Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Brooke A, Furlong"'
Autor:
David B. Chou, Brooke A. Furlong, Ryan R. Posey, Christos Kyprianou, Lucy R. O’Sullivan, Rhiannon David, Suzanne J. Randle, Urszula M. Polanska, Jon Travers, Jelena Urosevic, John N. Hutchinson, Jianwei Che, Anna M. Howley, Robert P. Hasserjian, Rachelle Prantil-Baun, Donald E. Ingber
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Patients treated with Aurora kinase inhibitors experience dose-limiting neutropenia while other cytopenias are rare. Here, Chou et al. show that this cell-type specific side effect is partly explained by loss of drug efflux pump expression during neu
Externí odkaz:
https://doaj.org/article/30b138eaa22049aea33459bc0a7f87f2
Autor:
James Logue, Arup R. Chakraborty, Robert Johnson, Girija Goyal, Melissa Rodas, Louis J. Taylor, Lauren Baracco, Marisa E. McGrath, Robert Haupt, Brooke A. Furlong, Mercy Soong, Pranav Prabhala, Viktor Horvath, Kenneth E. Carlson, Stuart Weston, Donald E. Ingber, Melvin L. DePamphilis, Matthew B. Frieman
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)
Compound-testing in a murine model for COVID-19 show that the prophylactic or therapeutic application of Apilimod and other PIKfyve inhibitors, the former being considered for human Phase II trials, worsens disease outcome with higher lung viral load
Externí odkaz:
https://doaj.org/article/9de19b41ea5f445cb565a156c6a567d3
Autor:
James Logue, Arup R. Chakraborty, Robert Johnson, Girija Goyal, Louis J. Taylor, Lauren Baracco, Marisa E. McGrath, Robert Haupt, Melissa Rodas, Brooke A. Furlong, Mercy Soong, Pranav Prabhala, Viktor Horvath, Kenneth E. Carlson, Stuart Weston, Donald E. Ingber, Melvin L. DePamphilis, Matthew B. Frieman
The ongoing COVID-19 pandemic has claimed more than 6 million lives and continues to test the world economy and healthcare systems. To combat this pandemic, the biological research community has shifted efforts to the development of medical counterme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66c0b407f9cfce5cffaed88bdf9aece6
https://doi.org/10.21203/rs.3.rs-1605065/v1
https://doi.org/10.21203/rs.3.rs-1605065/v1
Autor:
Petar Pop-Damkov, Rhiannon David, Arianna Rech, Lucy R. O’Sullivan, Susan Marquez, Brooke A. Furlong, Douglas Ferguson, Kasiani C. Myers, Amanda Jiang, Liliana Moreira Teixeira, Oren Levy, Youngjae Choe, Özge Vargel Bölükbaşı, David B. Chou, Richard M. Novak, Olga K. Weinberg, Carl D. Novina, Robert P. Hasserjian, Lorna Ewart, Yuka Milton, Cailin E. Joyce, Viktoras Frismantas, Elizabeth Calamari, Sasan Jalili-Firoozinezhad, Rachelle Prantil-Baun, Donald E. Ingber, Alexander MacDonald, Akiko Shimamura, Carlos F. Ng
Publikováno v:
Nature biomedical engineering
The inaccessibility of living bone marrow (BM) hampers the study of its pathophysiology under myelotoxic stress induced by drugs, radiation or genetic mutations. Here, we show that a vascularized human BM-on-a-chip (BM chip) supports the differentiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66cf03e68d0e18e8f71c4d35cda6d0e2
http://europepmc.org/articles/PMC7160021
http://europepmc.org/articles/PMC7160021
Autor:
Suzanne Randle, Donald E. Ingber, John W. Hutchinson, Jon Travers, Robert P. Hasserjian, Rachelle Prantil-Baun, Brooke A. Furlong, Ryan R. Posey, David B. Chou, Jelena Urosevic, Christos Kyprianou, Urszula M. Polanska, Rhiannon David, Lucy R. O’Sullivan
Publikováno v:
Blood. 138:4292-4292
Chemotherapy-induced cytopenias are a prevalent and significant issue that worsens clinical outcomes and hinders the effective treatment of cancer. While they are classically associated with traditional cytotoxic chemotherapies, they also occur with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e17a5149dd40086196c6603259d67e6e
https://doi.org/10.1182/blood-2021-153422
https://doi.org/10.1182/blood-2021-153422
Autor:
Richard M. Novak, Viktoras Frismantas, Donald E. Ingber, Rhiannon David, Olga K. Weinberg, Arianna Rech, Robert P. Hasserjian, Sasan Jalili-Firoozinezhad, Susan Marquez, Elizabeth Calamari, Lucy R. O’Sullivan, Lorna Ewart, Youngjae Choe, Carl D. Novina, Amanda Jiang, Özge Vargel Bölükbaşı, Yuka Milton, Liliana Moreira Teixeira, Petar Pop-Damkov, Oren Levy, Brooke A. Furlong, David B. Chou, Rachelle Prantil-Baun, Douglas Ferguson, Carlos F. Ng, Cailin E. Joyce, Akiko Shimamura, Alexander MacDonald, Kasiani C. Myers
Publikováno v:
Nature Biomedical Engineering. 4:477-477
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::221420ff843982003c4f78b3c2465f9d
https://doi.org/10.1038/s41551-020-0529-6
https://doi.org/10.1038/s41551-020-0529-6
Autor:
David B, Chou, Viktoras, Frismantas, Yuka, Milton, Rhiannon, David, Petar, Pop-Damkov, Douglas, Ferguson, Alexander, MacDonald, Özge, Vargel Bölükbaşı, Cailin E, Joyce, Liliana S, Moreira Teixeira, Arianna, Rech, Amanda, Jiang, Elizabeth, Calamari, Sasan, Jalili-Firoozinezhad, Brooke A, Furlong, Lucy R, O'Sullivan, Carlos F, Ng, Youngjae, Choe, Susan, Marquez, Kasiani C, Myers, Olga K, Weinberg, Robert P, Hasserjian, Richard, Novak, Oren, Levy, Rachelle, Prantil-Baun, Carl D, Novina, Akiko, Shimamura, Lorna, Ewart, Donald E, Ingber
Publikováno v:
Nature biomedical engineering. 4(4)
The inaccessibility of living bone marrow (BM) hampers the study of its pathophysiology under myelotoxic stress induced by drugs, radiation or genetic mutations. Here, we show that a vascularized human BM-on-a-chip (BM chip) supports the differentiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6d2a85e035f2f84beeeb22fcf2ce3dde
https://pubmed.ncbi.nlm.nih.gov/32286508
https://pubmed.ncbi.nlm.nih.gov/32286508