Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Brooke Ligon"'
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 289:G686-G695
Pancreatic acini secrete digestive enzymes in response to a variety of secretagogues including CCK and agonists acting via proteinase-activated receptor-2 (PAR2). We employed the CCK analog caerulein and the PAR2-activating peptide SLIGRL-NH2to compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e821aaf548d9be9ed4a3b91dd6b231c6
https://doi.org/10.1152/ajpgi.00342.2004
https://doi.org/10.1152/ajpgi.00342.2004
Autor:
Michael L. Steer, Arun Gopal, George Perides, Patricia Andrade-Gordon, Brooke Ligon, Xiaohong Tao, Anupriya Sharma
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 288:G388-G395
Protease-activated receptor-2 (PAR-2) is a widely expressed tethered ligand receptor that can be activated by trypsin and other trypsin-like serine proteases. In the exocrine pancreas, PAR-2 activation modulates acinar cell secretion of digestive enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17fe6e886000d0594daf625811cb6d01
https://doi.org/10.1152/ajpgi.00341.2004
https://doi.org/10.1152/ajpgi.00341.2004
Autor:
Michael B. Wheeler, H. Yoo-Warren, Y. Tanizawa, Aubrey E. Boyd, Xing-Hong Leng, Joseph S. Dillon, Brooke Ligon, D. U. Rabin, M. A. Permutt
Publikováno v:
Endocrinology. 133:1907-1910
Truncated forms of glucagon-like peptide-1 are the most potent endogenous stimuli of insulin secretion and have powerful antidiabetogenic effects. To determine the structure and coupling mechanisms of the human GLP-1 receptor we have isolated two pan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47539d9ece4d5227425ca4a95f4cd6ab
https://doi.org/10.1210/endo.133.4.8404634
https://doi.org/10.1210/endo.133.4.8404634
Autor:
Arun Gopal, Xiaohong Tao, Anupriya Sharma, Brooke Ligon, George Perides, K.W. Dwyer, Michael L. Steer
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 289(4)
Supramaximal stimulation of the rat pancreas with CCK, or its analog caerulein, triggers acute pancreatitis and a number of pancreatitis-associated acinar cell changes including intracellular activation of digestive enzyme zymogens and acinar cell in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43b00a1350a5227f36415c785fa75a0
https://pubmed.ncbi.nlm.nih.gov/15920015
https://pubmed.ncbi.nlm.nih.gov/15920015
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 19(5)
Glucagon-like peptide 1 (GLP-1) is a physiological stimulus of pancreatic beta-cell function. This enteroendocrine hormone is produced by intestinal L cells, and is delivered via the bloodstream to GLP-1 receptors (GLP-1Rs) on pancreatic beta-cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d9358e922182cadc0d2138dd03c674
https://pubmed.ncbi.nlm.nih.gov/15677711
https://pubmed.ncbi.nlm.nih.gov/15677711
Publikováno v:
The Journal of biological chemistry. 273(22)
The initiation of insulin release from rat islet beta cells relies, in large part, on calcium influx through dihydropyridine-sensitive (alpha1D) voltage-gated calcium channels. Components of calcium-dependent insulin secretion and whole cell calcium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d3f5805302fb452a04f6b62a8e0ee4
https://pubmed.ncbi.nlm.nih.gov/9593738
https://pubmed.ncbi.nlm.nih.gov/9593738
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781489918215
At similar plasma glucose concentrations much greater insulin secretion is achieved with oral glucose than with intravenous glucose. These observations lead to the concept that gastrointestinal factors (incretins) are released by nutrients, particula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d6edd6db277e57e6bc5bc6042cc3df4
https://doi.org/10.1007/978-1-4899-1819-2_15
https://doi.org/10.1007/978-1-4899-1819-2_15
