Výsledky vyhledávání - "Brooke L. Brauer"

Evaluation of Quantification and Normalization Strategies for Phosphoprotein Phosphatase Affinity Proteomics: Application to Breast Cancer Signaling

Autor: Brooke L. Brauer, Kwame Wiredu, Scott A. Gerber, Arminja N. Kettenbach

Publikováno v: Journal of Proteome Research. 22:47-61

Accurate quantification of proteomics data is essential for revealing and understanding biological signaling processes. We have recently developed a chemical proteomic strategy termed phosphatase inhibitor beads and mass spectrometry (PIB-MS) to inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3da9e2cc76f0e7aa0a1410f72f5243
https://doi.org/10.1021/acs.jproteome.2c00465

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Affinity-based profiling of endogenous phosphoprotein phosphatases by mass spectrometry

Autor: Greg B. G. Moorhead, Scott A. Gerber, Brooke L. Brauer, Sierra Mitchell, Arminja N. Kettenbach, Kwame Wiredu

Publikováno v: Nat Protoc

Phosphoprotein phosphatases (PPPs) execute >90% of serine/threonine dephosphorylation in cells and tissues. While the role of PPPs in cell biology and diseases such as cancer, cardiac hypertrophy and Alzheimer’s disease is well established, the mol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead33782360b940ccbe530865529eeaf
https://pubmed.ncbi.nlm.nih.gov/34518704

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High estrogen receptor alpha activation confers resistance to estrogen deprivation and is required for therapeutic response to estrogen in breast cancer

Autor: Eugene Demidenko, Jonathan D. Marotti, Nicole A. Traphagen, Todd W. Miller, Amanda Jiang, Brooke L. Brauer, Sarah R. Hosford

Publikováno v: Oncogene

Estrogen receptor alpha (ER)-positive breast cancer is commonly treated with endocrine therapies, including anti-estrogens that bind and inhibit ER activity, and aromatase inhibitors that suppress estrogen biosynthesis to inhibit estrogen-dependent E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37338649d84dfd5d40ac3b15ce796b40
https://pubmed.ncbi.nlm.nih.gov/33875787

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Leveraging New Definitions of the LxVP SLiM To Discover Novel Calcineurin Regulators and Substrates

Autor: Isha Nasa, Brooke L. Brauer, Sarah R. Sheftic, Wolfgang Peti, Thomas M. Moon, Rebecca Page, Arminja N. Kettenbach

Publikováno v: ACS Chem Biol

The Phosphoprotein Phosphatase Calcineurin (CN, PP2B, PP3) recognizes and binds to two short linear motifs (SLiMs), PxIxIT and LxVP, in its regulators and substrates. These interactions enable CN function in many key biological processes. The identif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48467edda21d357d66312d3d97bba466
https://europepmc.org/articles/PMC6925343/

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