Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Brooke E Shaner"'
Autor:
Midhun C Korrapati, Lauren A Howell, Brooke E Shaner, Judit K Megyesi, Leah J Siskind, Rick G Schnellmann
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73655 (2013)
To determine whether delayed administration of a single dose of suramin, a drug that has been used extensively in humans to treat trypanosomiasis, attenuates renal injury in a leptin receptor deficient C57BLKS/J db/db type 2 diabetic nephropathy (T2D
Externí odkaz:
https://doaj.org/article/89bd3183f4a34945ade783ba141ee564
Publikováno v:
The Open Medicinal Chemistry Journal
Kappa-opioid agonists are particularly efficacious in the treatment of peripheral pain but suffer from central nervous system (CNS)-mediated effects that limit their development. One promising kappa-agonist is the peptidic compound CR665. Although no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239c512cebd6f319b5d35a3a1b0e6fbd
https://doi.org/10.2174/1874104501307010016
https://doi.org/10.2174/1874104501307010016
Autor:
James G. Kennis, Danielle W. Lowe, J. Todd Purves, Melissa N Youssef, Francis M. Hughes, Brooke E. Shaner
Publikováno v:
Journal of Clinical & Cellular Immunology.
Objective: NOD-like receptors (NLRs) sense sterile and non-sterile signals and form inflammasomes which trigger an inflammatory response through the activation of caspase-1 and release of IL-1β. Recently we have shown the presence of several NLRs in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07913c1ff5f9c51a88bdbfe03633bdc0
https://doi.org/10.4172/2155-9899.1000396
https://doi.org/10.4172/2155-9899.1000396
Autor:
Paul J. Nietert, Jeffery D. Pratt-Thomas, J. Purves, James G. Kennis, Monty Hughes, Danielle W. Lowe, Laura Spruill, Brooke E. Shaner, Nivardo P. Vivar
Publikováno v:
Journal of Urology. 191
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::add56df252c1a012afa92e24ec6d6d04
https://doi.org/10.1016/j.juro.2014.02.358
https://doi.org/10.1016/j.juro.2014.02.358
Autor:
Jeffery D. Pratt-Thomas, Francis M. Hughes, J. Todd Purves, Nivardo P. Vivar, Brooke E. Shaner, Paul J. Nietert, Danielle W. Lowe, Laura Spruill, James G. Kennis
Bladder inflammation (cystitis) underlies numerous bladder pathologies and is elicited by a plethora of agents such as urinary tract infections, bladder outlet obstruction, chemotherapies, and catheters. Pattern recognition receptors [Toll-like recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9f814094756f7cacf367cd99b12345
https://europepmc.org/articles/PMC4073918/
https://europepmc.org/articles/PMC4073918/
Autor:
Joseph L. Alge, Rick G. Schnellmann, Midhun C. Korrapati, Benjamin A. Neely, Brooke E. Shaner, John M. Arthur
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 343(1)
Progression of hyperglycemia-induced renal injury is a contributing factor for diabetic nephropathy (DN)-induced end-stage renal disease (ESRD), and development of novel therapeutic strategies that act early to prevent progression of DN and ESRD are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6983165f1b55fe9260eeac1cb3d95e8d
https://pubmed.ncbi.nlm.nih.gov/22736507
https://pubmed.ncbi.nlm.nih.gov/22736507
Acute kidney injury (AKI) is a common and potentially life-threatening complication after ischemia/reperfusion and exposure to nephrotoxic agents. In this study, we examined the efficacy and mechanism(s) of suramin in promoting recovery from glycerol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4205e4e5fa6be95224ccda8ce1372b1f
https://europepmc.org/articles/PMC3310704/
https://europepmc.org/articles/PMC3310704/
Autor:
Michael Cash, Francis M. Hughes, Brooke E. Shaner, Thomas A. Dix, Jean Mazella, Dustin Morrow, Lisa A. May, Fabienne Massa, Lyndsay Zotian, Justin O. Brower, R. Jeremy Woods
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2010, 53 (12), pp.4623-32. ⟨10.1021/jm100092s⟩
Journal of Medicinal Chemistry, American Chemical Society, 2010, 53 (12), pp.4623-32. ⟨10.1021/jm100092s⟩
International audience; The neurotensin hexapapetide fragment NT(8-13) is a potent analgesic when administered directly to the central nervous system but does not cross the blood-brain barrier. A total of 43 novel derivatives of NT(8-13) were evaluat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa0e873d0a51ee987b140be0faf674c
https://hal.archives-ouvertes.fr/hal-00498785
https://hal.archives-ouvertes.fr/hal-00498785