME
Publikováno v:
AACE Clinical Case Reports. 8:85-88
Background / objective CHEK2 is a cell-cycle check point kinase and is part of the ATM-CHEK2-p53 cascade, which is protective against carcinogenesis. To describe a germline CHEK2 mutation in a patient with acromegaly and other tumors. Case report We
Autor:
Matthew J. Koch, Navid Redjal, Marc R. Bussière, Brooke Swearingen, Trevor J. Royce, Jay S. Loeffler, Pankaj K Agarwalla
Publikováno v:
Neurosurgery. 87:754-760
Background Rathke cleft cysts (RCCs) are sellar-based cystic lesions that are often found incidentally but occasionally become symptomatic with significant visual and/or endocrine deficits. The standard of treatment is surgery, but rare cases of mult