Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Brooke Levin"'
Autor:
Sukh Makhnoon, Brooke Levin, Megan Ensinger, Kristin Mattie, Robert J. Volk, Zhongming Zhao, Tito Mendoza, Sanjay Shete, Laila Samiian, Generosa Grana, Andrew Grainger, Banu Arun, Brian H. Shirts, Susan K. Peterson
Publikováno v:
Cancer Medicine, Vol 12, Iss 3, Pp 2875-2884 (2023)
Abstract Background Clinical interpretation of genetic test results is complicated by variants of uncertain significance (VUS) that have an unknown impact on health but can be clarified through reclassification. There is little empirical evidence reg
Externí odkaz:
https://doaj.org/article/acfe02508a074b7284c546f73e104e7b
Publikováno v:
Gynecologic Oncology Reports, Vol 27, Iss , Pp 60-64 (2019)
Ovarian endometrioid adenocarcinoma with yolk sac component has been reported in fewer than twenty cases in the literature. A majority of the diagnoses are described in postmenopausal women without specific reference to germline genetic testing. We d
Externí odkaz:
https://doaj.org/article/7439ca0944e54b7590e97ea575fc757c
Autor:
Mingang Xu, Jeremy Horrell, Melinda Snitow, Jiawei Cui, Heather Gochnauer, Camille M. Syrett, Staci Kallish, John T. Seykora, Fei Liu, Dany Gaillard, Jonathan P. Katz, Klaus H. Kaestner, Brooke Levin, Corinne Mansfield, Jennifer E. Douglas, Beverly J. Cowart, Michael Tordoff, Fang Liu, Xuming Zhu, Linda A. Barlow, Adam I. Rubin, John A. McGrath, Edward E. Morrisey, Emily Y. Chu, Sarah E. Millar
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-21 (2017)
Human WNT10A mutations are associated with dental defects and adult onset ectodermal dysplasia. Xuet al. show that WNT10A-activated ß-catenin plays dual roles in adult epithelial progenitor proliferation and differentiation by complexing with KLF4 i
Externí odkaz:
https://doaj.org/article/155ddb06076c415fa01075d340f6d738
Autor:
Sukh Makhnoon, Minxing Chen, Brooke Levin, Megan Ensinger, Kristin D. Mattie, Generosa Grana, Sanjay Shete, Banu K. Arun, Susan K. Peterson
Publikováno v:
Cancer. 128:3709-3717
Use of surveillance mammography and magnetic resonance imaging (MRI) has been understudied among women with variant of uncertain significance (VUS) compared to pathogenic and likely pathogenic variants (P/LP).Using data from two cancer settings, we c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de7b35ba0a27859de8029dc6f8d115d8
https://doi.org/10.1002/cncr.34429
https://doi.org/10.1002/cncr.34429
Autor:
Kara N. Maxwell, Maureen E. Murphy, Raul C. Ribeiro, Gerard P. Zambetti, Richard W. Kriwacki, Sheri L. Spunt, Carolyn Fein Levy, Morris C. Edelman, Brooke Levin, Fergus J. Couch, Kelly McGoldrick, Stephanie Gutierrez, Jill S. Dolinsky, Kenneth Offit, Vijai Joseph, Judy E. Garber, Jill E. Stopfer, Jeffrey N. Weitzel, Thomas P. Slavin, Susan M. Domchek, Katherine L. Nathanson, Kristin Zelley, Louise C. Pyle, Suzanne P. MacFarland, Marilyn M. Li, Anh N. Le, Gregory Kelly, Ryan Hausler, Heena Desai, Aaron H. Philips, Andrew V. Kossenkov, Tetyana Martynyuk, Jessica C. Leung, Thibaut Barnoud, Emilia M. Pinto, Jacquelyn Powers
Supplementary Figures 1-4. Supplementary Figure S1: Full Pedigrees from TP53 c.1000G>C;p.G334R clinically ascertained families. Fam ID allows reference to Table 1; Supplementary Figure S2: Constructs encoding p53 wild-type (TP53-WT), p53-R175H (TP53-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c00e89c5b7cf956aea60439d2d5560
https://doi.org/10.1158/0008-5472.22425756
https://doi.org/10.1158/0008-5472.22425756
Autor:
