Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Brooke R Snyder"'
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9347 (2010)
BACKGROUND:Implantation of human multipotent stromal cells from bone marrow (hMSCs) into the dentate gyrus of the hippocampus of mice was previously shown to stimulate proliferation, migration and neural differentiation of endogenous neural stem cell
Externí odkaz:
https://doaj.org/article/b9d65dd8768e47b7ba0ac4acfddb2d3f
A conditioning lesion provides selective protection in a rat model of Amyotrophic Lateral Sclerosis.
Autor:
Colin K Franz, Eric T Quach, Christina A Krudy, Thais Federici, Michele A Kliem, Brooke R Snyder, Bethwel Raore, Nicholas M Boulis
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7357 (2009)
BACKGROUND:Amyotrophic Lateral Sclerosis (ALS) is neurodegenerative disease characterized by muscle weakness and atrophy due to progressive motoneuron loss. The death of motoneuron is preceded by the failure of neuromuscular junctions (NMJs) and axon
Externí odkaz:
https://doaj.org/article/90b32f7c00244afcb29f10012761057f
Autor:
Eleanor M. Donnelly, Eric T. Quach, Terence M. Hillery, Brenten L. Heeke, Brooke R. Snyder, Chalonda R. Handy, Deirdre M. O'Connor, Nicholas M. Boulis, Thais Federici
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 3, Pp 992-998 (2012)
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease, which is the leading genetic cause of mortality in children. To date no effective treatment exists for SMA. The genetic basis for SMA has been well documented as a mutatio
Externí odkaz:
https://doaj.org/article/8b865ceb2cc341f8b50a0739c7a8b385
Autor:
Anthony W.S. Chan, Brooke R. Snyder
Huntington’s disease (HD) is a complex neurodegenerative disorder that has no cure. Although treatments can often be given to relieve symptoms, the neuropathology associated with HD cannot be stopped or reversed. HD is characterized by degeneration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f8d428ddc1a50c9d496a50d136d1f0
https://europepmc.org/articles/PMC5826848/
https://europepmc.org/articles/PMC5826848/
Autor:
Eric T. Quach, Thais Federici, Nicholas M. Boulis, Chalonda R. Handy, Eleanor M. Donnelly, Brooke R. Snyder, Brenten L. Heeke, Deirdre M. O’Connor, Terence M. Hillery
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 3, Pp 992-998 (2012)
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease, which is the leading genetic cause of mortality in children. To date no effective treatment exists for SMA. The genetic basis for SMA has been well documented as a mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee5215143faed197d6e55950fa4c593
http://www.sciencedirect.com/science/article/pii/S0969996111003937
http://www.sciencedirect.com/science/article/pii/S0969996111003937
Autor:
Nicholas M. Boulis, Brenten L. Heeke, Brooke R. Snyder, Bethwel Raore, Thais Federici, Colin K. Franz, S. Kaye Spratt, Igor Radovitskiy, Michele A. Kliem, Emily M. Barrow
Publikováno v:
Amyotrophic Lateral Sclerosis. 12:331-339
Amyotrophic lateral sclerosis (ALS) is characterized by motor neuron loss leading to paralysis and death. Vascular endothelial growth factor (VEGF) has angiogenic, neurotrophic, and neuroprotective properties, and has preserved neuromuscular function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639f4c7bc017f5047c845802b3532de6
https://doi.org/10.3109/17482968.2011.574142
https://doi.org/10.3109/17482968.2011.574142
Autor:
Nicholas M. Boulis, Cary H. Leung, Michele A. Kliem, Brenten L. Heeke, Thais Federici, Scott W J McPhee, Brooke R. Snyder
Publikováno v:
Stereotactic and Functional Neurosurgery. 89:275-285
Background/Aims: Expression of the neuropeptide galanin in hippocampal neurons reduces seizures in the kainic acid rodent model of epilepsy. In order to translate these findings into a human clinical trial, the safety and feasibility of hippocampal a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9914b743e01751f3c251deec862678
https://doi.org/10.1159/000328265
https://doi.org/10.1159/000328265
Autor:
Zhi Hui Fang, Anthony W.S. Chan, Heather Banta, Xiao-Jiang Li, Brooke R. Snyder, Jun Liu, Shang Hsun Yang, Jin Jing Yang, Jack Orkin, Katherine Larkin, Jocelyne Bachevalier, Karolina Piotrowska-Nitsche, Eric C.H. Cheng, Yoland Smith, Stuart M. Zola, Pei Hsun Cheng, Shihua Li
Publikováno v:
Nature. 453:921-924
Huntington's disease is a severely disabling and lethal neurodegenerative disorder. The development of a non-human primate model for the disease would be invaluable in understanding its pathology and in developing therapeutic strategies, and this pap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676aaf842177c518fab05a37e64a28bf
https://doi.org/10.1038/nature06975
https://doi.org/10.1038/nature06975
Autor:
Brooke R. Snyder, Shang Hsun Yang, Jinjing Yang, Pei Hsun Cheng, Anderson Hsien-Cheng Huang, Anthony W.S. Chan
Publikováno v:
BMC Cell Biology
BMC Cell Biology, Vol 12, Iss 1, p 39 (2011)
BMC Cell Biology, Vol 12, Iss 1, p 39 (2011)
Background Dental pulp stem/stromal cells (DPSCs) are categorized as adult stem cells (ASCs) that retain multipotent differentiation capabilities. DPSCs can be isolated from individuals at any age and are considered to be true personal stem cells, ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d71d6df04b919dcbcfe73f10eeb4e4fe
https://doi.org/10.1186/1471-2121-12-39
https://doi.org/10.1186/1471-2121-12-39
Comparison of adeno-associated viral vector serotypes for spinal cord and motor neuron gene delivery
Autor:
Thais Federici, Steven J. Gray, R. Jude Samulski, Jeremiah W. Huang, Cary H. Leung, Brooke R. Snyder, Eric T. Quach, Nicholas M. Boulis
Publikováno v:
Human gene therapy. 22(9)
Gene therapy for motor neuron diseases requires efficient gene delivery to motor neurons (MNs) throughout the spinal cord and brainstem. The present study compared adeno-associated viral (AAV) vector serotypes 1, 6, 8, and 9 for spinal cord delivery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00f64f1361707947738ccfcc6c66a33
https://pubmed.ncbi.nlm.nih.gov/21443428
https://pubmed.ncbi.nlm.nih.gov/21443428