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Akademický článek

End-to-end donor screening and manufacturing controls: complementary quality-based strategies to minimize patient risk for donor-derived microbiome therapeutics

Autor: Jason Goldsmith, Sarah Tomkovich, John G. Auniņš, Barbara H. McGovern, Jennifer C. Mahoney, Brooke R. Hasson, Christopher W J McChalicher, David S. Ege

Publikováno v: Gut Microbes, Vol 16, Iss 1 (2024)

Advances in microbiome therapeutics have been motivated by a deeper understanding of the role that the gastrointestinal microbiome plays in human health and disease. The FDA approval of two stool-derived live biotherapeutic products (LBPs), REBYOTA®

Externí odkaz: https://doaj.org/article/d50c2aaf0d6047ffbd335412cd5b848c

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Akademický článek

Integrated Safety and Efficacy Analyses of Phase 3 Trials of a Microbiome Therapeutic for Recurrent CDI

Publikováno v: Infectious Diseases and Therapy, Vol 13, Iss 10, Pp 2105-2121 (2024)

Abstract Introduction Recurrent Clostridioides difficile infection (rCDI) often occurs after standard-of-care antibiotics. VOWST oral spores (VOS, previously SER-109), an FDA-approved orally administered microbiome therapeutic, is indicated to preven

Externí odkaz: https://doaj.org/article/ba87c7a699914c4c8d06cf93ba025fb8

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Prenatal Alcohol Exposure and Transient Systemic Hypoxia–Ischemia Result in Subtle Alterations in Dendritic Complexity in Medial Frontal Cortical Neurons in Juvenile and Young Adult Rat Offspring in a Pilot Study

Autor: Zarena M. Dominguez, Suzy Davies, Nathaniel G. Pavlik, Jessie C. Newville, Brooke R. Hafer, Clement P. Jose, Jessica Gross, Roberto N. Almeida Mancero, Lauren L. Jantzie, Daniel D. Savage, Jessie R. Maxwell

Publikováno v: Cells, Vol 13, Iss 23, p 1983 (2024)

Prenatal alcohol exposure (PAE) is associated with long-term neurodevelopmental deficits resulting in impaired executive functioning and motor control. Intriguingly, PAE has been linked with an increased risk of transient systemic hypoxia–ischemia

Externí odkaz: https://doaj.org/article/0aeba7ffb4304b55a068d66d9825e383

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Akademický článek

Correction to: Integrated Safety and Efficacy Analyses of Phase 3 Trials of a Microbiome Therapeutic for Recurrent CDI

Publikováno v: Infectious Diseases and Therapy, Vol 13, Iss 10, Pp 2209-2210 (2024)

Externí odkaz: https://doaj.org/article/f16a0014b1ca4cc2a94f3e0768a3e630

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Akademický článek

Influence of Pasture Stocking Method on Surface Runoff and Nutrient Loss in the US Upper Midwest

Autor: Eric O. Young, Jessica F. Sherman, Brooke R. Bembeneck, Randall D. Jackson, Jason S. Cavadini, Matthew S. Akins

Publikováno v: Nitrogen, Vol 4, Iss 4, Pp 350-368 (2023)

Grazing and hay forage crops reduce erosion compared to annual crops, but few studies have compared soil and nutrient loss among grazing systems compared to a control. We evaluated runoff water quality and nutrient loss among three grazing systems an

Externí odkaz: https://doaj.org/article/3a4dd30d1e7e4ead913bc4ce31855394

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Akademický článek

Modeling gut neuro-epithelial connections in a novel microfluidic device

Autor: Jose M. de Hoyos-Vega, Xi Yu, Alan M. Gonzalez-Suarez, Sisi Chen, Arnaldo Mercado-Perez, Eugene Krueger, Jeric Hernandez, Yaroslav Fedyshyn, Brooke R. Druliner, David R. Linden, Arthur Beyder, Alexander Revzin

Publikováno v: Microsystems & Nanoengineering, Vol 9, Iss 1, Pp 1-12 (2023)

Abstract The intestinal lumen is filled with diverse chemical and physical stimuli. Intestinal epithelial cells sense these stimuli and signal to enteric neurons which coordinate a range of physiologic processes required for normal digestive tract fu

Externí odkaz: https://doaj.org/article/8988d01fb51a42e7bd786a15be570271

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