Výsledky vyhledávání - "Brooke McDonough"

Abstract LB320: Discovery and characterization of QTX3034, a potent, selective, and orally bioavailable allosteric KRAS inhibitor

Autor: Yang W. Zhang, Dave Rominger, Elizabeth Donohue Vo, Jillian M. Silva, Yang J. Zhang, Greg Lee, John Micozzi, Ben Reid, Brooke McDonough, Audrey Hospital, Juan I. Luengo, Cameron Pitt, Hong Lin

Publikováno v: Cancer Research. 83:LB320-LB320

The RAS family of proto-oncogenes are the most frequently mutated genes in cancer, in which mutations in KRAS account for approximately 25% of all human cancers. RAS oncogenes impair the ability of RAS to convert from its active GTP-bound form into i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a5595ba42653b90cf20359e7908ebc4
https://doi.org/10.1158/1538-7445.am2023-lb320

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Abstract LBA007: Discovery and characterization of oncogenic KRAS:RAF1 conformational modulators with in vitro and in vivo MAPK inhibition

Autor: Elizabeth Donohue Vo, Juan Luengo, Hong Lin, Jerry Chen, Ben Reid, Brooke McDonough, Norman Fultang, Jillian Silva, Cameron Pitt

Publikováno v: Molecular Cancer Therapeutics. 20:LBA007-LBA007

Oncogenic mutations in the RAS family are the most frequently occurring among human cancers. The recent development of KRAS-targeted covalent inhibitors display efficacy in KRAS-mutant tumors; however, this approach is limited to KRASG12C mutant canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ad9d142c7ca3dd2ba5911a102ab78a9
https://doi.org/10.1158/1535-7163.targ-21-lba007

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