To Approach or Avoid: An Introductory Overview of the Study of Anxiety Using Rodent Assays

Autor: Mimi La-Vu, Brooke C. Tobias, Peter J. Schuette, Avishek Adhikari

Publikováno v: Frontiers in Behavioral Neuroscience, Vol 14 (2020)

Anxiety is a widely studied phenomenon in behavioral neuroscience, but the recent literature lacks an overview of the major conceptual framework underlying anxiety research to introduce young researchers to the field. In this mini-review article, whi

Externí odkaz: https://doaj.org/article/3bebe2b236d24bf0b6be59c191b656fb

Author response for 'Characterization of ventromedial hypothalamus activity during exposure to innate and conditioned threats'

Autor: null Brooke C. Tobias, null Peter J. Schuette, null Sandra Maesta‐Pereira, null Anita Torossian, null Weisheng Wang, null Ekayana Sethi, null Avishek Adhikari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b71ae7b39e3fd4e60d6cd0a19cbe2a
https://doi.org/10.1111/ejn.15937/v3/response1

Sparse genetically defined neurons refine the canonical role of periaqueductal gray columnar organization

Autor: Mimi Q La-Vu, Ekayana Sethi, Sandra Maesta-Pereira, Peter J Schuette, Brooke C Tobias, Fernando MCV Reis, Weisheng Wang, Anita Torossian, Amy Bishop, Saskia J Leonard, Lilly Lin, Catherine M Cahill, Avishek Adhikari

Publikováno v: eLife. 11

During threat exposure, survival depends on defensive reactions. Prior works linked large glutamatergic populations in the midbrain periaqueductal gray (PAG) to defensive freezing and flight, and established that the overarching functional organizati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36195c4667fad4a870f48464cefcf30f
https://pubmed.ncbi.nlm.nih.gov/35674316

Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats

Autor: Jonathan C. Kao, Megha Sehgal, Sandra Maesta-Pereira, Weisheng Wang, Fernando Midea Cuccovia V. Reis, Meghmik Chakerian, Alcino J. Silva, Peter J Schuette, Tor D. Wager, Marta Ceko, Avishek Adhikari, Mimi Q La-Vu, Newton S. Canteras, Philip A. Kragel, Shiyu Ji, Brooke C Tobias

Escape from threats has paramount importance for survival. However, it is unknown if a single circuit controls escape from innate and conditioned threats. The hypothalamic dorsal premammillary nucleus (PMd) may control escape, as it is activated by e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::486353e4fb0bdb0d5418b744227b56bb
https://doi.org/10.1101/2021.05.02.442354

Dorsal periaqueductal gray ensembles represent approach and avoidance states

Autor: Mimi Q La-Vu, Juliane Midori Ikebara, Peter J Schuette, Alexandre Hiroaki Kihara, Fernando M. C. V. Reis, Sandra Maesta-Pereira, Meghmik Chakerian, Newton S. Canteras, Brooke C Tobias, Jinhan Liu, Avishek Adhikari, Johannes Y Lee, Jonathan C. Kao

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
eLife, Vol 10 (2021)
eLife

Animals must balance needs to approach threats for risk assessment and to avoid danger. The dorsal periaqueductal gray (dPAG) controls defensive behaviors, but it is unknown how it represents states associated with threat approach and avoidance. We i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090f239e0127f08ee6d7cfa04b4930aa