Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Bronwyn M. Kivell"'
Autor:
Ross van de Wetering, Amy Ewald, Susan Welsh, Lindsay Kornberger, Samuel E. Williamson, Bryan D. McElroy, Eduardo R. Butelman, Thomas E. Prisinzano, Bronwyn M. Kivell
Publikováno v:
Molecules, Vol 28, Iss 12, p 4848 (2023)
Kappa opioid receptor (KOR) agonists have preclinical antipsychostimulant effects; however, adverse side effects have limited their therapeutic development. In this preclinical study, conducted in Sprague Dawley rats, B6-SJL mice, and non-human prima
Externí odkaz:
https://doaj.org/article/54b17a5470e048c9ae4d03998c440fe7
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Kappa-opioid receptors (KOR) are widely expressed throughout the central nervous system, where they modulate a range of physiological processes depending on their location, including stress, mood, reward, pain, inflammation, and remyelination. Howeve
Externí odkaz:
https://doaj.org/article/6e3554946b234bf2b3d93be250527002
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Chemotherapy-induced neuropathic pain is a common side effect for cancer patients which has limited effective treatment options. Kappa opioid receptor (KOR) agonists are a promising alternative to currently available opioid drugs due to their low abu
Externí odkaz:
https://doaj.org/article/97d79a71d1e943a19ad6b16a219e6b6f
Autor:
Kelly F. Paton, Katharina Robichon, Nikki Templeton, Lisa Denny, Afnan Al Abadey, Dan Luo, Thomas E. Prisinzano, Anne C. La Flamme, Bronwyn M. Kivell
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Multiple sclerosis is a neurodegenerative disease associated with demyelination and neuroinflammation in the central nervous system. There is an urgent need to develop remyelinating therapies to better treat multiple sclerosis and other demyelinating
Externí odkaz:
https://doaj.org/article/39b6ddc719c14ca4983202a608459a81
Publikováno v:
Brain Sciences, Vol 12, Iss 12, p 1687 (2022)
Multiple sclerosis is an autoimmune disease characterised by demyelination in the central nervous system. The cuprizone-induced demyelination model is often used in mice to test novel treatments for multiple sclerosis. However, despite significant de
Externí odkaz:
https://doaj.org/article/bd9ea3cf9e564ff094ec2e868e086c14
Autor:
Kelly F. Paton, Andrew Biggerstaff, Sophia Kaska, Rachel S. Crowley, Anne C. La Flamme, Thomas E. Prisinzano, Bronwyn M. Kivell
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
In the search for safer, non-addictive analgesics, kappa opioid receptor (KOPr) agonists are a potential target, as unlike mu-opioid analgesics, they do not have abuse potential. Salvinorin A (SalA) is a potent and selective KOPr agonist, however, cl
Externí odkaz:
https://doaj.org/article/b9f4351e6b5d472db7d619fb7f810bd9
Publikováno v:
Australian and New Zealand Journal of Public Health, Vol 41, Iss 1, Pp 92-98 (2017)
Abstract Objective: To compare changes in smoking habit and psychological addiction in Māori/Pacific and NZ European smokers in response to two annual excise tax increases from 2012 to 2014. Methods: Smokers from New Zealand cities completed questio
Externí odkaz:
https://doaj.org/article/0c0a2e3460214b4399d38fa5be55c116
Autor:
Bronwyn M. Kivell, Kelly F. Paton, Nitin Kumar, Aashish S. Morani, Aimee Culverhouse, Amy Shepherd, Susan A. Welsh, Andrew Biggerstaff, Rachel S. Crowley, Thomas E. Prisinzano
Publikováno v:
Molecules, Vol 23, Iss 10, p 2602 (2018)
The acute activation of kappa opioid receptors (KOPr) produces antinociceptive and anti-cocaine effects, however, their side-effects have limited further clinical development. Mesyl Sal B is a potent and selective KOPr analogue of Salvinorin A (Sal A
Externí odkaz:
https://doaj.org/article/b7c703a3687e4e638f6d6d30eadc40f1
Autor:
Katharina Robichon, Rabia Bibi, Mackenzie Kiernan, Lisa Denny, Thomas E Prisinzano, Bronwyn M Kivell, Anne Camille La Flamme
Publikováno v:
Clinical & Translational Immunology, Vol 12, Iss 12, Pp n/a-n/a (2023)
Abstract Objectives Multiple sclerosis (MS) is a neurodegenerative disease characterised by inflammation and damage to myelin sheaths. While all current disease‐modifying treatments (DMTs) are very effective at reducing relapses, they do not slow t
Externí odkaz:
https://doaj.org/article/fbeca3f8b076416d96fc9ca8b16c2612
Autor:
Bronwyn M. Kivell, Shainnel O. Eans, Abdullah Allaoa, András Váradi, Lisa L. Wilson, Gavril W. Pasternak, Rajendra Uprety, Andrew C. Kruegel, John E. Pintar, Xiaohai Li, Samuel T. Slocum, Takeshi Irie, Jay P. McLaughlin, Brittany Scouller, Amy F. Alder, Michael D. Cameron, Sanjay Kalra, Ying-Xian Pan, Amanda Hunkele, Susruta Majumdar, Michael Ansonoff, Valerie Le Rouzic, Dalibor Sames, Soumen Chakraborty, Jin Xu
Publikováno v:
J Med Chem
The leaves of Mitragyna speciosa (kratom), a plant native to Southeast Asia, are increasingly used as a pain reliever and for attenuation of opioid withdrawal symptoms. Using the tools of natural products chemistry, chemical synthesis, and pharmacolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c5e470bfb54471841442c42450dcbe
https://doi.org/10.1021/acs.jmedchem.1c01111
https://doi.org/10.1021/acs.jmedchem.1c01111