Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Brooke A. Keating"'
Autor:
Erica Tsang, Velda X. Han, Chloe Flutter, Sarah Alshammery, Brooke A. Keating, Tracey Williams, Brian S. Gloss, Mark E. Graham, Nader Aryamanesh, Ignatius Pang, Melanie Wong, David Winlaw, Michael Cardamone, Shekeeb Mohammad, Wendy Gold, Shrujna Patel, Russell C. Dale
Publikováno v:
EBioMedicine, Vol 104, Iss , Pp 105156- (2024)
Summary: Background: Kabuki syndrome (KS) is a genetic disorder caused by DNA mutations in KMT2D, a lysine methyltransferase that methylates histones and other proteins, and therefore modifies chromatin structure and subsequent gene expression. Keton
Externí odkaz:
https://doaj.org/article/706dcecdfb3d41058e9433023d709cb7
Autor:
Jingya Yan, Kavitha Kothur, Shekeeb Mohammad, Jason Chung, Shrujna Patel, Hannah F. Jones, Brooke A. Keating, Velda X. Han, Richard Webster, Simone Ardern-Holmes, Jayne Antony, Manoj P. Menezes, Esther Tantsis, Deepak Gill, Sachin Gupta, Tejaswi Kandula, Hugo Sampaio, Michelle A. Farrar, Christopher Troedson, P Ian Andrews, Sekhar C. Pillai, Benjamin Heng, Gilles J. Guillemin, Anna Guller, Sushil Bandodkar, Russell C. Dale
Publikováno v:
EBioMedicine, Vol 91, Iss , Pp 104589- (2023)
Summary: Background: Defining the presence of acute and chronic brain inflammation remains a challenge to clinicians due to the heterogeneity of clinical presentations and aetiologies. However, defining the presence of neuroinflammation, and monitori
Externí odkaz:
https://doaj.org/article/f3f98b36f0cb49b9aa7418bacef1fbf5
Publikováno v:
Cells, Vol 12, Iss 18, p 2317 (2023)
Immune cells play a critical role in promoting neuroinflammation and the development of neuropathic pain. However, some subsets of immune cells are essential for pain resolution. Among them are regulatory T cells (Tregs), a specialised subpopulation
Externí odkaz:
https://doaj.org/article/9879462ba99d4103bb05a0f9402ac82d
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2023)
Mental health and neurodevelopmental disorders are extremely common across the lifespan and are characterized by a complicated range of symptoms that affect wellbeing. There are relatively few drugs available that target disease mechanisms for any of
Externí odkaz:
https://doaj.org/article/5c6b64a4cc094bc593e4a27bad65cbe0
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Externí odkaz:
https://doaj.org/article/edb54ad889934608b81b3f8ec06cc4f6
Autor:
Justin G Lees, Daniel White, Brooke A Keating, Mallory E Barkl-Luke, Preet G S Makker, David Goldstein, Gila Moalem-Taylor
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238164 (2020)
PurposeHaematological toxicities occur in patients receiving oxaliplatin. Mild anaemia (grade 1-2) is a common side effect and approximately 90% of recipients develop measurable spleen enlargement. Although generally asymptomatic, oxaliplatin-induced
Externí odkaz:
https://doaj.org/article/974eafa037e34cfeae0f803eb15d15f8
Autor:
Susanna B. Park, David Goldstein, Nathan T Fiore, Justin G. Lees, Mallory E. Barkl-Luke, Lital Livni, Brooke A Keating, Munawwar Abdulla, Jessica P. Hayes, Gila Moalem-Taylor
Publikováno v:
Muscle & Nerve. 64:225-234
INTRODUCTION/AIMS Clinically, the chemotherapeutic agent oxaliplatin can cause peripheral neuropathy, impaired balance, and muscle wastage. Using a preclinical model, we investigated whether exercise intervention could improve these adverse condition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27995d016c130f2ceface02bffc7a6e
https://doi.org/10.1002/mus.27329
https://doi.org/10.1002/mus.27329
Autor:
Preet G.S. Makker, James Howells, Justin G. Lees, Brooke A Keating, Gila Moalem-Taylor, David Burke
Publikováno v:
Journal of the Peripheral Nervous System. 26:99-112
Peripheral nerve injuries caused by focal constriction are characterised by local nerve ischaemia, axonal degeneration, demyelination, and neuroinflammation. The aim of this study was to understand temporal changes in the excitability properties of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e67a6c6957acb0ea055c75eeabbdac6
https://doi.org/10.1111/jns.12430
https://doi.org/10.1111/jns.12430
Autor:
Pascal Carrive, Samuel S. Duffy, Oleg Butovsky, Gila Moalem-Taylor, Preet G.S. Makker, Ryan S. Tonkin, Brooke A Keating, Justin G. Lees, Chamini J. Perera
Publikováno v:
The Journal of Neuroscience. 39:2326-2346
Sensory problems such as neuropathic pain are common and debilitating symptoms in multiple sclerosis (MS), an autoimmune inflammatory disorder of the CNS. Regulatory T (Treg) cells are critical for maintaining immune homeostasis, but their role in MS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2c609efa868fdb43dadb1d036f2ebd
https://doi.org/10.1523/jneurosci.1815-18.2019
https://doi.org/10.1523/jneurosci.1815-18.2019
Autor:
Brooke A Keating, David Goldstein, Nathan T Fiore, Gila Moalem-Taylor, Justin G. Lees, Lital Livni
Publikováno v:
Pain. 163(1)
A modern approach for cancer treatment is the use of immunotherapy, and particularly immune checkpoint inhibitors, such as anti-programmed cell death protein 1 (PD-1), alone and in combination with chemotherapy. The PD-1 pathway plays a crucial role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8678551ae60ffd4db565b7fb50b8ad
https://pubmed.ncbi.nlm.nih.gov/34224494
https://pubmed.ncbi.nlm.nih.gov/34224494