Zobrazeno 1 - 10
of 480
pro vyhledávání: '"Brooke L, Fridley"'
Autor:
Oscar E. Ospina, Alex C. Soupir, Roberto Manjarres-Betancur, Guillermo Gonzalez-Calderon, Xiaoqing Yu, Brooke L. Fridley
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Spatial transcriptomics (ST) assays represent a revolution in how the architecture of tissues is studied by allowing for the exploration of cells in their spatial context. A common element in the analysis is delineating tissue domains or “
Externí odkaz:
https://doaj.org/article/ca1fbdbab8a1429098ca963d8e23584c
Autor:
Heming Wang, Brett M. Reid, Rebecca C. Richmond, Jacqueline M. Lane, Richa Saxena, Brian D. Gonzalez, Brooke L. Fridley, Susan Redline, Shelley S. Tworoger, Xuefeng Wang
Publikováno v:
EBioMedicine, Vol 104, Iss , Pp 105175- (2024)
Summary: Background: Insomnia is the most common sleep disorder in patients with epithelial ovarian cancer (EOC). We investigated the causal association between genetically predicted insomnia and EOC risk and survival through a two-sample Mendelian r
Externí odkaz:
https://doaj.org/article/da9992050de84043863a1b99008c02db
Autor:
Darcy L. Welch, Brooke L. Fridley, Ling Cen, Jamie K. Teer, Sean J. Yoder, Fredrik Pettersson, Liping Xu, Chia-Ho Cheng, Yonghong Zhang, Mark G. Alexandrow, Shengyan Xiang, Mark Robertson-Tessi, Joel S. Brown, Jonathan Metts, Andrew S. Brohl, Damon R. Reed
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Osteosarcoma is the most common bone sarcoma in children and young adults. While universally delivered, chemotherapy only benefits roughly half of patients with localized disease. Increasingly, intratumoral heterogeneity is recognized as a s
Externí odkaz:
https://doaj.org/article/f7513fb0926f4a94b84dd06a5b81bbee
Autor:
Naoko Sasamoto, Paul A. Stewart, Tianyi Wang, Zachary J. Thompson, Sean J. Yoder, Jonathan L. Hecht, John L. Cleveland, Jose Conejo‐Garcia, Brooke L. Fridley, Kathryn L. Terry, Shelley S. Tworoger
Publikováno v:
Cancer Medicine, Vol 12, Iss 17, Pp 18405-18417 (2023)
Abstract Background Aspirin use has been associated with reduced ovarian cancer risk, yet the underlying biological mechanisms are not fully understood. To gain mechanistic insights, we assessed the association between prediagnosis low and regular‐
Externí odkaz:
https://doaj.org/article/4e60807f476e4be1828c4fc2a22e7d83
Autor:
Teemu D. Laajala, Varsha Sreekanth, Alex C. Soupir, Jordan H. Creed, Anni S. Halkola, Federico C. F. Calboli, Kalaimathy Singaravelu, Michael V. Orman, Christelle Colin-Leitzinger, Travis Gerke, Brooke L. Fridley, Svitlana Tyekucheva, James C. Costello
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-13 (2023)
Abstract Genomic and transcriptomic data have been generated across a wide range of prostate cancer (PCa) study cohorts. These data can be used to better characterize the molecular features associated with clinical outcomes and to test hypotheses acr
Externí odkaz:
https://doaj.org/article/74d7b11469474de8bb6ff94431c8476f
Autor:
Victoria Walker, Dexter X. Jin, Sherri Z. Millis, Elham Nasri, Diana A. Corao-Uribe, Aik Choon Tan, Brooke L. Fridley, James L. Chen, Nathan D. Seligson
Publikováno v:
Translational Oncology, Vol 38, Iss , Pp 101795- (2023)
EWSR1 fusions are highly promiscuous and are associated with unique malignancies, clinical phenotypes, and molecular subtypes. However, rare fusion partners (RFP) of EWSR1 has not been well described. Here, we conducted a cross-sectional, retrospecti
Externí odkaz:
https://doaj.org/article/ae73193f256f469da6b1e11425a6ff92
Autor:
Jonathan L. Metts, Matteo Trucco, Daniel A. Weiser, Patrick Thompson, Eric Sandler, Tiffany Smith, Jessica Crimella, Samer Sansil, Ram Thapa, Brooke L. Fridley, Nicholas Llosa, Thomas Badgett, Richard Gorlick, Damon Reed, Jonathan Gill
Publikováno v:
Cancer Medicine, Vol 12, Iss 4, Pp 4270-4281 (2023)
Abstract Background Patients with relapsed and refractory solid and central nervous system (CNS) tumors have poor outcomes and need novel therapeutic options. Vincristine, irinotecan, and temozolomide (VIT) is a common chemotherapy regimen in relapse
Externí odkaz:
https://doaj.org/article/819f4342edbb4b839d42f66a42eadf95
Autor:
Naoko Sasamoto, Paul A. Stewart, Tianyi Wang, Sean J. Yoder, Srikumar Chellappan, Jonathan L. Hecht, Brooke L. Fridley, Kathryn L. Terry, Shelley S. Tworoger
Publikováno v:
Journal of Ovarian Research, Vol 15, Iss 1, Pp 1-11 (2022)
Abstract Background Greater ovulatory years is associated with increased ovarian cancer risk. Although ovulation leads to an acute pro-inflammatory local environment, how long-term exposure to ovulation impacts ovarian carcinogenesis is not fully und
Externí odkaz:
https://doaj.org/article/0acf7f99667447359f53e928a404a5fc
Autor:
Melissa Thomas, Junan Li, Kevan King, Avinash K Persaud, Ernest Duah, Zachary Vangundy, Craig C. Hofmeister, Jatinder K. Lamba, Aik Choon Tan, Brooke L. Fridley, Ming J. Poi, Nathan D. Seligson
Publikováno v:
Haematologica, Vol 108, Iss 8 (2023)
Multiple Myeloma (MM) is an incurable plasma cell malignancy often treated by autologous stem cell transplant (ASCT). Clinical response to ASCT has been associated with DNA repair efficiency. Here we interrogated the role of the base excision DNA rep
Externí odkaz:
https://doaj.org/article/7a7b8d3edef349908f93a513689d97de
Autor:
Farnoosh Abbas-Aghababazadeh, Naoko Sasamoto, Mary K. Townsend, Tianyi Huang, Kathryn L. Terry, Allison F. Vitonis, Kevin M. Elias, Elizabeth M. Poole, Jonathan L. Hecht, Shelley S. Tworoger, Brooke L. Fridley
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
ObjectiveOptimal debulking with no macroscopic residual disease strongly predicts ovarian cancer survival. The ability to predict likelihood of optimal debulking, which may be partially dependent on tumor biology, could inform clinical decision-makin
Externí odkaz:
https://doaj.org/article/f58f5bf3c1a74cad896c1c704eef90af