Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Brooke N. Kielkowski"'
Autor:
Tasneem A. Arsiwala, Samuel A. Sprowls, Kathryn E. Blethen, Ross A. Fladeland, Cullen P. Wolford, Brooke N. Kielkowski, Morgan J. Glass, Peng Wang, Olivia Wilson, Jeffrey S. Carpenter, Manish Ranjan, Victor Finomore, Ali Rezai, Paul R. Lockman
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-11 (2022)
Abstract Background Systemic drug delivery to the central nervous system is limited by presence of the blood–brain barrier (BBB). Low intensity focused ultrasound (LiFUS) is a non-invasive technique to disrupt the BBB, though there is a lack of und
Externí odkaz:
https://doaj.org/article/ba4277831ec64d7eb08e3d7f77c1ff57
Autor:
Tasneem A. Arsiwala, Kathryn E. Blethen, Cullen P. Wolford, Dhruvi M. Panchal, Samuel A. Sprowls, Ross A. Fladeland, Brooke N. Kielkowski, Trenton A. Pritt, Peng Wang, Olivia Wilson, Jeffrey S. Carpenter, Victor Finomore, Ali Rezai, Paul R. Lockman
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Patients with metastatic breast cancer have high and continually increasing rates of brain metastases. During the course of the disease, brain metastases can occur in up to 30% of these patients. In most cases, brain metastases are diagnosed after si
Externí odkaz:
https://doaj.org/article/773747cdbf62440fa2b2e84f5e8746f5
Autor:
Trenton A Pritt, Samuel A. Sprowls, Kathryn E Blethen, Tasneem Arsiwala, Brooke N. Kielkowski, Morgan J Glass, Yssabela M Cabuyao, Sonikpreet Aulakh, Ross Fladeland, Dhruvi M Panchal, Chris E. Adkins, Leland E Earp, Paul R. Lockman
Publikováno v:
Neuro-oncology Advances
The blood-brain barrier is the selectively permeable vasculature of the brain vital for maintaining homeostasis and neurological function. Low permeability is beneficial in the presence of toxins and pathogens in the blood. However, in the presence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350c5824fc01801d636a5dfbfb602b11
https://doi.org/10.1093/noajnl/vdab123
https://doi.org/10.1093/noajnl/vdab123
Autor:
Samuel A. Sprowls, W. Pentz, Manish Ranjan, A. Gabriele, Brooke N. Kielkowski, Jeffrey S Carpenter, Pushkar Saralkar, Rashi I. Mehta, Paul R. Lockman, Ross Fladeland, Peng Wang, Tasneem Arsiwala, Chris E. Adkins, Kathryn E Blethen, Ali R. Rezai, Umer Najib
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 7, Pp 676-691 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 7, Pp 676-691 (2021)
The blood-brain barrier (BBB) is a major anatomical and physiological barrier limiting the passage of drugs into brain. Central nervous system tumors can impair the BBB by changing the tumor microenvironment leading to the formation of a leaky barrie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bce52dd68e77db39bf5423f5169f36
http://europepmc.org/articles/PMC8208897
http://europepmc.org/articles/PMC8208897
Autor:
Samuel Adam Sprowls, Tasneem A Arsiwala, Brooke N Kielkowski, Vincenzo Pizzuti, R. Alfredo C. Siochi, Paul R Lockman
Background Brain metastasis is a devastating stage of cancer progression, occurring in ~30% of metastatic breast cancer patients. Two-year survival rates for these patients is low, and most typically survive less than one year. Treatments for these w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0b40d9476bf78c3ef7e682e50714690
https://doi.org/10.21203/rs.2.23290/v1
https://doi.org/10.21203/rs.2.23290/v1
Autor:
Neal Shah, Ross Fladeland, Paul R. Lockman, Tasneem Arsiwala, Kathryn E Blethen, Dhruvi M Panchal, Weimin Gao, Brooke N. Kielkowski, Samuel A. Sprowls
Publikováno v:
Neuro-Oncology Advances. 3:iv8-iv8
Lung cancer is the most prevalent malignancy to affect both men and women. Around 80% of all lung cancers are classified as non-small cell lung cancer (NSCLC). This subtype of lung cancer is also the most likely to metastasize to the brain. Clinicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9151b36cd81fa10149c9d01b1dd06f41
https://doi.org/10.1093/noajnl/vdab112.030
https://doi.org/10.1093/noajnl/vdab112.030
Autor:
Tasneem Arsiwala, Jacob R. Bumgarner, Neal Shah, Paul R. Lockman, Samuel A. Sprowls, Brooke N. Kielkowski, Sundus S. Lateef
Publikováno v:
Trends Cancer
Brain metastases encompass nearly 80% of all intracranial tumors. A late stage diagnosis confers a poor prognosis, with patients typically surviving less than two years. Poor survival can be equated to limited effective treatment modalities. One reas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c2c7390ad01e38aa774e3153e46300
https://europepmc.org/articles/PMC6703178/
https://europepmc.org/articles/PMC6703178/