Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Brook Brouha"'
1
Non-Invasive Detection of Genomic Atypia Increases Real-World NPV and PPV of the Melanoma Diagnostic Pathway and Reduces Biopsy Burden
Autor: Loren Clarke, Jim Rock, Brook Brouha, Maral Skelsey, Burkhard Jansen, Michael D. Howell, Gary L. Peck
Publikováno v: SKIN The Journal of Cutaneous Medicine. 5:512-523
Background: Management of pigmented lesions currently relies on visual assessment with surgical biopsy and histopathologic examination for those lesions suspicious for melanoma. A non-invasive genomic assay that detects two melanoma-associated biomar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c74c502567de4bc77d6f3e24e44f764
https://doi.org/10.25251/skin.5.5.9
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2
Genomic Atypia to Enrich Melanoma Positivity in Biopsied Lesions: Gene Expression and Pathology Findings From a Large U.S. Registry Study
Autor: Anh Nguyen, Michael D. Howell, Gary L. Peck, Maral K Skelsey, Laura K. Ferris, Jim Rock, Burkhard Jansen, Clay J. Cockerell, Zuxu Yao, Brook Brouha
Publikováno v: SKIN The Journal of Cutaneous Medicine. 5:13-18
Importance: Melanoma is diagnosed in approximately 200,000 people within the US each year and is responsible for more than 6,850 deaths. Currently, clinical suspicion guides biopsy decisions and melanoma is confirmed in approximately 4% of biopsied l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ee43f0921d6ea58cf32df31b9750b1b
https://doi.org/10.25251/skin.5.1.3
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7
The human L1 promoter: Variable transcription initiation sites and a major impact of upstream flanking sequence on promoter activity
Autor: Jens Mayer, Laurence Lavie, Eckart Meese, Esther Maldener, Brook Brouha
Publikováno v: Genome Research. 14:2253-2260
The human genome harbors ∼17% of so-called long interspersed elements (LINEs), or L1, the vast majority of which are 5′-truncated. Full-length 6-kb elements consist of an untranslated 5′-UTR that harbors a promoter, followed by two nonoverlappi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90899924748b0343a718d0943c4d86b3
https://doi.org/10.1101/gr.2745804
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8
Hot L1s account for the bulk of retrotransposition in the human population
Autor: Brook Brouha, Joshua Schustak, Alexander H. Farley, John V. Moran, Haig H. Kazazian, Sheila Lutz-Prigge, Richard M. Badge
Publikováno v: Proceedings of the National Academy of Sciences. 100:5280-5285
Although LINE-1 (long interspersed nucleotide element-1, L1) retrotransposons comprise 17% of the human genome, an exhaustive search of the December 2001 “freeze” of the haploid human genome working draft sequence (95% complete) yielded only 90 L
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a3b96bed8582098f8e983c13078e4c5
https://doi.org/10.1073/pnas.0831042100
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9
Evidence consistent with human L1 retrotransposition in maternal meiosis I
Autor: Christof Meischl, Yue Zhang, Dirk Roos, Eric M. Ostertag, Martin de Boer, Haig H. Kazazian, Herman J. Neijens, Brook Brouha
Publikováno v: American Journal of Human Genetics, 71, 327-336. Cell Press
American journal of human genetics, 71(2), 327-336. Cell Press
We have used a unique polymorphic 3' transduction to show that a human L1, or LINE-1 ((l) under bar ong (i) under bar nterspersed (n) under bar ucleotide (e) under bar lement-1), retrotransposition event most likely occurred in the maternal primary o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a440b047bfb5b5383b8d69e0d26170
https://doi.org/10.1086/341722
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