Kara N. Maxwell, Maureen E. Murphy, Raul C. Ribeiro, Gerard P. Zambetti, Richard W. Kriwacki, Sheri L. Spunt, Carolyn Fein Levy, Morris C. Edelman, Brooke Levin, Fergus J. Couch, Kelly McGoldrick, Stephanie Gutierrez, Jill S. Dolinsky, Kenneth Offit, Vijai Joseph, Judy E. Garber, Jill E. Stopfer, Jeffrey N. Weitzel, Thomas P. Slavin, Susan M. Domchek, Katherine L. Nathanson, Kristin Zelley, Louise C. Pyle, Suzanne P. MacFarland, Marilyn M. Li, Anh N. Le, Gregory Kelly, Ryan Hausler, Heena Desai, Aaron H. Philips, Andrew V. Kossenkov, Tetyana Martynyuk, Jessica C. Leung, Thibaut Barnoud, Emilia M. Pinto, Jacquelyn Powers
Germline mutations in TP53 cause a rare high penetrance cancer syndrome, Li–Fraumeni syndrome (LFS). Here, we identified a rare TP53 tetramerization domain missense mutation, c.1000G>C;p.G334R, in a family with multiple late-onset LFS-spectrum canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b22083b0736e430d002f93b84e42e5
https://doi.org/10.1158/0008-5472.c.6512130
https://doi.org/10.1158/0008-5472.c.6512130
Autor:
Sukh Makhnoon, Minxing Chen, Brooke Levin, Megan Ensinger, Kristin Mattie, Generosa Grana, Sanjay Shete, Banu K. Arun, Susan K. Peterson
Publikováno v:
Cancer Research. 83:P6-02
Background: Surveillance is a fundamental tool in the early detection and secondary prevention of many cancers. For women at increased genetic risk of breast cancer, mammography and breast magnetic resonance imaging (MRI) serve as the standard screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e434e3394f8f26698f8e556cafbf19d6
https://doi.org/10.1158/1538-7445.sabcs22-p6-02-04
https://doi.org/10.1158/1538-7445.sabcs22-p6-02-04
Autor:
Erica M. Bednar, Blake Harper, Michael T. Walsh, Ruth Rechis, Michelle Bilbao, Rebecca L. Carr, Amanda L. Eppolito, Timothy Goedde, Brooke Levin, Kristin Mattie, Nichole A. Morman, Kellie Rath, Pauline Russ, Jennifer M. Siettmann, David Warshal, Emaline Wise, Cara Yobbi, Karen H. Lu
Publikováno v:
Journal of genetic counselingREFERENCES.
Program evaluation can identify the successes and challenges of implementing clinical programs, which can inform future dissemination efforts. A cancer genetics improvement program, disseminated from the Lead Team's institution to five health systems
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b58c4ebe47ffa8e0fa6ee6023f7ee6b
https://pubmed.ncbi.nlm.nih.gov/36117454
https://pubmed.ncbi.nlm.nih.gov/36117454
Autor:
Sukh Makhnoon, Brooke Levin, Megan Ensinger, Kristin Mattie, Robert J. Volk, Zhongming Zhao, Tito Mendoza, Sanjay Shete, Laila Samiian, Generosa Grana, Andrew Grainger, Banu Arun, Brian H. Shirts, Susan K. Peterson
Publikováno v:
Cancer medicineREFERENCES.
10512 Background: Up to 10% of all cancers are attributable to germline mutations and identifying mutation carriers is critical for cancer prevention. Clinical interpretation of genetic test results is complicated by variants of uncertain significanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5a731d2e3a106f0b19d23678c50aa4
https://pubmed.ncbi.nlm.nih.gov/36426404
https://pubmed.ncbi.nlm.nih.gov/36426404
Autor:
Stephanie Rivera Morales, Ian Dale, Kristin Mattie, Brooke Levin, Jamin C. Morrison, Jenia Jenab-Wolcott
Publikováno v:
Journal of Clinical Oncology. 40:311-311
311 Background: Despite guidelines recommending germline genetic testing (GT) and genetic counseling for individuals with pancreatic ductal adenocarcinoma (PDAC), referrals remain suboptimal. This can have negative implications on treatment, particul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a9cb7d44e777fb3d2b1f69d7ea4ee38
https://doi.org/10.1200/jco.2022.40.28_suppl.311
https://doi.org/10.1200/jco.2022.40.28_suppl.311