Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Brooke K McMichael"'
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87402 (2014)
Osteoclasts are large, multinucleated cells of the monocyte-macrophage lineage that generate specialized substrate adhesion complexes to facilitate their function as bone-degrading cells. The patterning and function of these actin-based complexes, po
Externí odkaz:
https://doaj.org/article/a64e5b61cc134caea953b2dcc20d98be
Autor:
Reeva Aggarwal, Jingwei Lu, Suman Kanji, Matthew Joseph, Manjusri Das, Garrett J Noble, Brooke K McMichael, Sudha Agarwal, Richard T Hart, Zongyang Sun, Beth S Lee, Thomas J Rosol, Rebecca Jackson, Hai-Quan Mao, Vincent J Pompili, Hiranmoy Das
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39365 (2012)
Osteoporosis is a bone disorder associated with loss of bone mineral density and micro architecture. A balance of osteoblasts and osteoclasts activities maintains bone homeostasis. Increased bone loss due to increased osteoclast and decreased osteobl
Externí odkaz:
https://doaj.org/article/9dc52b2d97a744c4b519d68f6ef9356c
Autor:
Yong-Hoon Jeong, Beth S. Lee, Brooke K. McMichael, Martin Bähler, Kyle Bodnyk, Do-Gyoon Kim, Ryan Sedlar
Publikováno v:
Journal of the Mechanical Behavior of Biomedical Materials. 84:99-107
The objective of this study was to examine relationships among a variety of bone characteristics, including volumetric, mineral density, geometric, dynamic mechanical analysis, and static fracture mechanical properties. As MYO9B is an unconventional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c79707f2e9e2507163aeb8cead311c
https://doi.org/10.1016/j.jmbbm.2018.05.003
https://doi.org/10.1016/j.jmbbm.2018.05.003
Autor:
Beth S. Lee, Brooke K. McMichael, Ryan Sedlar, Justin A Auerbach, Do-Gyoon Kim, Sudha Agarwal, Martin Bähler, Yong-Hoon Jeong, Cheol-Min Han, Vikram Shettigar
Publikováno v:
Journal of Bone and Mineral Research. 32:2103-2115
The Ras homolog A (RhoA) subfamily of Rho guanosine triphosphatases (GTPases) regulates actin-based cellular functions in bone such as differentiation, migration, and mechanotransduction. Polymorphisms or genetic ablation of RHOA and some of its regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a17e1124887b9a020fb3cc7380c70503
https://doi.org/10.1002/jbmr.3192
https://doi.org/10.1002/jbmr.3192
Autor:
Brooke K, McMichael, Yong-Hoon, Jeong, Justin A, Auerbach, Cheol-Min, Han, Ryan, Sedlar, Vikram, Shettigar, Martin, Bähler, Sudha, Agarwal, Do-Gyoon, Kim, Beth S, Lee
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 32(10)
The Ras homolog A (RhoA) subfamily of Rho guanosine triphosphatases (GTPases) regulates actin-based cellular functions in bone such as differentiation, migration, and mechanotransduction. Polymorphisms or genetic ablation of RHOA and some of its regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b39fde698244a7d9204125c6bfa69e09
https://pubmed.ncbi.nlm.nih.gov/28585695
https://pubmed.ncbi.nlm.nih.gov/28585695
Autor:
Jingwei Lu, Brooke K. McMichael, Sudha Agarwal, Manjusri Das, Periannan Kuppusamy, Beth S. Lee, A. Ray-Chaudhury, Obiajulu H. Iwenofu, Vincent J. Pompili, Hiranmoy Das, Mukesh K. Jain, Matthew Joseph, Reeva Aggarwal, Suman Kanji
Publikováno v:
Current Molecular Medicine. 12:113-125
Kruppel-like factor 2 (KLF2) plays an important role in the regulation of a variety of immune cells, including monocytes. We have previously shown that KLF2 inhibits proinflammatory activation of monocytes. However, the role of KLF2 in arthritis is y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed47ae0328cff269d06c8f7a440c5255
https://doi.org/10.2174/156652412798889090
https://doi.org/10.2174/156652412798889090
Publikováno v:
Journal of Biological Chemistry. 285:26641-26651
Osteoclasts resorb bone through the formation of a unique attachment structure called the sealing zone. In this study, a role for thyroid hormone receptor-interacting protein 6 (TRIP6) in sealing zone formation and osteoclast activity was examined. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428d62f05d73d96512b09f83fa7d1bc7
https://doi.org/10.1074/jbc.m110.119909
https://doi.org/10.1074/jbc.m110.119909
Publikováno v:
Journal of Biological Chemistry. 285:9506-9515
Osteoclasts use actin-rich attachment structures in place of focal adhesions for adherence to bone and non-bone substrates. On glass, osteoclasts generate podosomes, foot-like processes containing a core of F-actin and regulatory proteins that underg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7eb294f2e58c8fdf14ecbfe15836ba
https://doi.org/10.1074/jbc.m109.017269
https://doi.org/10.1074/jbc.m109.017269
Autor:
Brooke K. McMichael, Beth S. Lee
Publikováno v:
Experimental Cell Research. 314:564-573
Tropomyosins (Tms) are alpha-helical dimers that bind and stabilize actin microfilaments while regulating their accessibility to other actin-associated proteins. Four genes encode expression of over forty Tms, most of which are expressed in nonmuscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b7ca8adaceb5bdd8ea2f7aa45d44554
https://doi.org/10.1016/j.yexcr.2007.10.018
https://doi.org/10.1016/j.yexcr.2007.10.018
Autor:
Brooke K. McMichael, Beth S. Lee
Publikováno v:
The Cytoskeleton in Health and Disease ISBN: 9781493929030
As products of cell–cell fusion and as highly mobile, bone-degrading cells, osteoclasts require a unique, abundantly adaptable actin cytoskeleton. This chapter summarizes the current understanding of osteoclast cytoskeletal dynamics with particular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdcee330ba431b1aaef075bb9b390434
https://doi.org/10.1007/978-1-4939-2904-7_14
https://doi.org/10.1007/978-1-4939-2904-7_14
